Background
Methods
Sequence and phenotypic data
Annotation files
Statistical analysis
Results
Overall empirical power and type I error
Phenotype | DBP | SBP | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
SNPs | All | Rare | All | Rare | ||||||||
Weight | Equal | M-B | Default | Equal | M-B | Default | Equal | M-B | Default | Equal | M-B | Default |
Type I Error | 0.047 | 0.043 | 0.043 | 0.044 | 0.042 | 0.043 | 0.048 | 0.048 | 0.049 | 0.048 | 0.050 | 0.049 |
Power |
0.053
| 0.050 | 0.048 | 0.048 | 0.050 | 0.048 |
0.054
| 0.053 | 0.053 | 0.049 | 0.052 | 0.052 |
Empirical power at causal genes
Correlation | All | Rare | |||||
---|---|---|---|---|---|---|---|
Equal | M-B | Default | Equal | M-B | Default | ||
All | Equal | 0.69 | 0.17 | 0.13 | 0.11 | 0.11 | |
M-B | 0.61 | 0.47 | 0.55 | 0.54 | |||
Default | 0.79 |
0.87
|
0.95
| ||||
Rare | Equal | 0.70 |
0.80
| ||||
M-B |
0.91
| ||||||
Default |
Causal Genes | Number of SNPs | Number of causal SNPs1 | Total % variance explained2 | All | Rare | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
All | Rare | All | Rare | Equal | M-B | Default | Equal | M-B | Default | ||
DBP
| |||||||||||
MAP4
| 542 | 392 | 6 | 5 | 0.04826 |
0.30
|
0.27
| 0.07 | 0.09 | 0.06 | 0.07 |
FLT3
| 639 | 308 | 4 | 2 | 0.01053 |
0.33
|
0.26
| 0.04 | 0.06 | 0.04 | 0.04 |
DHX8
| 142 | 89 | 2 | 2 | 0.00007 |
0.25
|
0.23
| 0.06 | 0.09 | 0.04 | 0.05 |
FGR
| 92 | 78 | 2 | 1 | 0.00006 |
0.33
| 0.12 | 0.16 | 0.18 | 0.11 | 0.16 |
TXNIP
| 9 | 6 | 1 | 1 | <1.0E-5 | 0.09 | 0.16 |
0.25
|
0.33
|
0.21
|
0.29
|
GLUL
| 44 | 24 | 2 | 2 | 0.00012 | 0.07 | 0.12 |
0.28
| 0.12 |
0.24
|
0.28
|
PDCD6IP
| 359 | 215 | 4 | 2 | 0.00058 | 0.04 | 0.06 |
0.29
| 0.15 |
0.33
|
0.30
|
DGKE
| 136 | 71 | 1 | 0 | 0.00005 | 0.02 | 0.05 |
0.23
| 0.05 |
0.28
|
0.25
|
PTTG1IP
| 174 | 116 | 2 | 2 | 0.00005 | 0.04 | 0.09 | 0.15 |
0.20
| 0.13 | 0.15 |
EPHA2
| 133 | 93 | 1 | 1 | 0.00021 | 0.03 | 0.17 | 0.11 | 0.03 |
0.20
| 0.10 |
SBP
| |||||||||||
MAP4
| 542 | 392 | 7 | 5 | 0.05824 |
0.27
|
0.27
| 0.14 | 0.17 | 0.09 | 0.14 |
FLT3
| 639 | 308 | 4 | 2 | 0.00841 |
0.20
| 0.18 | 0.04 | 0.04 | 0.03 | 0.03 |
DHX8
| 142 | 89 | 2 | 2 | 0.00002 |
0.25
|
0.25
| 0.02 | 0.10 | 0.03 | 0.03 |
S100A6
| 14 | 11 | 2 | 2 | 0.00003 |
0.27
| 0.09 | 0.06 | 0.05 | 0.05 | 0.05 |
KRT23
| 79 | 31 | 2 | 1 | 0.00016 |
0.24
|
0.24
| 0.04 | 0.03 | 0.02 | 0.02 |
TXNIP
| 9 | 6 | 1 | 1 | <1.0E-5 | 0.09 | 0.14 |
0.20
|
0.26
| 0.14 |
0.22
|
GLUL
| 44 | 24 | 2 | 2 | 0.00006 | 0.04 | 0.09 |
0.27
| 0.11 |
0.22
|
0.28
|
PDCD6IP
| 359 | 215 | 4 | 2 | 0.00027 | 0.04 | 0.08 |
0.33
| 0.17 |
0.36
|
0.33
|
SCAP
| 114 | 83 | 1 | 1 | 0.00003 | 0.06 | 0.17 |
0.40
|
0.39
|
0.24
|
0.36
|
EPHA2
| 133 | 93 | 1 | 1 | 0.00018 | 0.04 |
0.27
|
0.21
| 0.10 |
0.34
|
0.22
|