Skip to main content

05.03.2024 | Review

Recent Progress in Myocardial Perfusion Imaging Techniques

verfasst von: Kwan Hyeong Jo, Won Jun Kang

Erschienen in: Nuclear Medicine and Molecular Imaging

Einloggen, um Zugang zu erhalten

Abstract

Nuclear cardiology, similar to other fields of nuclear medicine, has experience rapid advancements. Myocardial perfusion imaging (MPI), an important component of nuclear cardiology that commenced in the 1970s, plays a crucial role in the non-invasive evaluation and management of coronary artery disease. Over the past decade, MPI has witnessed significant changes and advancements. The introduction of gamma cameras using cadmium zinc telluride (CZT) systems, accompanied by advancements in related software, represents a notable development in this nuclear cardiology. Ongoing research and development effects are actively exploring new radiopharmaceuticals, with a particular focus on their application in positron emission tomography (PET)-MPI. Furthermore, studies have been conducted highlighting the necessity and benefits of hybrid imaging. However, as with other cutting-edge technologies, the practical application of the latest equipment and techniques in nuclear cardiology faces challenges stemming from their high costs of equipment and examinations and limited accessibility, which continue to remain significant barriers in nuclear medicine.
Literatur
1.
Zurück zum Zitat Zaret BL, Strauss HW, Martin ND, Wells HP, Flamm MD. Noninvasive regional myocardial perfusion with radioactive potassium. Study of patients at rest, with exercise and during angina pectoris. N Engl J Med. 1973;288:809-12. Zaret BL, Strauss HW, Martin ND, Wells HP, Flamm MD. Noninvasive regional myocardial perfusion with radioactive potassium. Study of patients at rest, with exercise and during angina pectoris. N Engl J Med. 1973;288:809-12.
2.
Zurück zum Zitat Rozanski A, Gransar H, Hayes SW, Min J, Friedman JD, Thomson LE, et al. Temporal trends in the frequency of inducible myocardial ischemia during cardiac stress testing: 1991 to 2009. J Am Coll Cardiol. 2013;61:1054–65.CrossRefPubMed Rozanski A, Gransar H, Hayes SW, Min J, Friedman JD, Thomson LE, et al. Temporal trends in the frequency of inducible myocardial ischemia during cardiac stress testing: 1991 to 2009. J Am Coll Cardiol. 2013;61:1054–65.CrossRefPubMed
3.
Zurück zum Zitat Hendel RC, Berman DS, Di Carli MF, Heidenreich PA, Henkin RE, Pellikka PA, et al. ACCF/ASNC/ACR/AHA/ASE/SCCT/SCMR/SNM 2009 appropriate use criteria for cardiac radionuclide imaging: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the American Society of Nuclear Cardiology, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the Society of Cardiovascular Computed Tomography, the Society for Cardiovascular Magnetic Resonance, and the Society of Nuclear Medicine. Circulation. 2009;119:e561-87.PubMed Hendel RC, Berman DS, Di Carli MF, Heidenreich PA, Henkin RE, Pellikka PA, et al. ACCF/ASNC/ACR/AHA/ASE/SCCT/SCMR/SNM 2009 appropriate use criteria for cardiac radionuclide imaging: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the American Society of Nuclear Cardiology, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the Society of Cardiovascular Computed Tomography, the Society for Cardiovascular Magnetic Resonance, and the Society of Nuclear Medicine. Circulation. 2009;119:e561-87.PubMed
5.
Zurück zum Zitat Patton JA, Slomka PJ, Germano G, Berman DS. Recent technologic advances in nuclear cardiology. J Nucl Cardiol. 2007;14:501–13.CrossRefPubMed Patton JA, Slomka PJ, Germano G, Berman DS. Recent technologic advances in nuclear cardiology. J Nucl Cardiol. 2007;14:501–13.CrossRefPubMed
6.
Zurück zum Zitat Dorbala S, Ananthasubramaniam K, Armstrong IS, Chareonthaitawee P, DePuey EG, Einstein AJ, et al. Single photon emission computed tomography (SPECT) myocardial perfusion imaging guidelines: instrumentation, acquisition, processing, and interpretation. J Nucl Cardiol. 2018;25:1784–846.CrossRefPubMed Dorbala S, Ananthasubramaniam K, Armstrong IS, Chareonthaitawee P, DePuey EG, Einstein AJ, et al. Single photon emission computed tomography (SPECT) myocardial perfusion imaging guidelines: instrumentation, acquisition, processing, and interpretation. J Nucl Cardiol. 2018;25:1784–846.CrossRefPubMed
7.
Zurück zum Zitat Erlandsson K, Kacperski K, van Gramberg D, Hutton BF. Performance evaluation of D-SPECT: a novel SPECT system for nuclear cardiology. Phys Med Biol. 2009;54:2635–49.CrossRefPubMed Erlandsson K, Kacperski K, van Gramberg D, Hutton BF. Performance evaluation of D-SPECT: a novel SPECT system for nuclear cardiology. Phys Med Biol. 2009;54:2635–49.CrossRefPubMed
8.
Zurück zum Zitat Gambhir SS, Berman DS, Ziffer J, Nagler M, Sandler M, Patton J, et al. A novel high-sensitivity rapid-acquisition single-photon cardiac imaging camera. J Nucl Med. 2009;50:635–43.CrossRefPubMed Gambhir SS, Berman DS, Ziffer J, Nagler M, Sandler M, Patton J, et al. A novel high-sensitivity rapid-acquisition single-photon cardiac imaging camera. J Nucl Med. 2009;50:635–43.CrossRefPubMed
9.
Zurück zum Zitat Sharir T, Slomka PJ, Hayes SW, DiCarli MF, Ziffer JA, Martin WH, et al. Multicenter trial of high-speed versus conventional single-photon emission computed tomography imaging: quantitative results of myocardial perfusion and left ventricular function. J Am Coll Cardiol. 2010;55:1965–74.CrossRefPubMed Sharir T, Slomka PJ, Hayes SW, DiCarli MF, Ziffer JA, Martin WH, et al. Multicenter trial of high-speed versus conventional single-photon emission computed tomography imaging: quantitative results of myocardial perfusion and left ventricular function. J Am Coll Cardiol. 2010;55:1965–74.CrossRefPubMed
10.
Zurück zum Zitat Nakazato R, Tamarappoo BK, Kang X, Wolak A, Kite F, Hayes SW, et al. Quantitative upright-supine high-speed SPECT myocardial perfusion imaging for detection of coronary artery disease: correlation with invasive coronary angiography. J Nucl Med. 2010;51:1724–31.CrossRefPubMed Nakazato R, Tamarappoo BK, Kang X, Wolak A, Kite F, Hayes SW, et al. Quantitative upright-supine high-speed SPECT myocardial perfusion imaging for detection of coronary artery disease: correlation with invasive coronary angiography. J Nucl Med. 2010;51:1724–31.CrossRefPubMed
11.
Zurück zum Zitat Duvall WL, Slomka PJ, Gerlach JR, Sweeny JM, Baber U, Croft LB, et al. High-efficiency SPECT MPI: comparison of automated quantification, visual interpretation, and coronary angiography. J Nucl Cardiol. 2013;20:763–73.CrossRefPubMed Duvall WL, Slomka PJ, Gerlach JR, Sweeny JM, Baber U, Croft LB, et al. High-efficiency SPECT MPI: comparison of automated quantification, visual interpretation, and coronary angiography. J Nucl Cardiol. 2013;20:763–73.CrossRefPubMed
12.
Zurück zum Zitat Nishiyama Y, Miyagawa M, Kawaguchi N, Nakamura M, Kido T, Kurata A, et al. Combined supine and prone myocardial perfusion single-photon emission computed tomography with a cadmium zinc telluride camera for detection of coronary artery disease. Circ J. 2014;78:1169–75.CrossRefPubMed Nishiyama Y, Miyagawa M, Kawaguchi N, Nakamura M, Kido T, Kurata A, et al. Combined supine and prone myocardial perfusion single-photon emission computed tomography with a cadmium zinc telluride camera for detection of coronary artery disease. Circ J. 2014;78:1169–75.CrossRefPubMed
13.
Zurück zum Zitat Duvall WL, Croft LB, Ginsberg ES, Einstein AJ, Guma KA, George T, et al. Reduced isotope dose and imaging time with a high-efficiency CZT SPECT camera. J Nucl Cardiol. 2011;18:847–57.CrossRefPubMed Duvall WL, Croft LB, Ginsberg ES, Einstein AJ, Guma KA, George T, et al. Reduced isotope dose and imaging time with a high-efficiency CZT SPECT camera. J Nucl Cardiol. 2011;18:847–57.CrossRefPubMed
14.
Zurück zum Zitat Duvall WL, Sweeny JM, Croft LB, Ginsberg E, Guma KA, Henzlova MJ. Reduced stress dose with rapid acquisition CZT SPECT MPI in a non-obese clinical population: comparison to coronary angiography. J Nucl Cardiol. 2012;19:19–27.CrossRefPubMed Duvall WL, Sweeny JM, Croft LB, Ginsberg E, Guma KA, Henzlova MJ. Reduced stress dose with rapid acquisition CZT SPECT MPI in a non-obese clinical population: comparison to coronary angiography. J Nucl Cardiol. 2012;19:19–27.CrossRefPubMed
15.
Zurück zum Zitat Tissot H, Roch V, Morel O, Veran N, Perrin M, Claudin M, et al. Left ventricular ejection fraction determined with the simulation of a very low-dose CZT-SPECT protocol and an additional count-calibration on planar radionuclide angiographic data. J Nucl Cardiol. 2019;26:1539–49.CrossRefPubMed Tissot H, Roch V, Morel O, Veran N, Perrin M, Claudin M, et al. Left ventricular ejection fraction determined with the simulation of a very low-dose CZT-SPECT protocol and an additional count-calibration on planar radionuclide angiographic data. J Nucl Cardiol. 2019;26:1539–49.CrossRefPubMed
16.
Zurück zum Zitat Johnson RD, Bath NK, Rinker J, Fong S, St James S, Pampaloni MH, et al. Introduction to the D-SPECT for technologists: workflow using a dedicated digital cardiac camera. J Nucl Med Technol. 2020;48:297–303.CrossRefPubMed Johnson RD, Bath NK, Rinker J, Fong S, St James S, Pampaloni MH, et al. Introduction to the D-SPECT for technologists: workflow using a dedicated digital cardiac camera. J Nucl Med Technol. 2020;48:297–303.CrossRefPubMed
17.
Zurück zum Zitat Sharir T, Ben-Haim S, Merzon K, Prochorov V, Dickman D, Ben-Haim S, et al. High-speed myocardial perfusion imaging initial clinical comparison with conventional dual detector anger camera imaging. JACC Cardiovasc Imaging. 2008;1:156–63.CrossRefPubMed Sharir T, Ben-Haim S, Merzon K, Prochorov V, Dickman D, Ben-Haim S, et al. High-speed myocardial perfusion imaging initial clinical comparison with conventional dual detector anger camera imaging. JACC Cardiovasc Imaging. 2008;1:156–63.CrossRefPubMed
18.
Zurück zum Zitat Imbert L, Poussier S, Franken PR, Songy B, Verger A, Morel O, et al. Compared performance of high-sensitivity cameras dedicated to myocardial perfusion SPECT: a comprehensive analysis of phantom and human images. J Nucl Med. 2012;53:1897–903.CrossRefPubMed Imbert L, Poussier S, Franken PR, Songy B, Verger A, Morel O, et al. Compared performance of high-sensitivity cameras dedicated to myocardial perfusion SPECT: a comprehensive analysis of phantom and human images. J Nucl Med. 2012;53:1897–903.CrossRefPubMed
19.
Zurück zum Zitat Miyagawa M, Nishiyama Y, Uetani T, Ogimoto A, Ikeda S, Ishimura H, et al. Estimation of myocardial flow reserve utilizing an ultrafast cardiac SPECT: comparison with coronary angiography, fractional flow reserve, and the SYNTAX score. Int J Cardiol. 2017;244:347–53.CrossRefPubMed Miyagawa M, Nishiyama Y, Uetani T, Ogimoto A, Ikeda S, Ishimura H, et al. Estimation of myocardial flow reserve utilizing an ultrafast cardiac SPECT: comparison with coronary angiography, fractional flow reserve, and the SYNTAX score. Int J Cardiol. 2017;244:347–53.CrossRefPubMed
20.
Zurück zum Zitat Wells RG, Marvin B, Poirier M, Renaud J, deKemp RA, Ruddy TD. Optimization of SPECT measurement of myocardial blood flow with corrections for attenuation, motion, and blood binding compared with PET. J Nucl Med. 2017;58:2013–9.CrossRefPubMed Wells RG, Marvin B, Poirier M, Renaud J, deKemp RA, Ruddy TD. Optimization of SPECT measurement of myocardial blood flow with corrections for attenuation, motion, and blood binding compared with PET. J Nucl Med. 2017;58:2013–9.CrossRefPubMed
21.
Zurück zum Zitat Agostini D, Roule V, Nganoa C, Roth N, Baavour R, Parienti JJ, et al. First validation of myocardial flow reserve assessed by dynamic (99m)Tc-sestamibi CZT-SPECT camera: head to head comparison with (15)O-water PET and fractional flow reserve in patients with suspected coronary artery disease. The WATERDAY study. Eur J Nucl Med Mol Imaging. 2018;45:1079-90. Agostini D, Roule V, Nganoa C, Roth N, Baavour R, Parienti JJ, et al. First validation of myocardial flow reserve assessed by dynamic (99m)Tc-sestamibi CZT-SPECT camera: head to head comparison with (15)O-water PET and fractional flow reserve in patients with suspected coronary artery disease. The WATERDAY study. Eur J Nucl Med Mol Imaging. 2018;45:1079-90.
22.
Zurück zum Zitat Zavadovsky KV, Mochula AV, Boshchenko AA, Vrublevsky AV, Baev AE, Krylov AL, et al. Absolute myocardial blood flows derived by dynamic CZT scan vs invasive fractional flow reserve: correlation and accuracy. J Nucl Cardiol. 2021;28:249–59.CrossRefPubMed Zavadovsky KV, Mochula AV, Boshchenko AA, Vrublevsky AV, Baev AE, Krylov AL, et al. Absolute myocardial blood flows derived by dynamic CZT scan vs invasive fractional flow reserve: correlation and accuracy. J Nucl Cardiol. 2021;28:249–59.CrossRefPubMed
23.
Zurück zum Zitat de Souza ACDAH, Gonçalves BKD, Tedeschi AL, Lima RSL. Quantification of myocardial flow reserve using a gamma camera with solid-state cadmium-zinc-telluride detectors: relation to angiographic coronary artery disease. J Nucl Cardiol. 2021;28:876-84. de Souza ACDAH, Gonçalves BKD, Tedeschi AL, Lima RSL. Quantification of myocardial flow reserve using a gamma camera with solid-state cadmium-zinc-telluride detectors: relation to angiographic coronary artery disease. J Nucl Cardiol. 2021;28:876-84.
24.
Zurück zum Zitat Koenders SS, van Dalen JA, Jager PL, Knollema S, Timmer JR, Mouden M, et al. Value of SiPM PET in myocardial perfusion imaging using rubidium-82. J Nucl Cardiol. 2022;29:204–12.CrossRefPubMed Koenders SS, van Dalen JA, Jager PL, Knollema S, Timmer JR, Mouden M, et al. Value of SiPM PET in myocardial perfusion imaging using rubidium-82. J Nucl Cardiol. 2022;29:204–12.CrossRefPubMed
25.
Zurück zum Zitat Alahdab F, Al Rifai M, Ahmed AI, Al-Mallah MH. Advances in digital PET technology and its potential impact on myocardial perfusion and blood flow quantification. Curr Cardiol Rep. 2023;25:261–8.CrossRefPubMed Alahdab F, Al Rifai M, Ahmed AI, Al-Mallah MH. Advances in digital PET technology and its potential impact on myocardial perfusion and blood flow quantification. Curr Cardiol Rep. 2023;25:261–8.CrossRefPubMed
26.
Zurück zum Zitat Dietz M, Kamani CH, Allenbach G, Rubimbura V, Fournier S, Dunet V, et al. Comparison of the prognostic value of impaired stress myocardial blood flow, myocardial flow reserve, and myocardial flow capacity on low-dose Rubidium-82 SiPM PET/CT. J Nucl Cardiol. 2023;30:1385–95.CrossRefPubMed Dietz M, Kamani CH, Allenbach G, Rubimbura V, Fournier S, Dunet V, et al. Comparison of the prognostic value of impaired stress myocardial blood flow, myocardial flow reserve, and myocardial flow capacity on low-dose Rubidium-82 SiPM PET/CT. J Nucl Cardiol. 2023;30:1385–95.CrossRefPubMed
27.
Zurück zum Zitat van Dijk JD, Jager PL, van Osch JAC, Khodaverdi M, van Dalen JA. Comparison of maximal rubidium-82 activities for myocardial blood flow quantification between digital and conventional PET systems. J Nucl Cardiol. 2019;26:1286–91.CrossRefPubMed van Dijk JD, Jager PL, van Osch JAC, Khodaverdi M, van Dalen JA. Comparison of maximal rubidium-82 activities for myocardial blood flow quantification between digital and conventional PET systems. J Nucl Cardiol. 2019;26:1286–91.CrossRefPubMed
28.
Zurück zum Zitat Sciagrà R, Lubberink M, Hyafil F, Saraste A, Slart RHJA, Agostini D, et al. EANM procedural guidelines for PET/CT quantitative myocardial perfusion imaging. Eur J Nucl Med Mol Imaging. 2021;48:1040–69.CrossRefPubMed Sciagrà R, Lubberink M, Hyafil F, Saraste A, Slart RHJA, Agostini D, et al. EANM procedural guidelines for PET/CT quantitative myocardial perfusion imaging. Eur J Nucl Med Mol Imaging. 2021;48:1040–69.CrossRefPubMed
29.
Zurück zum Zitat Slart RHJA, Tsoumpas C, Glaudemans AWJM, Noordzij W, Willemsen ATM, Borra RJH, et al. Long axial field of view PET scanners: a road map to implementation and new possibilities. Eur J Nucl Med Mol Imaging. 2021;48:4236–45.CrossRefPubMedPubMedCentral Slart RHJA, Tsoumpas C, Glaudemans AWJM, Noordzij W, Willemsen ATM, Borra RJH, et al. Long axial field of view PET scanners: a road map to implementation and new possibilities. Eur J Nucl Med Mol Imaging. 2021;48:4236–45.CrossRefPubMedPubMedCentral
30.
Zurück zum Zitat Alberts I, Sari H, Mingels C, Afshar-Oromieh A, Pyka T, Shi K, et al. Long-axial field-of-view PET/CT: perspectives and review of a revolutionary development in nuclear medicine based on clinical experience in over 7000 patients. Cancer Imaging. 2023;23:28.CrossRefPubMedPubMedCentral Alberts I, Sari H, Mingels C, Afshar-Oromieh A, Pyka T, Shi K, et al. Long-axial field-of-view PET/CT: perspectives and review of a revolutionary development in nuclear medicine based on clinical experience in over 7000 patients. Cancer Imaging. 2023;23:28.CrossRefPubMedPubMedCentral
32.
Zurück zum Zitat Kiat H, Germano G, Friedman J, Van Train K, Silagan G, Wang FP, et al. Comparative feasibility of separate or simultaneous rest thallium-201/stress technetium-99m-sestamibi dual-isotope myocardial perfusion SPECT. J Nucl Med. 1994;35:542–8.PubMed Kiat H, Germano G, Friedman J, Van Train K, Silagan G, Wang FP, et al. Comparative feasibility of separate or simultaneous rest thallium-201/stress technetium-99m-sestamibi dual-isotope myocardial perfusion SPECT. J Nucl Med. 1994;35:542–8.PubMed
33.
Zurück zum Zitat Berman DS, Kang X, Tamarappoo B, Wolak A, Hayes SW, Nakazato R, et al. Stress thallium-201/rest technetium-99m sequential dual isotope high-speed myocardial perfusion imaging. JACC Cardiovasc Imaging. 2009;2:273–82.CrossRefPubMed Berman DS, Kang X, Tamarappoo B, Wolak A, Hayes SW, Nakazato R, et al. Stress thallium-201/rest technetium-99m sequential dual isotope high-speed myocardial perfusion imaging. JACC Cardiovasc Imaging. 2009;2:273–82.CrossRefPubMed
34.
Zurück zum Zitat Barone-Rochette G, Leclere M, Calizzano A, Vautrin E, Céline GC, Broisat A, et al. Stress thallium-201/rest technetium-99m sequential dual-isotope high-speed myocardial perfusion imaging validation versus invasive coronary angiography. J Nucl Cardiol. 2015;22:513–22.CrossRefPubMed Barone-Rochette G, Leclere M, Calizzano A, Vautrin E, Céline GC, Broisat A, et al. Stress thallium-201/rest technetium-99m sequential dual-isotope high-speed myocardial perfusion imaging validation versus invasive coronary angiography. J Nucl Cardiol. 2015;22:513–22.CrossRefPubMed
35.
Zurück zum Zitat Mc Ardle BA, Dowsley TF, deKemp RA, Wells GA, Beanlands RS. Does rubidium-82 PET have superior accuracy to SPECT perfusion imaging for the diagnosis of obstructive coronary disease?: a systematic review and meta-analysis. J Am Coll Cardiol. 2012;60:1828–37.CrossRefPubMed Mc Ardle BA, Dowsley TF, deKemp RA, Wells GA, Beanlands RS. Does rubidium-82 PET have superior accuracy to SPECT perfusion imaging for the diagnosis of obstructive coronary disease?: a systematic review and meta-analysis. J Am Coll Cardiol. 2012;60:1828–37.CrossRefPubMed
36.
Zurück zum Zitat Takx RA, Blomberg BA, El Aidi H, Habets J, de Jong PA, Nagel E, et al. Diagnostic accuracy of stress myocardial perfusion imaging compared to invasive coronary angiography with fractional flow reserve meta-analysis. Circ Cardiovasc Imaging. 2015;8. Takx RA, Blomberg BA, El Aidi H, Habets J, de Jong PA, Nagel E, et al. Diagnostic accuracy of stress myocardial perfusion imaging compared to invasive coronary angiography with fractional flow reserve meta-analysis. Circ Cardiovasc Imaging. 2015;8.
37.
Zurück zum Zitat Danad I, Raijmakers PG, Driessen RS, Leipsic J, Raju R, Naoum C, et al. Comparison of coronary CT angiography, SPECT, PET, and hybrid imaging for diagnosis of ischemic heart disease determined by fractional flow reserve. JAMA Cardiol. 2017;2:1100–7.CrossRefPubMedPubMedCentral Danad I, Raijmakers PG, Driessen RS, Leipsic J, Raju R, Naoum C, et al. Comparison of coronary CT angiography, SPECT, PET, and hybrid imaging for diagnosis of ischemic heart disease determined by fractional flow reserve. JAMA Cardiol. 2017;2:1100–7.CrossRefPubMedPubMedCentral
38.
Zurück zum Zitat Driessen RS, Danad I, Stuijfzand WJ, Raijmakers PG, Schumacher SP, van Diemen PA, et al. Comparison of coronary computed tomography angiography, fractional flow reserve, and perfusion imaging for ischemia diagnosis. J Am Coll Cardiol. 2019;73:161–73.CrossRefPubMed Driessen RS, Danad I, Stuijfzand WJ, Raijmakers PG, Schumacher SP, van Diemen PA, et al. Comparison of coronary computed tomography angiography, fractional flow reserve, and perfusion imaging for ischemia diagnosis. J Am Coll Cardiol. 2019;73:161–73.CrossRefPubMed
39.
Zurück zum Zitat Di Carli MF. PET perfusion and flow assessment: tomorrows’ technology today. Semin Nucl Med. 2020;50:227–37.CrossRefPubMed Di Carli MF. PET perfusion and flow assessment: tomorrows’ technology today. Semin Nucl Med. 2020;50:227–37.CrossRefPubMed
40.
Zurück zum Zitat Werner RA, Chen X, Rowe SP, Lapa C, Javadi MS, Higuchi T. Moving into the next era of PET myocardial perfusion imaging: introduction of novel (18)F-labeled tracers. Int J Cardiovasc Imaging. 2019;35:569–77.CrossRefPubMed Werner RA, Chen X, Rowe SP, Lapa C, Javadi MS, Higuchi T. Moving into the next era of PET myocardial perfusion imaging: introduction of novel (18)F-labeled tracers. Int J Cardiovasc Imaging. 2019;35:569–77.CrossRefPubMed
42.
Zurück zum Zitat Singh SB, Ng SJ, Lau HC, Khanal K, Bhattarai S, Paudyal P, et al. Emerging PET tracers in cardiac molecular imaging. Cardiol Ther. 2023;12:85–99.CrossRefPubMedPubMedCentral Singh SB, Ng SJ, Lau HC, Khanal K, Bhattarai S, Paudyal P, et al. Emerging PET tracers in cardiac molecular imaging. Cardiol Ther. 2023;12:85–99.CrossRefPubMedPubMedCentral
43.
Zurück zum Zitat Yu M, Nekolla SG, Schwaiger M, Robinson SP. The next generation of cardiac positron emission tomography imaging agents: discovery of flurpiridaz F-18 for detection of coronary disease. Semin Nucl Med. 2011;41:305–13.CrossRefPubMed Yu M, Nekolla SG, Schwaiger M, Robinson SP. The next generation of cardiac positron emission tomography imaging agents: discovery of flurpiridaz F-18 for detection of coronary disease. Semin Nucl Med. 2011;41:305–13.CrossRefPubMed
44.
Zurück zum Zitat Sherif HM, Nekolla SG, Saraste A, Reder S, Yu M, Robinson S, et al. Simplified quantification of myocardial flow reserve with flurpiridaz F 18: validation with microspheres in a pig model. J Nucl Med. 2011;52:617–24.CrossRefPubMed Sherif HM, Nekolla SG, Saraste A, Reder S, Yu M, Robinson S, et al. Simplified quantification of myocardial flow reserve with flurpiridaz F 18: validation with microspheres in a pig model. J Nucl Med. 2011;52:617–24.CrossRefPubMed
45.
Zurück zum Zitat Huisman MC, Higuchi T, Reder S, Nekolla SG, Poethko T, Wester HJ, et al. Initial characterization of an 18F-labeled myocardial perfusion tracer. J Nucl Med. 2008;49:630–6.CrossRefPubMed Huisman MC, Higuchi T, Reder S, Nekolla SG, Poethko T, Wester HJ, et al. Initial characterization of an 18F-labeled myocardial perfusion tracer. J Nucl Med. 2008;49:630–6.CrossRefPubMed
46.
Zurück zum Zitat Calnon DA. Will (18)F flurpiridaz replace (82)rubidium as the most commonly used perfusion tracer for PET myocardial perfusion imaging? J Nucl Cardiol. 2019;26:2031–3.CrossRefPubMed Calnon DA. Will (18)F flurpiridaz replace (82)rubidium as the most commonly used perfusion tracer for PET myocardial perfusion imaging? J Nucl Cardiol. 2019;26:2031–3.CrossRefPubMed
47.
Zurück zum Zitat Moody JB, Poitrasson-Rivière A, Hagio T, Buckley C, Weinberg RL, Corbett JR, et al. Added value of myocardial blood flow using (18)F-flurpiridaz PET to diagnose coronary artery disease: the flurpiridaz 301 trial. J Nucl Cardiol. 2021;28:2313–29.CrossRefPubMed Moody JB, Poitrasson-Rivière A, Hagio T, Buckley C, Weinberg RL, Corbett JR, et al. Added value of myocardial blood flow using (18)F-flurpiridaz PET to diagnose coronary artery disease: the flurpiridaz 301 trial. J Nucl Cardiol. 2021;28:2313–29.CrossRefPubMed
48.
Zurück zum Zitat Maddahi J, Lazewatsky J, Udelson JE, Berman DS, Beanlands RSB, Heller GV, et al. Phase-III clinical trial of fluorine-18 flurpiridaz positron emission tomography for evaluation of coronary artery disease. J Am Coll Cardiol. 2020;76:391–401.CrossRefPubMed Maddahi J, Lazewatsky J, Udelson JE, Berman DS, Beanlands RSB, Heller GV, et al. Phase-III clinical trial of fluorine-18 flurpiridaz positron emission tomography for evaluation of coronary artery disease. J Am Coll Cardiol. 2020;76:391–401.CrossRefPubMed
49.
Zurück zum Zitat Packard RRS, Lazewatsky JL, Orlandi C, Maddahi J. Diagnostic performance of PET versus SPECT myocardial perfusion imaging in patients with smaller left ventricles: a substudy of the (18)F-flurpiridaz phase III clinical trial. J Nucl Med. 2021;62:849–54.CrossRefPubMedPubMedCentral Packard RRS, Lazewatsky JL, Orlandi C, Maddahi J. Diagnostic performance of PET versus SPECT myocardial perfusion imaging in patients with smaller left ventricles: a substudy of the (18)F-flurpiridaz phase III clinical trial. J Nucl Med. 2021;62:849–54.CrossRefPubMedPubMedCentral
50.
Zurück zum Zitat Gaemperli O, Kaufmann PA, Alkadhi H. Cardiac hybrid imaging. Eur J Nucl Med Mol Imaging. 2014;41(Suppl 1):S91-103.CrossRefPubMed Gaemperli O, Kaufmann PA, Alkadhi H. Cardiac hybrid imaging. Eur J Nucl Med Mol Imaging. 2014;41(Suppl 1):S91-103.CrossRefPubMed
51.
Zurück zum Zitat Gaemperli O, Saraste A, Knuuti J. Cardiac hybrid imaging. Eur Heart J Cardiovasc Imaging. 2012;13(1):51–60.CrossRefPubMed Gaemperli O, Saraste A, Knuuti J. Cardiac hybrid imaging. Eur Heart J Cardiovasc Imaging. 2012;13(1):51–60.CrossRefPubMed
52.
Zurück zum Zitat Nieman K, Balla S. Dynamic CT myocardial perfusion imaging. J Cardiovasc Comput Tomogr. 2020;14(4):303–6.CrossRefPubMed Nieman K, Balla S. Dynamic CT myocardial perfusion imaging. J Cardiovasc Comput Tomogr. 2020;14(4):303–6.CrossRefPubMed
53.
Zurück zum Zitat Qayyum AA, Kastrup J. Measuring myocardial perfusion: the role of PET. MRI and CT Clin Radiol. 2015;70(6):576–84.CrossRefPubMed Qayyum AA, Kastrup J. Measuring myocardial perfusion: the role of PET. MRI and CT Clin Radiol. 2015;70(6):576–84.CrossRefPubMed
54.
Zurück zum Zitat Rizvi A, Han D, Danad I, Ó Hartaigh B, Lee JH, Gransar H, et al. Diagnostic performance of hybrid cardiac imaging methods for assessment of obstructive coronary artery disease compared with stand-alone coronary computed tomography angiography: a meta-analysis. JACC Cardiovasc Imaging. 2018;11:589-99. Rizvi A, Han D, Danad I, Ó Hartaigh B, Lee JH, Gransar H, et al. Diagnostic performance of hybrid cardiac imaging methods for assessment of obstructive coronary artery disease compared with stand-alone coronary computed tomography angiography: a meta-analysis. JACC Cardiovasc Imaging. 2018;11:589-99.
55.
Zurück zum Zitat Javadi MS, Lautamäki R, Merrill J, Voicu C, Epley W, McBride G, et al. Definition of vascular territories on myocardial perfusion images by integration with true coronary anatomy: a hybrid PET/CT analysis. J Nucl Med. 2010;51:198–203.CrossRefPubMed Javadi MS, Lautamäki R, Merrill J, Voicu C, Epley W, McBride G, et al. Definition of vascular territories on myocardial perfusion images by integration with true coronary anatomy: a hybrid PET/CT analysis. J Nucl Med. 2010;51:198–203.CrossRefPubMed
56.
Zurück zum Zitat Rispler S, Keidar Z, Ghersin E, Roguin A, Soil A, Dragu R, et al. Integrated single-photon emission computed tomography and computed tomography coronary angiography for the assessment of hemodynamically significant coronary artery lesions. J Am Coll Cardiol. 2007;49:1059–67.CrossRefPubMed Rispler S, Keidar Z, Ghersin E, Roguin A, Soil A, Dragu R, et al. Integrated single-photon emission computed tomography and computed tomography coronary angiography for the assessment of hemodynamically significant coronary artery lesions. J Am Coll Cardiol. 2007;49:1059–67.CrossRefPubMed
57.
Zurück zum Zitat Pazhenkottil AP, Benz DC, Gräni C, Madsen MA, Mikulicic F, von Felten E, et al. Hybrid SPECT perfusion imaging and coronary CT angiography: long-term prognostic value for cardiovascular outcomes. Radiology. 2018;288:694–702.CrossRefPubMed Pazhenkottil AP, Benz DC, Gräni C, Madsen MA, Mikulicic F, von Felten E, et al. Hybrid SPECT perfusion imaging and coronary CT angiography: long-term prognostic value for cardiovascular outcomes. Radiology. 2018;288:694–702.CrossRefPubMed
58.
Zurück zum Zitat Liga R, Vontobel J, Rovai D, Marinelli M, Caselli C, Pietila M, et al. Multicentre multi-device hybrid imaging study of coronary artery disease: results from the Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischaemic Heart Disease (EVINCI) hybrid imaging population. Eur Heart J Cardiovasc Imaging. 2016;17:951–60.CrossRefPubMedPubMedCentral Liga R, Vontobel J, Rovai D, Marinelli M, Caselli C, Pietila M, et al. Multicentre multi-device hybrid imaging study of coronary artery disease: results from the Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischaemic Heart Disease (EVINCI) hybrid imaging population. Eur Heart J Cardiovasc Imaging. 2016;17:951–60.CrossRefPubMedPubMedCentral
Metadaten
Titel
Recent Progress in Myocardial Perfusion Imaging Techniques
verfasst von
Kwan Hyeong Jo
Won Jun Kang
Publikationsdatum
05.03.2024
Verlag
Springer Nature Singapore
Erschienen in
Nuclear Medicine and Molecular Imaging
Print ISSN: 1869-3474
Elektronische ISSN: 1869-3482
DOI
https://doi.org/10.1007/s13139-024-00852-7