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Journal of Natural Medicines

Erschienen in:

01.01.2016 | Original Paper

Purple potato (Solanum tuberosum L.) anthocyanins attenuate alcohol-induced hepatic injury by enhancing antioxidant defense

verfasst von: Zhihui Jiang, Chen Chen, Jian Wang, Wenyan Xie, Meng Wang, Xinsheng Li, Xiaoying Zhang

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2016

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Abstract

Alcoholic liver disease (ALD) is a serious and challenging health issue. In the past decade, natural components possessing hepatoprotective properties have gained more attention for ALD intervention. In this study, the phytochemical components of anthocyanins from purple potato were assessed using UPLC-MS/MS, and the hepatoprotective effects of purple potato anthocyanins (PPAs) were investigated in the ALD mouse model. Serum and liver biochemical parameters were determined, along with histopathological changes in liver tissue. In addition, the major contributors to alcohol-induced oxidative stress were assessed. The results indicated that the levels of aspartate transaminase and alanine transaminase were lower in the serum of the PPA-treated group than the alcohol-treated group. PPAs significantly inhibited the reduction of total cholesterol and triglycerides. Higher levels of superoxide dismutase and reduced glutathione enzymes as well as a reduction in the formation of malondialdehyde occurred in mice fed with PPAs. In addition, PPAs protected against increased alcohol-induced levels and activity of cytochrome P450 2E1 (CYP2E1), which demonstrates the effects of PPAs against alcohol-induced oxidative stress and liver injury. This study suggests that PPAs could be an effective therapeutic agent in alcohol-induced liver injuries by inhibiting CYP2E1 expression and thereby strengthening antioxidant defenses.

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Titel: Purple potato (Solanum tuberosum L.) anthocyanins attenuate alcohol-induced hepatic injury by enhancing antioxidant defense
verfasst von: Zhihui Jiang
Chen Chen
Jian Wang
Wenyan Xie
Meng Wang
Xinsheng Li
Xiaoying Zhang
Publikationsdatum: 01.01.2016
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2016
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-015-0935-3

Springer Medizin

Abstract

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