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Neurological Sciences

Erschienen in:

13.09.2021 | Original Article

Rate-dependent depression is impaired in amyotrophic lateral sclerosis

verfasst von: Xiajun Zhou, Ze Wang, Zhi Lin, Ying Zhu, Desheng Zhu, Chong Xie, Nigel A. Calcutt, Yangtai Guan

Erschienen in: Neurological Sciences | Ausgabe 3/2022

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Abstract

Objective

We investigated rate-dependent depression (RDD) of the Hoffman reflex (H-reflex) in patients with amyotrophic lateral sclerosis (ALS), a degenerative disease with ventral horn involvement.

Patients and methods

In this case–control study, we enrolled 27 patients with ALS and 30 matched healthy control subjects. Clinical and electrophysiological assessments, as well as RDD in response to various stimulation frequencies (0.5 Hz, 1 Hz, 3 Hz and 5 Hz), were compared between groups. Multiple clinical and electrophysiological factors were also explored to determine any underlying associations with RDD.

Results

The ALS group showed a significant loss of RDD across all frequencies compared to the control group, most notably following 1 Hz stimulation (19.1 ± 20.3 vs. 34.0 ± 13.7%, p = 0.003). Among factors that might influence RDD, the enlargement of the motor unit potential (MUP) showed a significant relationship with RDD following multifactor analysis of variance (p = 0.007) and Pearson correlation analysis (ρ = − 0.70, p < 0.001), while various upper motor neuron manifestations were not correlated with RDD values (p > 0.05).

Conclusion

We report a loss of RDD in patients with ALS. The strong correlation detected between the RDD deficit and increased MUP suggests that RDD is a sensitive indicator of underlying spinal disinhibition in ALS.

Trial registration

ChiCTR2000038848, 10/7/2020 (retrospectively registered), http://www.chictr.org.cn/.

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Titel: Rate-dependent depression is impaired in amyotrophic lateral sclerosis
verfasst von: Xiajun Zhou
Ze Wang
Zhi Lin
Ying Zhu
Desheng Zhu
Chong Xie
Nigel A. Calcutt
Yangtai Guan
Publikationsdatum: 13.09.2021
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 3/2022
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-021-05596-2

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Abstract

Objective

Patients and methods

Results

Conclusion

Trial registration

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