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01.10.2011 | Original article

Quantification of myocardial perfusion SPECT using freeware package (cardioBull)

verfasst von: Koichi Okuda, Kenichi Nakajima, Tetsuo Hosoya, Takehiro Ishikawa, Shinro Matsuo, Masaya Kawano, Junichi Taki, Seigo Kinuya

Erschienen in: Annals of Nuclear Medicine | Ausgabe 8/2011

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Abstract

Objective

We have developed freeware package for automatically quantifying myocardial perfusion and ¹²³I-labeled radiopharmaceutical single-photon emission computed tomography (SPECT), which is called “cardioBull”. We aim to evaluate diagnostic performance of the detection of coronary artery disease (CAD) on the developed software in comparison with commercially available software package [Quantitative Perfusion SPECT (QPS)].

Methods

Stress-rest ^99mTc-sestamibi myocardial perfusion SPECT was performed in 36 patients with CAD and 35 control patients. A ≥75% stenosis in the coronary artery was identified by coronary angiography in the CAD group. Segmental perfusion defect score was automatically calculated by both cardioBull and QPS software. Summed stress score (SSS) was obtained to detect CAD by the receiver operator characteristic (ROC) analysis. Areas under the ROC curves (AUC) were calculated in patient-based and coronary-based analyses.

Results

Mean SSSs showed no significant difference between cardioBull and QPS (6.0 ± 7.1 vs. 5.6 ± 7.0). The AUC for cardioBull was equivalent to that for QPS (0.91 ± 0.04 vs. 0.87 ± 0.04, p = n.s.). Sensitivity, specificity, and accuracy for cardioBull were 89, 74, and 82%, respectively. For the regional detection of CAD, the AUC showed largest value in left anterior descending coronary artery (LAD) territory (0.86 ± 0.06 for cardioBull, 0.87 ± 0.06 for QPS, p = n.s.). Sensitivity, specificity and accuracy of cardioBull were 70, 88, and 83% for the LAD; 91, 62, and 66% for the left circumflex coronary artery (LCx); and 78, 69, and 70% for the right coronary artery (RCA), respectively.

Conclusions

The AUC, sensitivity, specificity and accuracy for the detection of CAD showed high diagnostic performance on the developed software. In addition, the developed software provided comparable diagnostic performance to the commercially available software package.

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Titel: Quantification of myocardial perfusion SPECT using freeware package (cardioBull)
verfasst von: Koichi Okuda
Kenichi Nakajima
Tetsuo Hosoya
Takehiro Ishikawa
Shinro Matsuo
Masaya Kawano
Junichi Taki
Seigo Kinuya
Publikationsdatum: 01.10.2011
Verlag: Springer Japan
Erschienen in: Annals of Nuclear Medicine / Ausgabe 8/2011
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-011-0504-0

Springer Medizin

Abstract

Objective

Methods

Results

Conclusions

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