Erschienen in:
05.01.2018 | Original Paper
Quantitative inversion time prescription for myocardial late gadolinium enhancement using T1-mapping-based synthetic inversion recovery imaging: reducing subjectivity in the estimation of inversion time
verfasst von:
Sebastian Gassenmaier, Rob J. van der Geest, U. Joseph Schoepf, Pal Suranyi, Wolfgang G. Rehwald, Carlo N. De Cecco, Domenico Mastrodicasa, Moritz H. Albrecht, Domenico De Santis, Virginia W. Lesslie, Balazs Ruzsics, Akos Varga-Szemes
Erschienen in:
The International Journal of Cardiovascular Imaging
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Ausgabe 6/2018
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Abstract
To develop a quantitative T1-mapping-based synthetic inversion recovery (IRsynth) approach to calculate the optimal inversion time (TI0) for late gadolinium enhancement (LGE) imaging. Prospectively enrolled patients (n = 130, 58 ± 16 years) underwent cardiac MRI on a 1.5T system including Look-Locker TI-scout (LL), modified LL IR (MOLLI)-based T1-mapping, and LGE acquisitions. Patients were randomized into two groups: LL group (TI-scout followed T1-mapping) or MOLLI group (T1-mapping followed TI-scout). In both groups, the second acquisition was used to determine the TI0 for LGE. IRsynth images were generated from T1-maps between TI = 200–400 ms in 5 ms increments. Image quality was rated on a 3-point scale and the remote/background signal intensity ratio (SIR) was calculated. In the LL group (n = 53), the TI-scout-based TI0 was significantly shorter compared to IRsynth [230 ms (219–242) vs. 280 ms (263–297), P < 0.0001]. The TI0 used for LGE was set 30–40 ms longer [261 ms (247–276), P < 0.0001] than the TI-scout-based TI0, resulting in a TI0 ~ 20 ms shorter than what was obtained by IRsynth (P = 0.0156). In the MOLLI group (n = 63), IRsynth-based TI0 was significantly longer than the TI-scout-based TI0 [298 ms (262–334) vs. 242 ms (217–267), P = 0.0313]. The quality of myocardial nulling was rated higher [2.4 (2.2–2.5) vs. 2.0 (1.8–2.1), P = 0.0042] and the remote/background SIR was found to be more optimal (1.6 [1.1–2.1] vs. 2.6 [1.8–3.3], P = 0.0256) in the MOLLI group. T1-based IRsynth selects TI0 for LGE more accurately than conventional TI-scout imaging. IRsynth improves TI0 selection by providing excellent visualization of the representative image contrast for LGE images, reducing operator dependence in LGE acquisition.