Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Digestive Diseases and Sciences
Erschienen in: Digestive Diseases and Sciences 12/2010

01.12.2010 | Original Article

Quantification of the Effects of the Volume and Viscosity of Gastric Contents on Antral and Fundic Activity in the Rat Stomach Maintained Ex Vivo

Erschienen in: Digestive Diseases and Sciences | Ausgabe 12/2010

Einloggen, um Zugang zu erhalten

Abstract

Aims

The aim of this study was to examine the effect of varying the rheological properties of perfusate on the volume and muscular activity of the various compartments of the rat stomach.

Methods

Image analysis was used to quantify the activity of the ex vivo stomach preparations when perfused according to a ramp profile.

Results

The area of the fundus increased to a greater extent than that of the body when watery or viscous material was perfused. However, initial distension of the corpus was greater and occurred more rapidly when viscous material was perfused. Only the fundus expanded when perfusion followed the administration of verapamil. The frequency of antrocorporal contractions decreased significantly and the amplitude of antrocorporal contractions increased significantly with increase in gastric volume. The velocity of antrocorporal contractions did not vary with gastric volume but varied regionally in some preparations being faster distally than proximally. Neither the frequency, amplitude or velocity of antrocorporal contractions differed when pseudoplastic rather than watery fluid was perfused. However, the characteristics of antrocorporal contractions changed significantly when the stomach was perfused with material with rheological characteristics that induce different patterns of wall tension to those normally encountered. Hence, the mean frequency and speed of propagation of antrocorporal contractions increased and their direction of propagation became inconstant.
Literatur
1.
Schulze K. Imaging and modelling of digestion in the stomach and the duodenum. Neurogastroenterol Mot. 2006;18:172–183.CrossRef
2.
Blat S, Guerin S, Chauvin A, et al. Role of vagal innervation on intragastric distribution and emptying of liquid and semisolid meals in conscious pigs. Neurogastroenterol Mot. 2001;13:73–80.CrossRef
3.
Paterson CA, Anvari M, Tougas G, Huizinga JD. Determinants of occurrence and volume of transpyloric flow during gastric emptying of liquids in dogs. Dig Dis Sci. 2000;45:1509–1516.CrossRefPubMed
4.
Pal A, Indireshkumar K, Schwizer W, Abrahamsson B, Fried M, Brasseur JG. Gastric flow and mixing studied using computer simulation. Proc R Soc Lond B Biol Sci. 2004;271:2587–2594.CrossRef
5.
Hausken T, Mundt M, Samsom M. Low antroduodenal pressure gradients are responsible for gastric emptying of a low-caloric liquid meal in humans. Neurogastroenterol Mot. 2002;14:97–105.CrossRef
6.
Camilleri M, Malagelada JR, Brown ML, Becker G, Zinsmeister AR. Relation between antral motility and gastric emptying of solids and liquids in humans. Am J Physiol. 1985;249:G580–G585.PubMed
7.
Miller J, Kauffman G, Elashoff J, Ohashi H, Carter D, Meyer JH. Search for resistances controlling canine gastric emptying of liquid meals. Am J Physiol. 1981;241:G403–G415.PubMed
8.
Malbert CH, Mathis C. Antropyloric modulation of transpyloric flow of liquids in pigs. Gastroenterology. 1994;107:37–46.PubMed
9.
Indireshkumar K, Brasseur JG, Faas H, et al. Relative contributions of “pressure pump” and “peristaltic pump” to gastric emptying. Am J Physiol. 2000;278:G604–G616.
10.
Faas H, Hebbard GS, Feinle C, et al. Pressure-geometry relationship in the antroduodenal region in humans. Am J Physiol. 2001;281:G1214–G1220.
11.
Marciani L, Gowland PA, Fillery-Travis A, et al. Assessment of antral grinding of a model solid meal with echo-planar imaging. Am J Physiol. 2001;280:G844–G849.
12.
Kwiatek MA, Steingoetter A, Pal A, et al. Quantification of distal antral contractile motility in healthy human stomach with magnetic resonance imaging. J Magn Reson Imaging. 2006;24:1101–1109.CrossRefPubMed
13.
Malbert CH, Ruckebusch Y. Relationships between pressure and flow across the gastroduodenal junction in dogs. Am J Physiol. 1991;260:G653–G657.PubMed
14.
Wang XY, Lammers W, Bercik P, Huizinga JD. Lack of pyloric interstitial cells of Cajal explains distinct peristaltic motor patterns in stomach and small intestine. Am J Physiol. 2005;289:G539–G549.
15.
Maes BD, Hiele MI, Geypens BJ, Ghoos YF, Rutgeerts PJ. Gastric emptying of the liquid, solid and oil phase of a meal in normal volunteers and patients with Billroth ii gastrojejunostomy. Eur J Clin Invest. 1998;28:197–204.CrossRefPubMed
16.
Kunz P, Feinle-Bisset C, Faas H, et al. Effect of ingestion order of the fat component of a solid meal on intragastric fat distribution and gastric emptying assessed by MRI. J Magn Reson Imaging. 2005;21:383–390.CrossRefPubMed
17.
Meyer JH. The physiology of gastric motility and gastric emptying. In: Yamada T, ed. Textbook of gastroenterology, vol. 1. Philadelphia: JB Lippincott; 1991:137–157.
18.
Hinder RA, Kelly KA. Canine gastric emptying of solids and liquids. Am J Physiol. 1977;233:G335–G340.
19.
Marciani L, Gowland PA, Spiller RC, et al. Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI. Am J Physiol. 2001;280:G1227–G1233.
20.
Powley TL, Phillips RJ. Gastric satiation is volumetric, intestinal satiation is nutritive. Physiol Behav. 2004;82:69–74.CrossRefPubMed
21.
Sakaguchi T, Aono T, Ohtake M, Sandoh N. Interaction of glucose signals between the nucleus of the vagus nerve and the portal vein area in the regulation of gastric motility in rats. Brain Res Bull. 1994;33:469–471.CrossRefPubMed
22.
Lu Y, Owyang C. Secretin at physiological doses inhibits gastric motility via a vagal afferent pathway. Am J Physiol. 1995;268:G1012–G1016.PubMed
23.
Schirra J, Houck P, Wank U, Arnold R, Goke B, Katschinski M. Effects of glucagon-like peptide-1 (7–36) amide on antro-pyloro-duodenal motility in the interdigestive state and with duodenal lipid perfusion in humans. Gut. 2000;46:622–631.CrossRefPubMed
24.
Takahashi T, Owyang C. Mechanism of cholecystokinin-induced relaxation of the rat stomach. J Auton Nerv Syst. 1999;75:123–130.CrossRefPubMed
25.
McTigue DM, Rogers RC. Pancreatic polypeptide stimulates gastric motility through a vagal-dependent mechanism in rats. Neurosci Lett. 1995;188:93–96.CrossRefPubMed
26.
Lefebvre RA, Dick JMC, Guerin S, Malbert CH. Involvement of no in gastric emptying of semi-solid meal in conscious pigs. Neurogastroenterol Mot. 2005;17:229–235.CrossRef
27.
Mundt MW, Hausken T, Samsom M. Effect of intragastric barostat bag on proximal and distal gastric accommodation in response to liquid meal. Am J Physiol. 2002;283:G681–G686.
28.
Ropert A, des Varannes SB, Bizais Y, Rozé C, Galmiche JP. Simultaneous assessment of liquid emptying and proximal gastric tone in humans. Gastroenterology. 1993;105:667–674.PubMed
29.
Hennig GW, Costa M, Chen BN. Brookes SJH. Quantitative analysis of peristalsis in the guinea-pig small intestine using spatio-temporal maps. J Physiol. 1999;517.2:575–590.CrossRef
30.
Gregersen H. Biomechanics of the gastrointestinal tract: New perspectives in motility research and diagnostics. New York: Springer; 2003.
31.
Schulze-Delrieu K, Herman RJ, Shirazi SS, Brown BP. Contractions move contents by changing the configuration of the isolated cat stomach. Am J Physiol. 1998;274:G359–G369.PubMed
32.
Gärtner K. The forestomach of rats and mice, an effective device supporting digestive metabolism in muridae (review). J Exp Anim Sci. 2001;42:1–20.CrossRef
33.
Gärtner K, Pfaff J. The forestomach in rats and mice, a food store without bacterial protein digestion. Zentralbl Veterinarmed A. 1979;26:530–541.CrossRefPubMed
34.
Lentle RG, Janssen PWM, Asvarujanon P, Chambers P, Stafford KJ, Hemar Y. High definition mapping of circular and longitudinal motility in the terminal ileum of the brushtail possum trichosurus vulpecula with watery and viscous perfusates. J Comp Physiol. 2007;B177:543–556.
35.
Lentle RG, Janssen PWM. Physical characteristics of digesta and their influence on flow and mixing in the mammalian intestine: a review. J Comp Physiol. 2008;B178:673–690.
36.
Goh KKT, Matia-Merino L, Hall CE, Moughan PJ, Singh H. Complex rheological properties of a water-soluble extract from the fronds of the black tree fern, cyathea medullaris. Biomacromolecules. 2007;8:3414–3421.CrossRefPubMed
37.
Bird RB, Armstrong RC, Hassager O. Dynamics of polymeric liquids: fluid mechanics, 2nd edn. New York: Wiley; 1987.
38.
Berthoud HR, Hennig G, Campbell M, Volaufova J, Costa M. Video-based spatio-temporal maps for analysis of gastric motility in vitro: effects of vagal stimulation in guinea-pigs. Neurogastroenterol Mot. 2002;14:677–688.CrossRef
39.
Janssen PWM, Lentle RG, Hulls C, Ravindran V, Amerah AM. Spatiotemporal mapping of the motility of the isolated chicken caecum. J Comp Physiol. 2009;B179:593–604.
40.
Mandrek K, Golenhofen K. Phasic-rhythmical and tonic components in gastrointestinal motility. Prog Clin Biol Res. 1990;327:463–481.PubMed
41.
Zhao J, Liao D, Gregersen H. Tension and stress in the rat and rabbit stomach are location-and direction-dependent. Neurogastroenterol Mot. 2005;17:388–398.CrossRef
42.
Azpiroz F, Malagelada JR. Physiological variations in canine gastric tone measured by an electronic barostat. Am J Physiol. 1985;248:G229–G237.PubMed
43.
Blackshaw LA, Grundy D, Scratcherd T. Vagal afferent discharge from gastric mechanoreceptors during contraction and relaxation of the ferret corpus. J Auton Nerv Syst. 1987;18:19–24.CrossRefPubMed
44.
Wood JD. Physiology of the enteric nervous system. In: Johnson LR, ed. Physiology of the gastrointestinal tract. New York: Raven; 1994:423–482.
45.
Won KJ, Sanders KM, Ward SM. Interstitial cells of Cajal mediate mechanosensitive responses in the stomach. Proc Natl Acad Sci USA. 2005;102:14913–14918.CrossRefPubMed
46.
Gregersen H, Hausken T, Yang J, Odegaard S, Gilja OH. Mechanosensory properties in the human gastric antrum evaluated using B-mode ultrasonography during volume-controlled antral distension. Am J Physiol. 2006;290:G876–G882.
47.
48.
Liao D, Gregersen H, Hausken T, Gilja OH, Mundt M, Kassab G. Analysis of surface geometry of the human stomach using real-time 3-D ultrasonography in vivo. Neurogastroenterol Mot. 2004;16:315–324.CrossRef
49.
Distrutti E, Azpiroz F, Soldevilla A, Malagelada JR. Gastric wall tension determines perception of gastric distention. Gastroenterology. 1999;116:1035–1042.CrossRefPubMed
50.
Hirst GDS, Beckett EAH, Sanders KM, Ward SM. Regional variation in contribution of myenteric and intramuscular interstitial cells of Cajal to generation of slow waves in mouse gastric antrum. J Physiol. 2002;540:1003–1012.CrossRefPubMed
51.
Hennig GW, Brookes SJH, Costa M. Excitatory and inhibitory motor reflexes in the isolated guinea-pig stomach. J Physiol. 1997;501:197–212.CrossRefPubMed
52.
Lammers W, Ver Donck L, Stephen B, Smets D, Schuurkes JAJ. Origin and propagation of the slow wave in the canine stomach: the outlines of a gastric conduction system. Am J Physiol. 2009;296:G1200–G1210.
53.
Hashitani H, Garcia-Londoño AP, Hirst GDS, Edwards FR. Atypical slow waves generated in gastric corpus provide dominant pacemaker activity in guinea pig stomach. J Physiol. 2005;569:459–465.CrossRefPubMed
54.
Lin HC, Zhao XT, Chung B, Gu YG, Elashoff JD. Frequency of gastric pacesetter potential depends on volume and site of distension. Am J Physiol. 1996;270:G470–G475.PubMed
55.
Gregersen H, Kassab G. Biomechanics of the gastrointestinal tract. Neurogastroenterol Mot. 1996;8:277–297.
56.
Novitol R, Coffin B, Azpiroz F, Mearin F, Serra J, Malagelada JR. Gastric tone determines the sensitivity of the stomach to distension. Gastroenterology. 1995;108:330–336.CrossRef
57.
Ahmed AB, Gilja OH, Hausken T, Gregersen H, Matre K. Strain measurement during antral contractions by ultrasound strain rate imaging: influence of erythromycin. Neurogastroenterol Mot. 2009;21:170–179.CrossRef
58.
Andrews PL, Grundy D, Scratcherd T. Reflex excitation of antral motility induced by gastric distension in the ferret. J Physiol. 1980;298:79–84.PubMed
59.
Urbain JL, Van Cutsem E, Siegel JA, et al. Visualization and characterization of gastric contractions using a radionuclide technique. Am J Physiol. 1990;259:G1062–G1067.PubMed
60.
Carlson HC, Code CF, Nelson RA. Motor action of the canine gastroduodenal junction: a cineradiographic, pressure, and electric study. Dig Dis Sci. 1966;11:155–172.CrossRef
61.
Keinke O, Ehrlein HJ. Effect of oleic acid on canine gastroduodenal motility, pyloric diameter and gastric emptying. Q J Exp Physiol. 1983;68:675–686.PubMed
62.
Prove J, Ehrlein HJ. Motor function of gastric antrum and pylorus for evacuation of low and high viscosity meals in dogs. Gut. 1982;23:150–156.CrossRefPubMed
63.
Russell J, Bass P. Canine gastric emptying of fiber meals: Influence of meal viscosity and antroduodenal motility. Am J Physiol. 1985;249:G662–G667.PubMed
64.
Hennig GW, Hirst GDS, Park KJ, et al. Propagation of pacemaker activity in the guinea-pig antrum. J Physiol. 2004;556:585–599.CrossRefPubMed
65.
Gao C, Arendt-Nielsen L, Liu W, Petersen P, Drewes AM, Gregersen H. Sensory and biomechanical responses to ramp-controlled distension of the human duodenum. Am J Physiol. 2003;284:G461–G471.
66.
Barlow JD, Gregersen H, Thompson DG. Identification of the biomechanical factors associated with the perception of distension in the human esophagus. Am J Physiol. 2002;282:G683–G689.
67.
Yuan SY, Costa M, Brookes SJH. Neuronal control of the pyloric sphincter of the guinea-pig. Neurogastroenterol Mot. 2001;13:187–198.CrossRef
68.
Mroz CT, Kelly KA. The role of the extrinsic antral nerves in the regulation of gastric emptying. Surg Gynecol Obstet. 1977;145:369–377.PubMed
69.
Allescher HD, Daniel EE, Dent J, Fox JE, Kostolanska F. Extrinsic and intrinsic neural control of pyloric sphincter pressure in the dog. J Physiol. 1988;401:17–38.PubMed
70.
Cannon WB. The movements of the stomach studied by means of the röntgen rays. Am J Physiol. 1898;1:359–382.
71.
Huizinga JD, Lammers WJEP. Gut peristalsis is governed by a multitude of cooperating mechanisms. Am J Physiol. 2009;296:G1–G8.
Metadaten
Titel
Quantification of the Effects of the Volume and Viscosity of Gastric Contents on Antral and Fundic Activity in the Rat Stomach Maintained Ex Vivo
Publikationsdatum
01.12.2010
Erschienen in
Digestive Diseases and Sciences / Ausgabe 12/2010
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-010-1164-y

Weitere Artikel der Ausgabe 12/2010

Digestive Diseases and Sciences 12/2010 Zur Ausgabe

Correspondence

Metal Stents and Biliary Obstruction Secondary to Lymphoma: A Tale of Caution

Original Article

Recurrent Acute Pancreatitis: Clinical Profile and an Approach to Diagnosis

Original Article

Germline Mutation Analysis of STK11 Gene Using Direct Sequencing and Multiplex Ligation-Dependent Probe Amplification Assay in Korean Children with Peutz-Jeghers Syndrome

Review

Occult Hepatitis B: Clinical Implications and Treatment Decisions

Original Article

The Impact of Advances in Instrumentation and Techniques of Colonoscopy from 1988 to 2008 on Inpatient Colonoscopy Performance at a High Volume Endoscopy Unit in the United States: Significantly Shorter Procedure Time, Higher Completion Rate, Performance on Sicker Inpatients, and Near Disappearance of Flexible Sigmoidoscopy

Correspondence

A New Second-Line Sequential Regimen for Helicobacter pylori Eradication Based on Levofloxacin: A Pilot Study

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise