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Current Rheumatology Reports

Erschienen in:

01.09.2015 | Imaging (P Conaghan, Section Editor)

Recent Advances in Imaging of the Axial Skeleton in Spondyloarthritis for Diagnosis, Assessment of Treatment Effect, and Prognostication

verfasst von: Susanne Juhl Pedersen, Walter P. Maksymowych

Erschienen in: Current Rheumatology Reports | Ausgabe 9/2015

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Abstract

In the last few years, many studies have investigated the role of imaging for improved diagnosis, assessment of treatment effects, and determining prognosis in patients with axial spondyloarthritis (SpA). Recent research has primarily focused on the utility of magnetic resonance imaging (MRI) for improved diagnosis of patients with non-radiographic axial SpA, and in particular on the classification utility of the MRI criteria as defined by the Assessment of Spondyloarthritis International Society (ASAS). New and more sensitive methods for evaluation of MRI of the sacroiliac joints have been developed and have provided insight into effects of treatment on structural progression and the interrelationships between different lesions visualized by MRI. This review gives an overview of the recent advances in imaging of the axial skeleton in axial SpA from a clinical perspective.

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van den Berg R, Lenczner G, Thevenin F, Claudepierre P, Feydy A, Reijnierse M et al. Classification of axial SpA based on positive imaging (radiographs and/or MRI of the sacroiliac joints) by local rheumatologists or radiologists versus central trained readers in the DESIR cohort. Ann Rheum Dis 2014. The study investigates the consequence of the disagreement of local radiologist versus central trained readers in evaluation of conventional radiography and MRI for classification of patients with axial SpA according to the ASAS criteria.

12.••

van den Berg R, Lenczner G, Feydy A, Van Der Heijde D, Reijnierse M, Saraux A, et al. Agreement between clinical practice and trained central reading in reading of sacroiliac joints on plain pelvic radiographs. Results from the DESIR cohort. Arthritis Rheumatol. 2014;66:2403–11. This study investigates the agreement between local radiologist and central trained readers in reading conventional radiography according to the modified New York criteria.CrossRefPubMed

13.••

Jans L, Van PL, Elewaut D, Van Den Bosch F, Carron P, Jaremko JL, et al. MRI of the SI joints commonly shows non-inflammatory disease in patients clinically suspected of sacroiliitis. Eur J Radiol. 2014;83:179–84. Investigates the frequency of other conditions associated with sacroiliitis on MRI in patients suspected for axial SpA.CrossRefPubMed

14.••

Weber U, Zhao Z, Rufibach K, Zubler V, Lambert RG, Chan SM, et al. Diagnostic utility of candidate definitions for demonstrating axial spondyloarthritis on magnetic resonance imaging of the spine. Arthritis Rheumatol. 2015;67:924–33. Investigates the diagnostic utility of the ASAS definition of a positive MRI of the spine.CrossRefPubMed

15.••

Weber U, Ostergaard M, Lambert RG, Pedersen SJ, Chan SM, Zubler V et al. Candidate lesion-based criteria for defining a positive sacroiliac joint MRI in two cohorts of patients with axial spondyloarthritis. Ann Rheum Dis 2014. Data driven proposal for a definition of a positive MRI of the sacroiliac joints.

16.••

Weber U, Zubler V, Zhao Z, Lambert RG, Chan SM, Pedersen SJ, et al. Does spinal MRI add incremental diagnostic value to MRI of the sacroiliac joints alone in patients with non-radiographic axial spondyloarthritis? Ann Rheum Dis. 2015;74(6):985–92. Study on the additional value of MRI of the spine to MRI of the sacroiliac joints.CrossRefPubMed

17.••

Weber U, Pedersen SJ, Zubler V, Rufibach K, Chan SM, Lambert RG, et al. Fat infiltration on magnetic resonance imaging of the sacroiliac joints has limited diagnostic utility in nonradiographic axial spondyloarthritis. J Rheumatol. 2014;41:75–83. Study on the diagnostic utility of fat lesions in the sacroiliac joints.CrossRefPubMed

18.••

Weber U, Zubler V, Pedersen SJ, Rufibach K, Lambert RG, Chan SM, et al. Development and validation of a magnetic resonance imaging reference criterion for defining a positive sacroiliac joint magnetic resonance imaging finding in spondyloarthritis. Arthritis Care Res. 2013;65:977–85. Describes a data driven development of MRI criteria for axial SpA.CrossRef

19.

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20.

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21.••

Hermann KG, Baraliakos X, van der Heijde DM, Jurik AG, Landewe R, Marzo-Ortega H, et al. Descriptions of spinal MRI lesions and definition of a positive MRI of the spine in axial spondyloarthritis: a consensual approach by the ASAS/OMERACT MRI study group. Ann Rheum Dis. 2012;71:1278–88. The paper from ASAS about the definition of a positive MRI of the spine.CrossRefPubMed

22.•

Aydin SZ, Maksymowych WP, Bennett AN, McGonagle D, Emery P, Marzo-Ortega H. Validation of the ASAS criteria and definition of a positive MRI of the sacroiliac joint in an inception cohort of axial spondyloarthritis followed up for 8 years. Ann Rheum Dis. 2012;71:56–60. Investigates the prognostic value of the ASAS criteria for a positive MRI of the sacroiliac joints.CrossRefPubMed

23.

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24.

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25.•

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Maksymowych WP, Wichuk S, Chiowchanwisawakit P, Lambert RG, Pedersen SJ. Fat metaplasia and backfill are key intermediaries in the development of sacroiliac joint ankylosis in patients with ankylosing spondylitis. Arthritis Rheumatol. 2014;66:2958–67. Investigates the association between MRI lesions in the sacroiliac joints over 2 years.CrossRefPubMed

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Maksymowych WP, Morency N, Conner-Spady B, Lambert RG. Suppression of inflammation and effects on new bone formation in ankylosing spondylitis: evidence for a window of opportunity in disease modification. Ann Rheum Dis. 2013;72:23–8.CrossRefPubMed

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Pedersen SJ, Chiowchanwisawakit P, Lambert RG, Ostergaard M, Maksymowych WP. Resolution of inflammation following treatment of ankylosing spondylitis is associated with new bone formation. J Rheumatol. 2011;38:1349–54.CrossRefPubMed

38.••

Ramiro S, van Tubergen A, Van Der Heijde D, Stolwijk C, Bookelman G, Dougados M, et al. Brief report: erosions and sclerosis on radiographs precede the subsequent development of syndesmophytes at the same site: a twelve-year prospective followup of patients with ankylosing spondylitis. Arthritis Rheumatol. 2014;66:2773–9. Investigates the association between spinal lesions on conventional radiography and progression of radiographic damage.CrossRefPubMed

39.••

Ramiro S, Stolwijk C, van Tubergen A, Van Der Heijde D, Dougados M, Van Den Bosch F, et al. Evolution of radiographic damage in ankylosing spondylitis: a 12 year prospective follow-up of the OASIS study. Ann Rheum Dis. 2015;74:52–9. Describes radiographic progression and investigates its association with several clinical variables.CrossRefPubMed

40.••

Ramiro S, Van Der Heijde D, van Tubergen A, Stolwijk C, Dougados M, Van Den Bosch F, et al. Higher disease activity leads to more structural damage in the spine in ankylosing spondylitis: 12-year longitudinal data from the OASIS cohort. Ann Rheum Dis. 2014;73:1455–61. Investigates the association between structural progression on radiography and disease activity.CrossRefPubMed

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Bennett AN, Rehman A, Hensor EM, Marzo-Ortega H, Emery P, McGonagle D. Evaluation of the diagnostic utility of spinal magnetic resonance imaging in axial spondylarthritis. Arthritis Rheum. 2009;60:1331–41. Study on the diagnostic utility of bone marrow edema in the spine for diagnosing axial SpA.CrossRefPubMed

Titel: Recent Advances in Imaging of the Axial Skeleton in Spondyloarthritis for Diagnosis, Assessment of Treatment Effect, and Prognostication
verfasst von: Susanne Juhl Pedersen
Walter P. Maksymowych
Publikationsdatum: 01.09.2015
Verlag: Springer US
Erschienen in: Current Rheumatology Reports / Ausgabe 9/2015
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI: https://doi.org/10.1007/s11926-015-0531-2

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