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Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 9/2021

18.05.2021 | Inflammatory Disorders

Quantitative evaluation of lipid layer thickness and blinking in children with allergic conjunctivitis

verfasst von: Boyu Yang, Kuiyao Wen, Jing Li, Shiyao Zhang, Zixin Fan, Xiaoling Liang, Lingyi Liang

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 9/2021

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Abstract

Purpose

To quantitatively evaluate the lipid layer thickness (LLT) and blinking in children with or without allergic conjunctivitis (AC), and to compare those between the different types of AC.

Methods

For this case–control study, 81 children with symptomatic AC with an average age of 9.62 ± 2.67 years were enrolled and subdivided according to the subtypes of AC, including seasonal/perennial allergic conjunctivitis group and vernal keratoconjunctivitis (VKC)/atopic keratoconjunctivitis (AKC) group. Another 82 age-matched healthy children were enrolled as control group. All subjects underwent routine eye examination and measurements of LLT, the number of incomplete or total blinking, partial blinking rate by the LipiView interferometer over a 10-s period. Other ocular surface assessment included fluorescein tear breakup time (TBUT), lower tear meniscus height, meibomian gland loss (MGL), meibum expressibility and quality.

Results

Pediatric patients with AC had significant thinner LLT, shorter TBUT, decreased total blinking but increased partial blinking rate, especially in those with VKC/AKC (all P < 0.05). A significant deterioration of meibomian gland parameters was observed in AC group when compared with control subjects, demonstrated by severe upper and lower MGL, lid margin abnormalities, decreased meibum expressibility, and abnormal meibum quality, all of which were worse in the severe type of AC (all P < 0.05). Thinner LLT was significantly correlated with decreased TBUT (β = 3.666, P < 0.001) and severity of upper MGL (β =  − 7.701, P = 0.002).

Conclusion

Decreased LLT and blinking disorders in pediatric patients with AC may contribute to lipid layer deficiency in the long run, which should be considered and appropriately diagnosed for a more precise treatment.
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Metadaten
Titel
Quantitative evaluation of lipid layer thickness and blinking in children with allergic conjunctivitis
verfasst von
Boyu Yang
Kuiyao Wen
Jing Li
Shiyao Zhang
Zixin Fan
Xiaoling Liang
Lingyi Liang
Publikationsdatum
18.05.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 9/2021
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-021-05199-9

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