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01.01.2016 | Original Paper

What caused the changes in the usage of Atractylodis Macrocephalae Rhizoma from ancient to current times?

verfasst von: Xiaotong Wang, Linghui Li, Xiaoku Ran, Deqiang Dou, Bin Li, Bingyou Yang, Wei Li, Kazuo Koike, Haixue Kuang

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2016

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Abstract

Ancient Chinese medicine treatises on Atractylodis Macrocephalae Rhizoma (AMR), the rhizome of Atractylodes macrocephala Koidz, indicated that it possessed an expectorant effect. However, in modern times, it is commonly used as a tocolytic agent. In this study, the components of AMR that are responsible for its expectorant and tocolytic effects were evaluated in order to clarify the differences in its application between ancient and modern times. A decoction of AMR was separated into five fractions, namely, volatile oil (VO), petroleum ether (PE), alcohol eluate from macroporous resin (AE), water eluate from macroporous resin (WE), and polysaccharides (PS), using various separation methods. The expectorant experiment indicated that the VO fraction, which mainly contains atractylone, produced an obvious expectorant effect. The experiment that assessed the irritability of uterine smooth muscle (USM) showed that the PE, which is mainly composed of atractylenolides, and the PS, which is mainly composed of inulin-type polysaccharides, were the active fractions for tocolysis, but the VO fraction had the opposite action. These data suggested that volatile oils are the key components responsible for the usage change of AMR in both ancient and current usage.

Duan Q, Xu DJ, Liu CX, Li CL (2008) Research progress of Atractylodes macrocephala Koidz. Zhong Cao Yao 39: attached 4–6

Chen ZL (1989) Chemical constituents of Atractylodes macrocephala Koidz—Atractylentriol alpha methyl butyryl derivatives. Acta Chim Sinica 47:1022–1024

Liang Dynasty, Tao HJ, Shang ZJ compiled (1986) Ming Yi Bie Lu. People’s Medical Publishing House, Beijing, 22

An R, Liang MX (2010) Experimental research on the potential effect of Baizhu in antitussive, expectorant, analgesia, and hemostatic. J Tradit Chin Med 51:1125–1127

An R, Liang MX (2010) Literature investigation of atractylodes macrocephala’s lost and potential functional capacity. Chin J Tradit Chin Med Pharm 25:14–16

The Chinese Pharmacopoeia (2010) Medico-Pharmaceutical Science and Technology Publishing House, China, vol I, 95

Li LH, Ran XK, Xu YB, Li B, Dou DQ (2014) A method for evaluation of non-similarity degrees between splitting fractions of Atractylodis macrocephalae Rhizoma. Chin J Anal Chem 42:343–348CrossRef

Bai Q, Li M, Jia MR, Wang JK, Tang Y, Wu BZ (2004) Comparision of expectorant and antitussive actions between pinellia tubers from different areas of production. Chin Pharmaco Bull 20:1059–1062

Chen Q (1994) Experimental methodology of TCM pharmacology [M]. People’s Medical Publishing House, Beijing, pp 138–141

10.

Gong XJ, Wu ZX, Chen Z, Liu XD, Liu GQ (1995) Effects of Dipsacus asperoides on isolated uterus. J China Pharm Univ 26:115–118

11.

Guan H, Zhao HP, Tan Z, Wei YF (2011) Effect of leonurus and compound preparation on excised uterus smooth muscle of rats. J Inner Mongolia Agri Univ 3:25–28

12.

Xu SY, Bian RL, Chen X (1982) Methodology of pharmacological experiments [M]. People’s Medical Publishing House, Beijing, p 203

13.

Wang BC, Zhu LC, Chen Q (2005) Primary study on the application of serum pharmacology in Chinese traditional medicine. Colloids Surf B 43:194–197CrossRef

14.

Zhou HH, Zhao Lan X, Rui Qian Y (1993) Study on the Atractylodes macrocephala Koidz of uterine smooth muscle. J Anhui TCM C 12:39–40

15.

Lin Z, Liu YF, Qu Y, Li YS, Dou DQ, Kuang HX (2015) Characterisation of oligosaccharides from Baizhu by HILIC-MS. Nat Prod Res 29:1194–1200CrossRefPubMed

16.

Li LH, Dou DQ (2014) Study on stability of atractylon in volatile oil of Atractylodes macrocephala Koidz. World Sci Technol Mod TCM Mater Med 16:193–198

17.

Li CQ, He LC, Jin JQ (2007) Atractylenolide I and atractylenolide III inhibit lipopolysaccharide-induced TNF-α and NO production in macrophages. Phytother Res 21:347–353CrossRefPubMed

18.

Hwang JM, Tseng TH, Hsieh YS, Chou FP, Wang CJ, Chu CY (1996) Inhibitory effect of atractylon on tert-butyl hydroperoxide induced DNA damage and hepatic toxicity in rathepatocytes. Arch Toxicol 70:640–644CrossRefPubMed

19.

Zhu ZH (2005) Dan Xi Xin Fa. People’s Medical Publishing House, Beijing, 22

20.

Yin CH, Li LF, Jin YH, Yuan GD, Cao XF, Jiang YL (1999) Chin J Info Tradit Chin Med 6:35–37

21.

Zhang L (Qing dynasty). Zhao XQ correction (1996) Ben Jing Feng Yuan. China Medical Science Press, Beijing, pp 37–38

Titel: What caused the changes in the usage of Atractylodis Macrocephalae Rhizoma from ancient to current times?
verfasst von: Xiaotong Wang
Linghui Li
Xiaoku Ran
Deqiang Dou
Bin Li
Bingyou Yang
Wei Li
Kazuo Koike
Haixue Kuang
Publikationsdatum: 01.01.2016
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2016
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-015-0934-4

Springer Medizin

Abstract

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