Background
Methods
Source population
Melanoma in situ | Superficial spreading melanoma | Nodular melanoma | |||||||||||||
NHW (n = 87852) | HW (n = 1890) | Black (n = 222) | Asian/PI (n = 180) |
P
| NHW (n = 84790) | HW (n = 1993) | Black (n = 218) | Asian/PI (n = 364) |
P
| NHW (n = 19260) | HW (n = 689) | Black (n = 106) | Asian/PI (n = 160) |
P
| |
Gender | <0.001 | <0.001 | <0.001 | ||||||||||||
Male | 54.7 | 36.0 | 45.0 | 44.6 | 53.3 | 35.6 | 42.2 | 49.2 | 61.6 | 51.8 | 44.3 | 56.3 | |||
Female | 45.3 | 64.0 | 55.0 | 55.4 | 46.7 | 64.4 | 57.8 | 50.8 | 38.4 | 48.2 | 55.7 | 43.8 | |||
Marital Status | <0.001 | <0.001 | <0.001 | ||||||||||||
Single | 12.6 | 15.4 | 22.1 | 18.8 | 15.4 | 18.8 | 26.3 | 23.9 | 14.9 | 21.3 | 37.0 | 17.6 | |||
Married | 73.9 | 70.8 | 54.7 | 67.7 | 71.2 | 67.7 | 48.1 | 62.7 | 63.5 | 58.5 | 34.8 | 62.0 | |||
Separated/divorced/widowed | 13.5 | 13.8 | 23.3 | 13.5 | 13.4 | 13.5 | 25.6 | 13.4 | 21.6 | 20.2 | 28.3 | 20.4 | |||
Age at diagnosis | 60.5 ± 15.9 | 55.6 ± 16.9 | 59.2 ± 16.2 | 55.0 ± 17.9 | <0.001 | 54.7 ± 16.7 | 49.2 ± 16.5 | 56.0 ± 17.7 | 52.7 ± 17.3 | <0.001 | 62.1 ± 17.7 | 55.9 ± 19.1 | 62.7 ± 18.1 | 60.3 ± 20.1 | <0.001 |
Anatomic Site | <0.001 | <0.001 | <0.001 | ||||||||||||
Face/head/neck | 25.7 | 28.6 | 18.0 | 22.3 | 13.7 | 14.4 | 9.6 | 11.0 | 22.9 | 22.5 | 15.1 | 16.9 | |||
Trunk | 30.9 | 24.1 | 12.6 | 26.0 | 39.0 | 33.9 | 29.8 | 36.0 | 32.1 | 28.3 | 18.9 | 26.3 | |||
Upper Extremity | 25.9 | 23.9 | 24.8 | 22.8 | 25.7 | 22.9 | 17.0 | 18.7 | 27.1 | 20.8 | 12.3 | 13.8 | |||
Lower Extremity | 17.0 | 23.0 | 44.1 | 29.0 | 21.0 | 28.4 | 42.2 | 33.5 | 17.4 | 28.0 | 51.9 | 43.1 | |||
Other | 0.6 | 0.5 | 0.5 | 0 | 0.5 | 0.4 | 1.4 | 0.8 | 0.6 | 0.4 | 1.9 | 0 | |||
Thickness of tumor (mm) | 0.80 ± 1.83 | 0.78 ± 1.85 | 1.02 ± 1.31 | 0.68 ± 0.88 | 0.980 | 0.92 ± 1.09 | 1.01 ± 1.20 | 1.51 ± 2.11 | 1.36 ± 1.96 | <0.001 | 3.27 ± 2.51 | 3.93 ± 3.02 | 4.22 ± 3.18 | 4.23 ± 3.04 | <0.001 |
Satellite nodules | 0.012 | 0.280 | |||||||||||||
No | - | - | - | - | 97.0 | 97.2 | 95.9 | 95.3 | 93.5 | 93.9 | 88.7 | 95.6 | |||
Yes | - | - | - | - | 0.6 | 1.1 | 0.9 | 0.8 | 3.6 | 3.5 | 4.7 | 3.1 | |||
Unknown | - | - | - | - | 2.4 | 1.7 | 3.2 | 3.8 | 3.0 | 2.6 | 6.6 | 1.3 | |||
Ulceration | 0.242 | 0.001 | 0.001 | ||||||||||||
No | 92.2 | 91.7 | 94.1 | 91.1 | 86.7 | 87.6 | 83.5 | 87.4 | 59.8 | 56.0 | 50.9 | 56.3 | |||
Yes | 0.5 | 0.4 | 0.9 | 0 | 4.9 | 6.0 | 8.3 | 6.6 | 31.4 | 38.3 | 37.7 | 35.6 | |||
Unknown | 7.3 | 7.9 | 5.0 | 8.9 | 8.4 | 6.4 | 8.3 | 6.0 | 8.8 | 5.7 | 11.3 | 8.1 | |||
Lymph node extension | 0.866 | <0.001 | <0.001 | ||||||||||||
None | 99.9 | 99.8 | 99.5 | 100.0 | 72.7 | 78.8 | 67.0 | 76.9 | 63.3 | 60.4 | 52.8 | 58.1 | |||
Regional | 0 | 0 | 0 | 0 | 3.2 | 4.7 | 5.0 | 6.6 | 16.6 | 25.3 | 18.9 | 25.0 | |||
Distant | 0 | 0 | 0 | 0 | 0.1 | 0.2 | 0 | 0 | 0.9 | 2.0 | 5.7 | 1.9 | |||
Unknown | 0.1 | 0.2 | 0.5 | 0 | 24.0 | 16.3 | 28.0 | 16.5 | 19.2 | 12.3 | 22.6 | 15.0 | |||
Stage | 0.996 | <0.001 | <0.001 | ||||||||||||
In situ | 100.0 | 100.0 | 100.0 | 100.0 | - | - | - | - | - | - | - | - | |||
Localized | - | - | - | - | 92.7 | 90.8 | 86.7 | 87.9 | 62.1 | 51.1 | 43.4 | 52.5 | |||
Regional | - | - | - | - | 5.4 | 7.4 | 9.6 | 9.6 | 32.0 | 40.1 | 38.7 | 41.3 | |||
Distant | - | - | - | - | 0.4 | 0.8 | 0.9 | 0.8 | 4.1 | 7.1 | 14.2 | 5.6 | |||
Unstaged | 0.0 | - | - | - | 1.5 | 1.1 | 2.8 | 1.6 | 1.9 | 1.7 | 3.8 | 0.6 | |||
Treatment | 0.152 | 0.005 | 0.033 | ||||||||||||
No treatment | 4.1 | 5.8 | 5.0 | 4.2 | 1.6 | 2.0 | 1.4 | 2.2 | 1.5 | 1.6 | 1.9 | 1.3 | |||
Surgery | 95.1 | 93.7 | 94.6 | 95.3 | 97.1 | 97.1 | 95.4 | 95.6 | 94.7 | 94.8 | 90.6 | 93.8 | |||
Radiation | 0.1 | 0.1 | 0 | 0.2 | 0.1 | 0 | 0.5 | 0 | 0.2 | 0 | 0 | 1.3 | |||
Radiation & Surgery | 0.4 | 0.3 | 0 | 0 | 0.9 | 0.8 | 1.4 | 1.9 | 3.3 | 3.2 | 5.7 | 3.1 | |||
Unknown | 0.2 | 0.2 | 0.5 | 0.2 | 0.4 | 0.1 | 1.4 | 0.3 | 0.4 | 0.4 | 1.9 | 0.6 | |||
Type of surgery | <0.001 | <0.001 | <0.001 | ||||||||||||
No surgery | 4.2 | 5.9 | 5.1 | 4.5 | 1.7 | 2.1 | 1.6 | 2.3 | 1.8 | 1.7 | 2.0 | 2.1 | |||
Biopsy | 65.8 | 63.9 | 51.6 | 55.8 | 43.0 | 43.6 | 37.0 | 42.9 | 32.5 | 35.1 | 34.3 | 32.9 | |||
Wide excision | 29.8 | 29.9 | 40.0 | 39.3 | 55.0 | 53.5 | 59.3 | 54.2 | 64.3 | 57.3 | 57.6 | 60.3 | |||
Amputation | 0.1 | 0.2 | 2.8 | 0.5 | 0.1 | 0.4 | 2.1 | 0.3 | 0.5 | 3.5 | 3.0 | 4.1 | |||
Surgery NOS | 0.1 | 0.1 | 0.5 | 0 | 0.3 | 0.5 | 0 | 0.3 | 0.9 | 2.4 | 3.0 | 0.7 | |||
Survival time (month) | 300.7 ± 3.0 | 355.9 ± 13.1 | 287.8 ± 15.3 | 325.6 ± 19.6 | <0.001 | 298.7 ± 1.2 | 305.8 ± 6.3 | 277.1 ± 17.5 | 300.2 ± 13.6 | 0.001 | 168.5 ± 1.8 | 160.3 ± 9.6 | 106.9 ± 14.3 | 145.8 ± 16.6 | 0.033 |
Lentigo maligna melanoma | Acral lentiginous melanoma, malignant | Malignant melanoma, NOS | |||||||||||||
NHW (n = 17226) | HW (n = 250) | Black (n = 46) | Asian/PI (n = 69) |
P
| NHW (n = 1822) | HW (n = 300) | Black (n = 215) | Asian/PI (n = 168) |
P
| NHW (n = 127924) | HW (n = 3807) | Black (n = 788) | Asian/PI (n = 861) |
P
| |
Gender | <0.001 | 0.138 | <0.001 | ||||||||||||
Male | 67.2 | 54.4 | 54.3 | 56.5 | 46.5 | 46.3 | 40.9 | 53.0 | 57.5 | 42.6 | 48.4 | 48.5 | |||
Female | 32.8 | 45.6 | 45.7 | 43.5 | 53.5 | 53.7 | 59.1 | 47.0 | 42.5 | 57.4 | 51.6 | 51.5 | |||
Marital Status | 0.283 | <0.001 | <0.001 | ||||||||||||
Single | 8.3 | 11.6 | 6.3 | 7.4 | 12.9 | 15.2 | 17.3 | 10.2 | 14.8 | 20.5 | 28.0 | 16.2 | |||
Married | 71.4 | 71.1 | 59.4 | 74.1 | 65.7 | 59.8 | 42.6 | 67.5 | 68.8 | 63.1 | 42.3 | 66.8 | |||
Separated/divorced/widowed | 20.3 | 17.4 | 34.4 | 18.5 | 21.5 | 25.0 | 40.1 | 22.3 | 16.4 | 16.3 | 29.7 | 17.0 | |||
Age at diagnosis | 69.7 ± 12.6 | 68.0 ± 14.5 | 65.3 ± 13.2 | 66.3 ± 16.8 | 0.001 | 63.6 ± 16.3 | 61.4 ± 16.8 | 65.5 ± 16.4 | 64.1 ± 16.1 | 0.034 | 58.9 ± 17.2 | 53.5 ± 18.2 | 60.3 ± 18.5 | 57.0 ± 19.3 | <0.001 |
Anatomic Site | <0.001 | 0.010 | <0.001 | ||||||||||||
Face/head/neck | 60.3 | 70.4 | 37.0 | 46.4 | 1.8 | 1.3 | 0.5 | 0 | 18.6 | 17.5 | 9.9 | 10.6 | |||
Trunk | 15.3 | 11.6 | 8.7 | 15.9 | 2.2 | 1.0 | 0 | 0 | 32.2 | 24.4 | 15.4 | 20.0 | |||
Upper Extremity | 19.3 | 11.6 | 6.5 | 14.5 | 20.2 | 16.3 | 15.3 | 19.0 | 23.7 | 19.7 | 11.3 | 17.5 | |||
Lower Extremity | 4.4 | 6.0 | 45.7 | 23.2 | 75.6 | 81.0 | 83.7 | 79.8 | 17.5 | 26.6 | 43.8 | 33.6 | |||
Other | 0.6 | 0.4 | 2.2 | 0 | 0.2 | 0.3 | 0.5 | 1.2 | 8.0 | 11.7 | 19.7 | 18.4 | |||
Thickness of tumor (mm) | 0.70 ± 1.00 | 0.73 ± 0.85 | 1.98 ± 2.59 | 0.96 ± 1.31 | <0.001 | 2.12 ± 2.08 | 2.38 ± 2.27 | 2.53 ± 2.39 | 2.99 ± 2.47 | <0.001 | 1.10 ± 1.47 | 1.53 ± 1.95 | 2.42 ± 2.63 | 1.75 ± 2.08 | <0.001 |
Satellite nodules | <0.001 | 0.016 | <0.001 | ||||||||||||
No | 96.1 | 97.2 | 89.1 | 89.9 | 94.5 | 92.7 | 93.5 | 86.9 | 89.3 | 85.5 | 79.1 | 80.8 | |||
Yes | 0.5 | 0 | 8.7 | 2.9 | 2.8 | 3.7 | 3.7 | 6.5 | 0.8 | 1.1 | 2.7 | 1.5 | |||
Unknown | 3.4 | 2.8 | 2.2 | 7.2 | 2.7 | 3.7 | 2.8 | 6.5 | 9.9 | 13.4 | 18.3 | 17.7 | |||
Ulceration | <0.001 | 0.025 | <0.001 | ||||||||||||
No | 88.8 | 85.6 | 67.4 | 82.6 | 70.5 | 65.3 | 62.3 | 60.7 | 78.0 | 72.2 | 60.0 | 65.5 | |||
Yes | 2.9 | 2.8 | 8.7 | 4.3 | 24.6 | 29.0 | 33.0 | 33.3 | 6.6 | 9.7 | 15.1 | 10.0 | |||
Unknown | 8.3 | 11.6 | 23.9 | 13.0 | 4.8 | 5.7 | 4.7 | 6.0 | 15.3 | 18.2 | 24.9 | 24.5 | |||
Lymph node extension | <0.001 | 0.001 | <0.001 | ||||||||||||
None | 75.8 | 75.6 | 63.0 | 69.6 | 68.0 | 70.3 | 69.3 | 60.7 | 71.6 | 66.6 | 49.4 | 54.1 | |||
Regional | 0.7 | 1.2 | 6.5 | 4.3 | 14.9 | 20.0 | 11.6 | 23.2 | 4.8 | 8.6 | 14.1 | 9.3 | |||
Distant | 0.1 | 0 | 2.2 | 1.4 | 0.9 | 41.3 | 1.4 | 0 | 0.8 | 1.2 | 2.7 | 2.3 | |||
Unknown | 23.4 | 23.2 | 28.3 | 24.6 | 16.2 | 8.3 | 17.7 | 16.1 | 22.8 | 23.6 | 33.9 | 34.3 | |||
Stage | <0.001 | 0.005 | <0.001 | ||||||||||||
In situ | - | - | - | - | - | - | - | - | - | - | - | - | |||
Localized | 93.5 | 93.2 | 73.9 | 85.5 | 67.7 | 60.7 | 66.5 | 53.0 | 77.3 | 66.3 | 44.7 | 57.7 | |||
Regional | 3.2 | 3.2 | 17.4 | 8.7 | 27.2 | 31.3 | 26.5 | 39.9 | 8.8 | 14.6 | 21.1 | 15.3 | |||
Distant | 0.3 | 0.4 | 4.3 | 1.4 | 3.3 | 4.3 | 4.7 | 5.4 | 6.3 | 10.3 | 20.6 | 16.4 | |||
Unstaged | 2.9 | 3.2 | 4.3 | 4.3 | 1.8 | 3.7 | 2.3 | 1.8 | 7.7 | 8.8 | 13.7 | 10.6 | |||
Treatment | 0.016 | 0.028 | <0.001 | ||||||||||||
No treatment | 2.1 | 4.0 | 4.3 | 1.4 | 1.8 | 2.7 | 3.3 | 0.6 | 6.1 | 11.2 | 15.4 | 12.1 | |||
Surgery | 96.2 | 94.8 | 93.5 | 92.8 | 96.8 | 94.3 | 94.4 | 94.6 | 88.7 | 82.5 | 73.0 | 78.0 | |||
Radiation | 0.1 | 0 | 0 | 1.4 | 0.2 | 0.3 | 0 | 0.6 | 1.7 | 2.0 | 4.8 | 3.9 | |||
Radiation & Surgery | 0.9 | 0.4 | 0 | 2.9 | 1.3 | 2.3 | 2.3 | 3.6 | 2.5 | 3.6 | 4.1 | 4.4 | |||
Unknown | 0.6 | 0.8 | 2.2 | 1.4 | 0 | 0.3 | 0 | 0.6 | 1.1 | 0.7 | 2.8 | 1.5 | |||
Survival time (month) | 181.9 ± 2.0 | 188.7 ± 14.2 | 153.0 ± 21.9 | 237.3 ± 25.1 | 0.138 | 158.4 ± 4.0 | 154.4 ± 10.4 | 133.4 ± 9.9 | 130.1 ± 12.1 | 0.023 | 243.0 ± 0.9 | 237.9 ± 5.8 | 144.6 ± 8.9 | 215.3 ± 10.1 | <0.001 |
Statistical analysis
Results
Patients’ clinicopathologic characteristics
Incidence
NHW | HW | Black | Asian/PI | Total | |
---|---|---|---|---|---|
Melanoma in situ | |||||
All ages | 9.19 (9.11–9.28) | 1.26 (1.18–1.35) | 0.16 (0.13–0.20) | 0.34 (0.30–0.38) | 6.60 (6.54–6.66) |
<40 years | 2.18 (2.12–2.24) | 0.21 (0.18–0.24) | 0.03 (0.02–0.05) | 0.10 (0.08–0.13) | 1.31 (1.27–1.34) |
40–64 years | 13.97 (13.78–14.16) | 1.61 (1.47–1.76) | 0.19 (0.14–0.26) | 0.48 (0.40–0.57) | 9.82 (9.69–9.94) |
65+ years | 29.35 (28.93–29.77) | 5.14 (4.63–5.70) | 0.67 (0.49–0.90) | 1.07 (0.87–1.31) | 22.72 (22.41–23.04) |
Male | 10.71 (10.58–10.85) | 1.22 (1.09–1.35) | 0.19 (0.14–0.26) | 0.35 (0.29–0.42) | 7.95 (7.85–8.05) |
Female | 8.33 (8.22–8.45) | 1.37 (1.26–1.48) | 0.15 (0.11–0.19) | 0.34 (0.29–0.39) | 5.77 (5.70–5.85) |
Superficial spreading melanoma | |||||
All ages | 9.05 (8.96–9.13) | 1.12 (1.05–1.19) | 0.15 (0.12–0.18) | 0.31 (0.27–0.35) | 6.18 (6.13–6.24) |
<40 years | 3.35 (3.27–3.42) | 0.35 (0.32–0.39) | 0.04 (0.02–0.06) | 0.11 (0.08–0.14) | 1.96 (1.92–2.00) |
40–64 years | 14.73 (14.54–14.93) | 1.81 (1.66–1.97) | 0.20 (0.15–0.27) | 0.47 (0.39–0.56) | 10.04 (9.91–10.17) |
65+ years | 21.09 (20.74–21.45) | 2.91 (2.53–3.33) | 0.51 (0.35–0.71) | 0.81 (0.64–1.02 | 15.93 (15.67–16.20) |
Male | 10.23 (10.10–10.37) | 0.98 (0.88–1.09) | 0.18 (0.13–0.24) | 0.34 (0.28–0.41) | 7.20 (7.11–7.29) |
Female | 8.27 (8.16–8.39) | 1.29 (1.19–1.39) | 0.13 (0.09–0.17) | 0.29 (0.24–0.34) | 5.49 (5.42–5.57) |
Nodular melanoma | |||||
All ages | 1.80 (1.76–1.84) | 0.49 (0.44–0.54) | 0.06 (0.04–0.08) | 0.14 (0.12–0.17) | 1.30 (1.28–1.33) |
<40 years | 0.38 (0.35–0.40) | 0.08 (0.06–0.10) | 0.01 (0.00–0.02) | 0.04 (0.02–0.06) | 0.23 (0.21–0.24) |
40–64 years | 2.31 (2.24–2.39) | 0.51 (0.43–0.60) | 0.06 (0.03–0.10) | 0.14 (0.10–0.19) | 1.60 (1.55–1.65) |
65+ years | 6.98 (6.78–7.19) | 2.26 (1.92–2.65) | 0.31 (0.19–0.48) | 0.63 (0.47–0.82) | 5.46 (5.30–5.61) |
Male | 2.51 (2.45–2.58) | 0.60 (0.51–0.70) | 0.07 (0.04–0.12) | 0.19 (0.14–0.24) | 1.84 (1.80–1.89) |
Female | 1.26 (1.22–1.30) | 0.42 (0.36–0.48) | 0.05 (0.03–0.08) | 0.11 (0.08–0.15) | 0.91 (0.88–0.93) |
Lentigo maligna melanoma | |||||
All ages | 1.87 (1.83–1.90) | 0.23 (0.19–0.27) | 0.02 (0.01–0.04) | 0.06 (0.05–0.08) | 1.37 (1.35–1.40) |
<40 years | 0.05 (0.04–0.06) | 0.01 (0.00–0.01) | 0.00 | 0.01 (0.00–0.02) | 0.03 (0.03–0.04) |
40–64 years | 1.83 (1.77–1.90) | 0.17 (0.13–0.23) | 0.01 (0.00–0.04) | 0.05 (0.03–0.09) | 1.26 (1.22–1.31) |
65+ years | 10.11 (9.87–10.36) | 1.38 (1.11–1.69) | 0.16 (0.08–0.29) | 0.33 (0.22–0.47) | 7.69 (7.51–7.87) |
Male | 2.97 (2.90–3.04) | 0.33 (0.26–0.41) | 0.04 (0.02–0.08) | 0.09 (0.06–0.13) | 2.21 (2.16–2.26) |
Female | 1.05 (1.02–1.09) | 0.17 (0.13–0.21) | 0.01 (0.00–0.03) | 0.04 (0.02–0.06) | 0.77 (0.74–0.80) |
Acral lentiginous melanoma, malignant | |||||
All ages | 0.21 (0.20–0.22) | 0.24 (0.21–0.28) | 0.19 (0.16–0.23) | 0.17 (0.14–0.20) | 0.20 (0.19–0.22) |
<40 years | 0.04 (0.03–0.05) | 0.02 (0.01–0.02) | 0.02 (0.01–0.03) | 0.02 (0.01–0.03) | 0.03 (0.03–0.04) |
40–64 years | 0.25 (0.23–0.28) | 0.26 (0.20–0.32) | 0.21 (0.16–0.28) | 0.17 (0.13–0.23) | 0.24 (0.22–0.26) |
65+ years | 0.87 (0.80–0.95) | 1.24 (0.99–1.54) | 0.93 (0.71–1.20) | 0.85 (0.67–1.07) | 0.90 (0.84–0.96) |
Male | 0.22 (0.20–0.24) | 0.25 (0.19–0.31) | 0.22 (0.16–0.30) | 0.20 (0.16–0.26) | 0.22 (0.20–0.23) |
Female | 0.21 (0.19–0.23) | 0.24 (0.20–0.30) | 0.18 (0.14–0.22) | 0.14 (0.11–0.18) | 0.20 (0.18–0.21) |
Malignant melanoma, NOS | |||||
All ages | 11.73 (11.64–11.83) | 2.25 (2.14–2.36) | 0.51 (0.45–0.57) | 0.66 (0.60–0.72) | 8.36 (8.29–8.42) |
<40 years | 3.37 (3.30–3.44) | 0.48 (0.44–0.53) | 0.10 (0.07–0.13) | 0.17 (0.14–0.21) | 2.02 (1.98–2.07) |
40–64 years | 17.35 (17.14–17.56) | 2.98 (2.78–3.18) | 0.57 (0.48–0.67) | 0.83 (0.72–0.94) | 12.10 (11.96–12.24) |
65+ years | 35.91 (35.45–36.38) | 8.46 (7.79–9.18) | 2.22 (1.87–2.62) | 2.42 (2.11–2.77) | 27.92 (27.58–28.28) |
Male | 14.63 (14.47–14.79) | 2.31 (2.13–2.49) | 0.63 (0.53–0.75) | 0.69 (0.61–0.79) | 10.68 (10.57–10.80) |
Female | 9.70 (9.58–9.82) | 2.30 (2.16–2.44) | 0.43 (0.36–0.50) | 0.64 (0.57–0.72) | 6.74 (6.66–6.82) |
Treatment
NHW | HW | Black | Asian/PI | P-value | ||
---|---|---|---|---|---|---|
Melanoma in situ | ||||||
In situ | No treatment | 3641 (4.2) | 109 (5.8) | 11 (5.0) | 17 (4.2) | 0.142 |
Surgery | 83560 (95.3) | 1770 (93.8) | 210 (95.0) | 385 (95.5) | ||
Radiation | 117 (0.1) | 2 (0.1) | 0 | 1 (0.2) | ||
Radiation & Surgery | 354 (0.4) | 6 (0.3) | 0 | 0 | ||
Superficial spreading melanoma | ||||||
Localized | No treatment | 1106 (1.4) | 38 (2.1) | 3 (1.6) | 8 (2.5) | 0.877 |
Surgery | 76782 (98.0) | 1764 (97.5) | 183 (97.9) | 306 (95.6) | ||
Radiation | 16 (0.0) | 0 | 0 | 0 | ||
Radiation & Surgery | 440 (0.6) | 7 (0.4) | 1 (0.5) | 6 (1.9) | ||
Regional | No treatment | 19 (0.4) | 0 | 0 | 0 | 0.999 |
Surgery | 4366 (95.4) | 142 (96.6) | 20 (95.2) | 34 (97.1) | ||
Radiation | 4 (0.1) | 0 | 0 | 0 | ||
Radiation & Surgery | 188 (4.1) | 5 (3.4) | 1 (4.8) | 1 (2.9) | ||
Distant | No treatment | 15 (4.2) | 0 | 0 | 0 | 0.650 |
Surgery | 259 (73.4) | 12 (80.0) | 1 (50.0) | 3 (100.0) | ||
Radiation | 9 (2.5) | 0 | 0 | 0 | ||
Radiation & Surgery | 70 (19.8) | 3 (20.0) | 1 (50.0) | 0 | ||
Nodular melanoma | ||||||
Localized | No treatment | 149 (1.3) | 5 (1.4) | 2 (4.5) | 1 (1.2) | 0.585 |
Surgery | 11613 (97.5) | 344 (98.0) | 42 (95.5) | 81 (97.6) | ||
Radiation | 12 (0.1) | 0 | 0 | 1 (1.2) | ||
Radiation & Surgery | 137 (1.2) | 2 (0.6) | 0 | 0 | ||
Regional | No treatment | 41 (0.7) | 2 (0.7) | 0 | 0 | 0.571 |
Surgery | 5792 (94.2) | 259 (93.8) | 39 (95.1) | 63 (95.5) | ||
Radiation | 2 (0.0) | 0 | 0 | 1 (1.5) | ||
Radiation & Surgery | 312 (5.1) | 15 (5.4) | 2 (4.9) | 2 (3.0) | ||
Distant | No treatment | 42 (5.3) | 4 (8.2) | 0 | 0 | 0.346 |
Surgery | 553 (70.3) | 40 (81.6) | 11 (73.3) | 6 (66.7) | ||
Radiation | 9 (1.1) | 0 | 0 | 0 | ||
Radiation & Surgery | 183 (23.3) | 5 (10.2) | 4 (26.7) | 3 (33.3) | ||
Lentigo maligna melanoma | ||||||
Localized | No treatment | 301 (1.9) | 7 (3.0) | 1 (2.9) | 0 | 0.986 |
Surgery | 15617 (97.4) | 224 (96.6) | 33 (97.1) | 56 (96.6) | ||
Radiation | 5 (0.0) | 0 | 0 | 1 (1.7) | ||
Radiation & Surgery | 104 (0.6) | 1 (0.4) | 0 | 1 (1.7) | ||
Regional | No treatment | 4 (0.7) | 0 | 1 (12.5) | 0 | 0.759 |
Surgery | 513 (92.9) | 8 (100.0) | 7 (87.5) | 5 (83.3) | ||
Radiation | - | - | - | - | ||
Radiation & Surgery | 35 (6.3) | 0 | 0 | 1 (16.7) | ||
Distant | No treatment | 2 (3.4) | 0 | 0 | 0 | 0.992 |
Surgery | 40 (69.0) | 1 (100.0) | 2 (100.0) | 1 (100.0) | ||
Radiation | 2 (3.4) | 0 | 0 | 0 | ||
Radiation & Surgery | 14 (24.1) | 0 | 0 | 0 | ||
Acral lentiginous melanoma, malignant | ||||||
Localized | No treatment | 23 (1.9) | 3 (1.6) | 5 (3.5) | 1 (1.1) | 0.841 |
Surgery | 1201 (97.3) | 178 (97.8) | 138 (96.5) | 87 (97.8) | ||
Radiation | 2 (0.2) | 0 | 0 | 0 | ||
Radiation & Surgery | 8 (0.6) | 1 (0.5) | 1 (0.5) | 1 (1.1) | ||
Regional | No treatment | 3 (0.6) | 0 | 1 (1.8) | 0 | 0.301 |
Surgery | 481 (97.2) | 89 (94.7) | 54 (94.7) | 65 (97.0) | ||
Radiation | - | - | - | - | ||
Radiation & Surgery | 11 (2.2) | 5 (5.3) | 2 (3.5) | 2 (3.0) | ||
Distant | No treatment | 1 (1.6) | 1 (7.7) | 0 | 0 | 0.022 |
Surgery | 54 (88.5) | 11 (84.6) | 7 (70.0) | 5 (55.6) | ||
Radiation | 1 (1.6) | 1 (7.7) | 0 | 1 (11.1) | ||
Radiation & Surgery | 5 (8.2) | 0 | 3 (33.3) | 3 (30.0) | ||
Malignant melanoma, NOS | ||||||
Localized | No treatment | 1950 (2.0) | 84 (3.3) | 14 (4.0) | 18 (3.6) | <0.001 |
Surgery | 95929 (97.4) | 2425 (96.2) | 330 (94.6) | 475 (95.6) | ||
Radiation | 70 (0.1) | 0 | 2 (0.6) | 0 | ||
Radiation & Surgery | 591 (0.6) | 13 (0.5) | 3 (0.9) | 4 (0.8) | ||
Regional | No treatment | 882 (7.9) | 52 (9.4) | 2 (1.2) | 7 (5.3) | 0.010 |
Surgery | 9397 (84.3) | 451 (81.7) | 153 (92.2) | 116 (87.9) | ||
Radiation | 69 (0.6) | 7 (1.3) | 1 (0.6) | 1 (0.8) | ||
Radiation & Surgery | 801 (7.2) | 42 (7.6) | 10 (6.0) | 8 (6.1) | ||
Distant | No treatment | 2901 (37.5) | 175 (44.9) | 71 (46.1) | 50 (37.6) | <0.001 |
Surgery | 2136 (27.6) | 97 (24.9) | 51 (33.1) | 40 (30.1) | ||
Radiation | 1192 (15.4) | 48 (12.3) | 17 (11.0) | 25 (18.8) | ||
Radiation & Surgery | 1501 (19.4) | 70 (17.9) | 15 (9.7) | 18 (13.5) |
Survival
Total | NHW | HW | Black | Asian/PI | P-value | |
---|---|---|---|---|---|---|
Melanoma in situ | ||||||
In situ | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 0.380 |
Superficial spreading melanoma | ||||||
Localized | 99.2 (98.9–99.4) | 99.0 (98.7–99.2) | 98.2 (96.1–99.2) | 100.0 | 94.0 (87.7–97.1) | 0.844 |
Regional | 71.5 (69.7–73.2) | 71.4 (69.6–73.2) | 74.1 (62.9–82.4) | 67.5 (33.5–86.8) | 60.7 (40.0–76.3) | 0.623 |
Distant | 33.8 (27.7–40.0) | 33.0 (26.7–39.5) | 46.8 (18.1–71.4) | 0.0 | 33.7 (0.9–77.9) | 0.987 |
Nodular melanoma | ||||||
Localized | 80.6 (79.5–81.7) | 80.6 (79.4–81.7) | 79.7 (72.4–85.4) | 63.9 (39.0–80.8) | 72.9 (56.8–83.8) | 0.403 |
Regional | 55.1 (53.4–56.7) | 55.3 (53.6–57.0) | 47.6 (39.5–55.1) | 46.5 (24.7–65.7) | 62.9 (46.9–75.3) | 0.119 |
Distant | 17.1 (13.9–20.6) | 16.2 (12.9–19.7) | 34.4 (17.6–51.9) | 27.1 (4.9–56.8) | 13.3 (0.7–44.3) | 0.101 |
Lentigo maligna melanoma | ||||||
Localized | 100.0 | 100.0 | 97.3 (61.0–99.8) | 100.0 | 96.1 (53.3–99.8) | 0.697 |
Regional | 73.2 (65.6–79.4) | 75.6 (67.7–81.8) | 58.1 (3.7–91.5) | 19.1 (0.8–56.9) | 31.7 (0.7–76.9) | 0.151 |
Distant | 26.1 (11.3–43.8) | 24.2 (9.5–42.4) | 0.0 | 69.4 (0.0–99.2) | 0.0 | 0.508 |
Acral lentiginous melanoma, malignant | ||||||
Localized | 96.0 (92.6–97.8) | 97.5 (92.4–99.2) | 95.0 (75.3–99.1) | 91.9 (74.9–97.6) | 87.4 (70.7–94.9) | 0.266 |
Regional | 58.4 (52.9–63.5) | 60.3 (53.5–66.5) | 50.6 (37.0–62.7) | 49.8 (29.3–67.3) | 62.1 (44.5–75.5) | 0.447 |
Distant | 15.8 (7.7–26.5) | 13.8 (4.8–27.5) | 12.0 (0.7–40.7) | 28.7 (4.9–59.7) | 20.3 (0.8–58.8) | 0.651 |
Malignant melanoma, NOS | ||||||
Localized | 97.3 (97.1–97.6) | 97.2 (96.9–97.5) | 95.6 (93.7–96.9) | 86.0 (78.2–91.1) | 93.1 (88.6–95.9) | 0.013 |
Regional | 61.1 (59.8–62.2) | 61.4 (60.2–62.7) | 57.0 (51.4–62.2) | 48.1 (37.7–57.7) | 53.8 (42.8–63.6) | 0.007 |
Distant | 14.3 (13.4–15.3) | 14.1 (13.1–15.1) | 17.0 (12.5–22.1) | 16.4 (9.7–24.6) | 9.6 (4.6–16.7) | 0.501 |
In situ | Localized | Regional | Distant | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
HR | 95 % CI |
P
| HR | 95 % CI |
P
| HR | 95 % CI |
P
| HR | 95 % CI |
P
| |
Melanoma in situ | ||||||||||||
Gender | - | - | - | - | - | - | - | - | - | |||
Male | 1 | - | - | - | - | - | - | - | - | - | ||
Female | 0.502 | 0.398–0.634 | 0.000 | - | - | - | - | - | - | - | - | - |
Age at diagnosis | 1.098 | 1.087–1.110 | 0.000 | - | - | - | - | - | - | - | - | - |
Marital Status | - | - | - | - | - | - | - | - | - | |||
Single | 1 | - | - | - | - | - | - | - | - | - | ||
Married | 0.770 | 0.539–1.099 | 0.150 | - | - | - | - | - | - | - | - | - |
Separated/divorced/widowed | 1.225 | 0.831–1.806 | 0.305 | - | - | - | - | - | - | - | - | - |
Ethnic group | - | - | - | - | - | - | - | - | - | |||
NHW | 1 | - | - | - | - | - | - | - | - | - | ||
HW | 1.886 | 0.888–4.006 | 0.099 | - | - | - | - | - | - | - | - | - |
Black | 0.709 | 0.098–5.115 | 0.733 | - | - | - | - | - | - | - | - | - |
Asian/PI | 0.624 | 0.087–4.495 | 0.640 | - | - | - | - | - | - | - | - | - |
Anatomic Site | - | - | - | - | - | - | - | - | - | |||
Face/head/neck | 1 | - | - | - | - | - | - | - | - | - | ||
Trunk | 0.993 | 0.783–1.259 | 0.952 | - | - | - | - | - | - | - | - | - |
Upper Extremity | 0.876 | 0.668–1.149 | 0.338 | - | - | - | - | - | - | - | - | - |
Lower Extremity | 0.753 | 0.500–1.133 | 0.174 | - | - | - | - | - | - | - | - | - |
Other | 1.081 | 0.399–2.929 | 0.878 | - | - | - | - | - | - | - | - | - |
Treatment | - | - | - | - | - | - | - | - | - | |||
No surgery or radiation | 1 | - | - | - | - | - | - | - | - | - | ||
Surgery | 1.125 | 0.531–2.387 | 0.758 | - | - | - | - | - | - | - | - | - |
Radiation | 0.185 | -- | 0.989 | - | - | - | - | - | - | - | - | - |
Radiation & Surgery | 1.041 | 0.214–5.063 | 0.961 | - | - | - | - | - | - | - | - | - |
Thickness of tumor (mm) | 1.043 | 0.993–1.095 | 0.091 | - | - | - | - | - | - | - | - | - |
Ulceration | - | - | - | - | - | - | - | - | - | |||
No | 1 | - | - | - | - | - | - | - | - | - | ||
Yes | 1.722 | 0.847–3.503 | 0.133 | - | - | - | - | - | - | - | - | - |
Superficial spreading melanoma | ||||||||||||
Gender | ||||||||||||
Male | - | - | - | 1 | 1 | 1 | ||||||
Female | - | - | - | 0.709 | 0.677–0.742 | 0.000 | 0.718 | 0.644–0.801 | 0.000 | 0.657 | 0.452–0.955 | 0.028 |
Age at diagnosis | - | - | - | 1.074 | 1.072–1.075 | 0.000 | 1.033 | 1.029–1.036 | 0.000 | 1.018 | 1.007–1.029 | 0.001 |
Marital Status | ||||||||||||
Single | - | - | - | 1 | 1 | 1 | ||||||
Married | - | - | - | 0.741 | 0.693–0.792 | 0.000 | 0.724 | 0.631–0.832 | 0.000 | 0.505 | 0.337–0.757 | 0.001 |
Separated/divorced/widowed | - | - | - | 1.034 | 0.957–1.117 | 0.400 | 0.897 | 0.759–1.059 | 0.199 | 0.791 | 0.480–1.301 | 0.355 |
Ethnic group | ||||||||||||
NHW | - | - | - | 1 | 1 | 1 | ||||||
HW | - | - | - | 1.065 | 0.915–1.241 | 0.416 | 1.213 | 0.909–1.620 | 0.190 | 0.931 | 0.468–1.850 | 0.837 |
Black | - | - | - | 0.920 | 0.605–1.398 | 0.696 | 0.954 | 0.549–1.657 | 0.867 | 1.171 | 0.156–8.812 | 0.878 |
Asian/PI | - | - | - | 1.008 | 0.726–1.398 | 0.964 | 1.028 | 0.606–1.745 | 0.918 | 0.821 | 0.196–3.447 | 0.788 |
Anatomic Site | ||||||||||||
Face/head/neck | - | - | - | 1 | 1 | 1 | ||||||
Trunk | - | - | - | 0.849 | 0.804–0.896 | 0.000 | 0.896 | 0.788–1.020 | 0.098 | 1.570 | 1.062–2.319 | 0.024 |
Upper Extremity | - | - | - | 0.750 | 0.707–0.795 | 0.000 | 0.800 | 0.692–0.925 | 0.003 | 1.606 | 1.034–2.493 | 0.035 |
Lower Extremity | - | - | - | 0.655 | 0.611–0.701 | 0.000 | 0.820 | 0.707–0.951 | 0.009 | 1.384 | 0.825–2.323 | 0.218 |
Other | - | - | - | 1.031 | 0.731–1.455 | 0.860 | 1.359 | 0.507–3.646 | 0.542 | 0.000 | -- | 0.954 |
Treatment | ||||||||||||
No surgery or radiation | - | - | - | 1 | 1 | 1 | ||||||
Surgery | - | - | - | 0.584 | 0.468–0.729 | 0.000 | 2.030 | 0.652–6.316 | 0.222 | 0.274 | 0.116–0.645 | 0.003 |
Radiation | - | - | - | 1.738 | 0.427–7.077 | 0.440 | 5.760 | 0.597–55.57 | 0.130 | 1.454 | 0.397–5.328 | 0.572 |
Radiation & Surgery | - | - | - | 1.175 | 0.841–1.640 | 0.345 | 4.154 | 1.316–13.11 | 0.015 | 0.750 | 0.306–1.836 | 0.529 |
Thickness of tumor (mm) | - | - | - | 1.223 | 1.207–1.239 | 0.000 | 1.152 | 1.128–1.176 | 0.000 | 1.107 | 1.043–1.175 | 0.001 |
Ulceration | ||||||||||||
No | - | - | - | 1 | 1 | 1 | ||||||
Yes | - | - | - | 1.355 | 1.226–1.498 | 0.000 | 1.082 | 0.984–1.190 | 0.102 | 1.011 | 0.703–1.453 | 0.954 |
Nodular melanoma | ||||||||||||
Gender | ||||||||||||
Male | - | - | - | 1 | 1 | 1 | ||||||
Female | - | - | - | 0.753 | 0.698–0.812 | 0.000 | 0.790 | 0.728–0.858 | 0.000 | 1.069 | 0.879–1.299 | 0.504 |
Age at diagnosis | - | - | - | 1.048 | 1.045–1.050 | 0.000 | 1.028 | 1.026–1.031 | 0.000 | 1.010 | 1.004–1.015 | 0.001 |
Marital Status | ||||||||||||
Single | - | - | - | 1 | 1 | 1 | ||||||
Married | - | - | - | 0.707 | 0.636–0.785 | 0.000 | 0.799 | 0.722–0.885 | 0.000 | 0.763 | 0.600–0.970 | 0.027 |
Separated/divorced/widowed | - | - | - | 0.944 | 0.838–1.063 | 0.341 | 1.001 | 0.887–1.129 | 0.987 | 0.880 | 0.663–1.167 | 0.374 |
Ethnic group | ||||||||||||
NHW | - | - | - | 1 | 1 | 1 | ||||||
HW | - | - | - | 0.924 | 0.739–1.155 | 0.486 | 1.150 | 0.958–1.380 | 0.134 | 0.625 | 0.416–0.940 | 0.024 |
Black | - | - | - | 1.533 | 0.887–2.647 | 0.126 | 1.335 | 0.876–2.035 | 0.179 | 0.597 | 0.243–1.467 | 0.261 |
Asian/PI | - | - | - | 0.938 | 0.597–1.475 | 0.783 | 0.781 | 0.540–1.128 | 0.187 | 0.959 | 0.469–1.961 | 0.910 |
Anatomic Site | ||||||||||||
Face/head/neck | - | - | - | 1 | 1 | 1 | ||||||
Trunk | - | - | - | 1.046 | 0.957–1.143 | 0.320 | 1.125 | 1.023–1.238 | 0.016 | 1.284 | 1.027–1.605 | 0.029 |
Upper Extremity | - | - | - | 0.846 | 0.773–0.926 | 0.000 | 0.901 | 0.813–0.998 | 0.046 | 0.960 | 0.745–1.237 | 0.750 |
Lower Extremity | - | - | - | 0.832 | 0.743–0.931 | 0.001 | 0.984 | 0.879–1.101 | 0.775 | 0.936 | 0.711–1.232 | 0.636 |
Other | - | - | - | 0.974 | 0.572–1.660 | 0.923 | 0.940 | 0.518–1.705 | 0.838 | 3.880 | 0.942–15.986 | 0.061 |
Treatment | ||||||||||||
No surgery or radiation | - | - | - | 1 | 1 | 1 | ||||||
Surgery | - | - | - | 0.498 | 0.358–0.692 | 0.000 | 0.416 | 0.276–0.628 | 0.000 | 0.459 | 0.282–0.748 | 0.002 |
Radiation | - | - | - | 1.813 | 0.644–5.102 | 0.260 | 0.418 | 0.056–3.102 | 0.394 | 0.626 | 0.210–1.866 | 0.400 |
Radiation & Surgery | - | - | - | 1.012 | 0.667–1.536 | 1.012 | 0.648 | 0.419–1.003 | 0.051 | 0.678 | 0.409–1.124 | 0.132 |
Thickness of tumor (mm) | - | - | - | 1.120 | 1.104–1.136 | 0.000 | 1.074 | 1.060–1.088 | 0.000 | 1.017 | 0.989–1.044 | 0.235 |
Ulceration | ||||||||||||
No | - | - | - | 1 | 1 | 1 | ||||||
Yes | - | - | - | 1.215 | 1.116–1.323 | 0.000 | 1.074 | 1.000–1.155 | 0.051 | 0.834 | 0.699–0.997 | 0.046 |
Lentigo maligna melanoma | ||||||||||||
Gender | ||||||||||||
Male | - | - | - | 1 | 1 | 1 | ||||||
Female | - | - | - | 0.641 | 0.589–0.698 | 0.000 | 0.641 | 0.471–0.872 | 0.005 | 1.968 | 0.468–8.271 | 0.355 |
Age at diagnosis | - | - | - | 1.093 | 1.088–1.097 | 0.000 | 1.050 | 1.036–1.065 | 0.000 | 1.016 | 0.965–1.070 | 0.550 |
Marital Status | ||||||||||||
Single | - | - | - | 1 | 1 | 1 | ||||||
Married | - | - | - | 0.758 | 0.660–0.870 | 0.000 | 0.858 | 0.508–1.449 | 0.566 | 1.701 | 0.345–8.396 | 0.514 |
Separated/divorced/widowed | - | - | - | 0.939 | 0.808–1.091 | 0.409 | 1.137 | 0.657–1.969 | 0.646 | 0.744 | 0.082–6.771 | 0.793 |
Ethnic group | ||||||||||||
NHW | - | - | - | 1 | 1 | 1 | ||||||
HW | - | - | - | 0.981 | 0.723–1.330 | 0.900 | 0.619 | 0.196–1.954 | 0.414 | - | - | - |
Black | - | - | - | 1.029 | 0.486–2.180 | 0.940 | 9.996 | 1.239–80.642 | 0.031 | 0.308 | 0.009–10.073 | 0.508 |
Asian | - | - | - | 0.587 | 0.244–1.412 | 0.234 | 1.120 | 0.331–3.793 | 0.855 | - | - | - |
Anatomic Site | ||||||||||||
Face/head/neck | - | - | - | 1 | 1 | 1 | ||||||
Trunk | - | - | - | 0.909 | 0.812–1.018 | 0.099 | 1.068 | 0.666–1.713 | 0.785 | 5.787 | 1.173-28.562 | 0.031 |
Upper Extremity | - | - | - | 0.888 | 0.806–0.978 | 0.016 | 0.988 | 0.656–1.488 | 0.954 | 1.564 | 0.145–16.844 | 0.712 |
Lower Extremity | - | - | - | 0.802 | 0.655–0.981 | 0.032 | 0.670 | 0.363–1.234 | 0.198 | - | - | - |
Other | - | - | - | 1.218 | 0.792–1.873 | 0.369 | - | - | - | - | - | - |
Treatment | ||||||||||||
No surgery or radiation | - | - | - | 1 | 1 | - | - | - | ||||
Surgery | - | - | - | 0.734 | 0.530–1.015 | 0.062 | 1.768 | 0.245–12.759 | 0.572 | 1 | ||
Radiation | - | - | - | 0.017 | -- | 0.902 | - | - | - | 135.011 | -- | 0.000 |
Radiation & Surgery | - | - | - | 1.202 | 0.703–2.056 | 0.501 | 3.478 | 0.445–27.195 | 0.235 | 7.513 | 1.689–33.427 | 0.008 |
Thickness of tumor (mm) | - | - | - | 1.130 | 1.098–1.162 | 0.000 | 1.094 | 1.030–1.161 | 0.003 | 1.142 | 0.893–1.460 | 0.289 |
Ulceration | ||||||||||||
No | - | - | - | 1 | 1 | 1 | ||||||
Yes | - | - | - | 1.243 | 0.971–1.592 | 0.085 | 1.242 | 0.949–1.626 | 0.114 | 2.834 | 0.458–17.545 | 0.263 |
Acral lentiginous melanoma, malignant | ||||||||||||
Gender | ||||||||||||
Male | - | - | - | 1 | 1 | 1 | ||||||
Female | - | - | - | 0.810 | 0.649–1.011 | 0.062 | 0.595 | 0.471–0.752 | 0.000 | 0.828 | 0.449–1.529 | 0.546 |
Age at diagnosis | - | - | - | 1.069 | 1.059–1.079 | 0.000 | 1.025 | 1.017–1.034 | 0.000 | 1.040 | 1.013–1.067 | 0.003 |
Marital Status | ||||||||||||
Single | - | - | - | 1 | 1 | 1 | ||||||
Married | - | - | - | 0.922 | 0.638–1.332 | 0.665 | 0.790 | 0.550–1.136 | 0.204 | 0.340 | 0.120–0.967 | 0.043 |
Separated/divorced/widowed | - | - | - | 1.063 | 0.719–1.572 | 0.761 | 1.093 | 0.744–1.606 | 0.652 | 0.337 | 0.099–1.147 | 0.082 |
Ethnic group | ||||||||||||
Non-Hispanic white | - | - | - | 1 | 1 | 1 | ||||||
Hispanic white | - | - | - | 0.771 | 0.530–1.123 | 0.176 | 1.219 | 0.884–1.682 | 0.228 | 0.987 | 0.409–2.381 | 0.977 |
Black | - | - | - | 1.112 | 0.803–1.540 | 0.523 | 1.080 | 0.751–1.553 | 0.678 | 0.601 | 0.254–1.420 | 0.246 |
Asian | - | - | - | 1.307 | 0.826–2.068 | 0.254 | 0.843 | 0.568–1.250 | 0.396 | 0.630 | 0.183–2.176 | 0.465 |
Anatomic Site | ||||||||||||
Face/head/neck | - | - | - | 1 | 1 | - | - | - | ||||
Trunk | - | - | - | 0.845 | 0.280–2.552 | 0.765 | 0.770 | 0.123–4.845 | 0.781 | 1 | ||
Upper Extremity | - | - | - | 0.978 | 0.447–2.140 | 0.956 | 0.933 | 0.275–3.162 | 0.912 | 0.253 | 0.045–1.403 | 0.116 |
Lower Extremity | - | - | - | 1.004 | 0.472–2.139 | 0.991 | 1.277 | 0.383–4.250 | 0.691 | 0.302 | 0.060–1.509 | 0.145 |
Other | - | - | - | 0.913 | 0.111–7.533 | 0.933 | 0.011 | -- | 0.962 | - | - | - |
Treatment | ||||||||||||
No surgery or radiation | - | - | - | 1 | 1 | 1 | ||||||
Surgery | - | - | - | 0.372 | 0.162–0.855 | 0.020 | 0.065 | 0.020–0.213 | 0.000 | 0.150 | 0.031–0.718 | 0.018 |
Radiation | - | - | - | 0.431 | 0.049–3.766 | 0.446 | - | - | - | 0.946 | 0.112–7.994 | 0.959 |
Radiation & Surgery | - | - | - | 0.151 | 0.018–1.271 | 0.082 | 0.179 | 0.047–0.687 | 0.012 | 0.528 | 0.091–3.061 | 0.476 |
Thickness of tumor (mm) | - | - | - | 1.137 | 1.072–1.206 | 0.000 | 1.115 | 1.069–1.163 | 0.000 | 1.094 | 0.988–1.211 | 0.083 |
Ulceration | ||||||||||||
No | - | - | - | 1 | 1 | 1 | ||||||
Yes | - | - | - | 1.544 | 1.112–2.143 | 0.009 | 1.103 | 0.888–1.368 | 0.376 | 2.281 | 1.216–4.280 | 0.010 |
Malignant melanoma, NOS | ||||||||||||
Gender | ||||||||||||
Male | - | - | - | 1 | 1 | 1 | ||||||
Female | - | - | - | 0.705 | 0.676–0.735 | 0.000 | 0.800 | 0.742–0.862 | 0.000 | 0.881 | 0.752–1.032 | 0.117 |
Age at diagnosis | - | - | - | 1.069 | 1.068–1.071 | 0.000 | 1.033 | 1.031–1.035 | 0.000 | 1.014 | 1.010–1.019 | 0.000 |
Marital Status | ||||||||||||
Single | - | - | - | 1 | 1 | 1 | ||||||
Married | - | - | - | 0.731 | 0.690–0.776 | 0.000 | 0.777 | 0.704–0.857 | 0.000 | 0.630 | 0.521–0.762 | 0.000 |
Separated/divorced/widowed | - | - | - | 0.985 | 0.921–1.054 | 0.660 | 0.993 | 0.886–1.114 | 0.910 | 0.848 | 0.673–1.069 | 0.163 |
Ethnic group | ||||||||||||
NHW | - | - | - | 1 | 1 | 1 | ||||||
HW | - | - | - | 1.134 | 1.002–1.284 | 0.046 | 1.240 | 1.056–1.455 | 0.009 | 0.970 | 0.704–1.336 | 0.852 |
Black | - | - | - | 1.389 | 1.086–1.777 | 0.009 | 1.372 | 1.056–1.782 | 0.018 | 0.859 | 0.516–1.431 | 0.561 |
Asian/PI | - | - | - | 1.004 | 0.782–1.290 | 0.973 | 1.052 | 0.772–1.434 | 0.748 | 1.478 | 0.850–2.571 | 0.167 |
Anatomic Site | ||||||||||||
Face/head/neck | - | - | - | 1 | 1 | 1 | ||||||
Trunk | - | - | - | 0.918 | 0.876–0.962 | 0.000 | 1.087 | 0.994–1.189 | 0.068 | 1.098 | 0.913–1.320 | 0.320 |
Upper Extremity | - | - | - | 0.811 | 0.772–0.852 | 0.000 | 0.859 | 0.779–0.948 | 0.003 | 0.970 | 0.782–1.203 | 0.778 |
Lower Extremity | - | - | - | 0.732 | 0.687–0.779 | 0.000 | 0.910 | 0.823–1.006 | 0.065 | 0.835 | 0.672–1.037 | 0.103 |
Other | - | - | - | 0.911 | 0.690–1.201 | 0.506 | 1.416 | 0.908–2.208 | 0.125 | 1.011 | 0.631–1.619 | 0.964 |
Treatment | ||||||||||||
No surgery or radiation | - | - | - | 1 | 1 | 1 | ||||||
Surgery | - | - | - | 0.656 | 0.572–0.752 | 0.000 | 0.392 | 0.291–0.530 | 0.000 | 0.472 | 0.357–0.626 | 0.000 |
Radiation | - | - | - | 2.551 | 1.424–4.570 | 0.002 | 1.886 | 0.886–4.016 | 0.100 | 1.647 | 1.033–2.625 | 0.036 |
Radiation & Surgery | - | - | - | 1.312 | 1.069–1.610 | 0.009 | 0.732 | 0.531–1.011 | 0.058 | 0.747 | 0.549–1.016 | 0.063 |
Thickness of tumor (mm) | - | - | - | 1.196 | 1.183–1.208 | 0.000 | 1.086 | 1.073–1.099 | 0.000 | 1.045 | 1.021–1.069 | 0.000 |
Ulceration | ||||||||||||
No | - | - | - | 1 | 1 | 1 | ||||||
Yes | - | - | - | 1.448 | 1.351–1.553 | 0.000 | 1.172 | 1.097–1.252 | 0.000 | 1.002 | 0.858–1.172 | 0.975 |