Skip to main content
Erschienen in: Abdominal Radiology 9/2022

23.07.2021 | Special Section: Quantitative Imaging

Quantitative imaging of uterine cancers with diffusion-weighted MRI and 18-fluorodeoxyglucose PET/CT

verfasst von: Madeleine Sertic, Aoife Kilcoyne, Onofrio Antonio Catalano, Susanna I. Lee

Erschienen in: Abdominal Radiology | Ausgabe 9/2022

Einloggen, um Zugang zu erhalten

Abstract

Imaging plays an important role in the diagnosis and treatment of women with uterine cervical and endometrial cancers. Quantitative imaging, through MRI, PET/CT, and hybrid PET/MRI, allows for characterization of primary tumors beyond anatomic and qualitative descriptors. MRI diffusion-weighted imaging (DWI) yields an apparent diffusion coefficient (ADC), which can be applied in both the pre-and post-treatment assessment of uterine tumors. PET/CT assesses metabolic activity, and measurement of tumor standardized uptake value (SUV) is a useful metric in the staging of uterine malignancies. Hybrid PET/MRI is an emerging modality that combines the soft tissue contrast of MRI with the molecular imaging capability of PET. This review provides an overview of these quantitative imaging modalities, and their current and potential roles in the assessment of uterine cervical and cancer.
Literatur
12.
15.
Zurück zum Zitat Mitchell DG, Snyder B, Coakley F, Reinhold C, Thomas G, Amendola M, et al. Early invasive cervical cancer: tumor delineation by magnetic resonance imaging, computed tomography, and clinical examination, verified by pathologic results, in the ACRIN 6651/GOG 183 Intergroup Study. J Clin Oncol. 2006;24(36):5687-94. https://doi.org/10.1200/jco.2006.07.4799.CrossRefPubMed Mitchell DG, Snyder B, Coakley F, Reinhold C, Thomas G, Amendola M, et al. Early invasive cervical cancer: tumor delineation by magnetic resonance imaging, computed tomography, and clinical examination, verified by pathologic results, in the ACRIN 6651/GOG 183 Intergroup Study. J Clin Oncol. 2006;24(36):5687-94. https://​doi.​org/​10.​1200/​jco.​2006.​07.​4799.CrossRefPubMed
24.
Zurück zum Zitat Thomeer MG, Vandecaveye V, Braun L, Mayer F, Franckena-Schouten M, de Boer P, et al. Evaluation of T2-W MR imaging and diffusion-weighted imaging for the early post-treatment local response assessment of patients treated conservatively for cervical cancer: a multicentre study. European radiology. 2019;29(1):309-18. https://doi.org/10.1007/s00330-018-5510-3.CrossRefPubMed Thomeer MG, Vandecaveye V, Braun L, Mayer F, Franckena-Schouten M, de Boer P, et al. Evaluation of T2-W MR imaging and diffusion-weighted imaging for the early post-treatment local response assessment of patients treated conservatively for cervical cancer: a multicentre study. European radiology. 2019;29(1):309-18. https://​doi.​org/​10.​1007/​s00330-018-5510-3.CrossRefPubMed
26.
Zurück zum Zitat Moharamzad Y, Davarpanah AH, Yaghobi Joybari A, Shahbazi F, Esmaeilian Toosi L, Kooshkiforooshani M, et al. Diagnostic performance of apparent diffusion coefficient (ADC) for differentiating endometrial carcinoma from benign lesions: a systematic review and meta-analysis. Abdom Radiol (NY). 2021;46(3):1115-28. https://doi.org/10.1007/s00261-020-02734-w.CrossRefPubMed Moharamzad Y, Davarpanah AH, Yaghobi Joybari A, Shahbazi F, Esmaeilian Toosi L, Kooshkiforooshani M, et al. Diagnostic performance of apparent diffusion coefficient (ADC) for differentiating endometrial carcinoma from benign lesions: a systematic review and meta-analysis. Abdom Radiol (NY). 2021;46(3):1115-28. https://​doi.​org/​10.​1007/​s00261-020-02734-w.CrossRefPubMed
27.
Zurück zum Zitat Shih IL, Yen RF, Chen CA, Chen BB, Wei SY, Chang WC, et al. Standardized uptake value and apparent diffusion coefficient of endometrial cancer evaluated with integrated whole-body PET/MR: Correlation with pathological prognostic factors. J Magn Reson Imaging. 2015;42(6):1723-32. https://doi.org/10.1002/jmri.24932.CrossRefPubMed Shih IL, Yen RF, Chen CA, Chen BB, Wei SY, Chang WC, et al. Standardized uptake value and apparent diffusion coefficient of endometrial cancer evaluated with integrated whole-body PET/MR: Correlation with pathological prognostic factors. J Magn Reson Imaging. 2015;42(6):1723-32. https://​doi.​org/​10.​1002/​jmri.​24932.CrossRefPubMed
29.
Zurück zum Zitat Reyes-Pérez JA, Villaseñor-Navarro Y, Jiménez de Los Santos ME, Pacheco-Bravo I, Calle-Loja M, Sollozo-Dupont I. The apparent diffusion coefficient (ADC) on 3-T MRI differentiates myometrial invasion depth and histological grade in patients with endometrial cancer. Acta Radiol. 2020;61(9):1277-86. https://doi.org/10.1177/0284185119898658.CrossRefPubMed Reyes-Pérez JA, Villaseñor-Navarro Y, Jiménez de Los Santos ME, Pacheco-Bravo I, Calle-Loja M, Sollozo-Dupont I. The apparent diffusion coefficient (ADC) on 3-T MRI differentiates myometrial invasion depth and histological grade in patients with endometrial cancer. Acta Radiol. 2020;61(9):1277-86. https://​doi.​org/​10.​1177/​0284185119898658​.CrossRefPubMed
30.
Zurück zum Zitat Rechichi G, Galimberti S, Signorelli M, Franzesi CT, Perego P, Valsecchi MG, et al. Endometrial cancer: correlation of apparent diffusion coefficient with tumor grade, depth of myometrial invasion, and presence of lymph node metastases. AJR Am J Roentgenol. 2011;197(1):256-62. https://doi.org/10.2214/ajr.10.5584.CrossRefPubMed Rechichi G, Galimberti S, Signorelli M, Franzesi CT, Perego P, Valsecchi MG, et al. Endometrial cancer: correlation of apparent diffusion coefficient with tumor grade, depth of myometrial invasion, and presence of lymph node metastases. AJR Am J Roentgenol. 2011;197(1):256-62. https://​doi.​org/​10.​2214/​ajr.​10.​5584.CrossRefPubMed
34.
Zurück zum Zitat Nogami Y, Iida M, Banno K, Kisu I, Adachi M, Nakamura K, et al. Application of FDG-PET in cervical cancer and endometrial cancer: utility and future prospects. Anticancer Res. 2014;34(2):585-92.PubMed Nogami Y, Iida M, Banno K, Kisu I, Adachi M, Nakamura K, et al. Application of FDG-PET in cervical cancer and endometrial cancer: utility and future prospects. Anticancer Res. 2014;34(2):585-92.PubMed
39.
Zurück zum Zitat Benz MR, Evilevitch V, Allen-Auerbach MS, Eilber FC, Phelps ME, Czernin J, et al. Treatment monitoring by 18F-FDG PET/CT in patients with sarcomas: interobserver variability of quantitative parameters in treatment-induced changes in histopathologically responding and nonresponding tumors. J Nucl Med. 2008;49(7):1038-46. https://doi.org/10.2967/jnumed.107.050187.CrossRefPubMed Benz MR, Evilevitch V, Allen-Auerbach MS, Eilber FC, Phelps ME, Czernin J, et al. Treatment monitoring by 18F-FDG PET/CT in patients with sarcomas: interobserver variability of quantitative parameters in treatment-induced changes in histopathologically responding and nonresponding tumors. J Nucl Med. 2008;49(7):1038-46. https://​doi.​org/​10.​2967/​jnumed.​107.​050187.CrossRefPubMed
40.
Zurück zum Zitat Shankar LK, Hoffman JM, Bacharach S, Graham MM, Karp J, Lammertsma AA, et al. Consensus recommendations for the use of 18F-FDG PET as an indicator of therapeutic response in patients in National Cancer Institute Trials. J Nucl Med. 2006;47(6):1059-66.PubMed Shankar LK, Hoffman JM, Bacharach S, Graham MM, Karp J, Lammertsma AA, et al. Consensus recommendations for the use of 18F-FDG PET as an indicator of therapeutic response in patients in National Cancer Institute Trials. J Nucl Med. 2006;47(6):1059-66.PubMed
51.
Zurück zum Zitat St Laurent JD, Davis MR, Feltmate CM, Goodman A, Del Carmen MG, Horowitz NE, et al. Prognostic Value of Preoperative Imaging: Comparing 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography to Computed Tomography Alone for Preoperative Planning in High-risk Histology Endometrial Carcinoma. Am J Clin Oncol. 2020;43(10):714-9. https://doi.org/10.1097/coc.0000000000000735.CrossRefPubMed St Laurent JD, Davis MR, Feltmate CM, Goodman A, Del Carmen MG, Horowitz NE, et al. Prognostic Value of Preoperative Imaging: Comparing 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography to Computed Tomography Alone for Preoperative Planning in High-risk Histology Endometrial Carcinoma. Am J Clin Oncol. 2020;43(10):714-9. https://​doi.​org/​10.​1097/​coc.​0000000000000735​.CrossRefPubMed
58.
Zurück zum Zitat Grueneisen J, Beiderwellen K, Heusch P, Gratz M, Schulze-Hagen A, Heubner M, et al. Simultaneous positron emission tomography/magnetic resonance imaging for whole-body staging in patients with recurrent gynecological malignancies of the pelvis: a comparison to whole-body magnetic resonance imaging alone. Invest Radiol. 2014;49(12):808-15. https://doi.org/10.1097/rli.0000000000000086.CrossRefPubMed Grueneisen J, Beiderwellen K, Heusch P, Gratz M, Schulze-Hagen A, Heubner M, et al. Simultaneous positron emission tomography/magnetic resonance imaging for whole-body staging in patients with recurrent gynecological malignancies of the pelvis: a comparison to whole-body magnetic resonance imaging alone. Invest Radiol. 2014;49(12):808-15. https://​doi.​org/​10.​1097/​rli.​0000000000000086​.CrossRefPubMed
64.
Metadaten
Titel
Quantitative imaging of uterine cancers with diffusion-weighted MRI and 18-fluorodeoxyglucose PET/CT
verfasst von
Madeleine Sertic
Aoife Kilcoyne
Onofrio Antonio Catalano
Susanna I. Lee
Publikationsdatum
23.07.2021
Verlag
Springer US
Erschienen in
Abdominal Radiology / Ausgabe 9/2022
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-021-03218-1

Weitere Artikel der Ausgabe 9/2022

Abdominal Radiology 9/2022 Zur Ausgabe

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Klinik aktuell Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

IT für Ärzte Nachrichten

Darauf haben viele Praxen gewartet: Das Zi hat eine Liste von Praxisverwaltungssystemen veröffentlicht, die von Nutzern positiv bewertet werden. Eine gute Grundlage für wechselwillige Ärztinnen und Psychotherapeuten.

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.