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Erschienen in: Current Osteoporosis Reports 6/2016

04.10.2016 | Craniofacial Skeleton (G Roberts, Section Editor)

Recent Tissue Engineering Advances for the Treatment of Temporomandibular Joint Disorders

verfasst von: Ashkan Aryaei, Natalia Vapniarsky, Jerry C. Hu, Kyriacos A. Athanasiou

Erschienen in: Current Osteoporosis Reports | Ausgabe 6/2016

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Abstract

Temporomandibular disorders (TMDs) are among the most common maxillofacial complaints and a major cause of orofacial pain. Although current treatments provide short- and long-term relief, alternative tissue engineering solutions are in great demand. Particularly, the development of strategies, providing long-term resolution of TMD to help patients regain normal function, is a high priority. An absolute prerequisite of tissue engineering is to understand normal structure and function. The current knowledge of anatomical, mechanical, and biochemical characteristics of the temporomandibular joint (TMJ) and associated tissues will be discussed, followed by a brief description of current TMD treatments. The main focus is on recent tissue engineering developments for regenerating TMJ tissue components, with or without a scaffold. The expectation for effectively managing TMD is that tissue engineering will produce biomimetic TMJ tissues that recapitulate the normal structure and function of the TMJ.
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Zurück zum Zitat MacBarb RF, Makris EA, Hu JC, Athanasiou KA. A chondroitinase-ABC and TGF-β1 treatment regimen for enhancing the mechanical properties of tissue-engineered fibrocartilage. Acta Biomater. 2013;9:4626–34. Paper presents the effects of bioactive stimulation and cell ratio on mechanical properties improvement of tissue engineered fibrocartilage. It has been shown the application of both chondroitinase-ABC and TGF-β1 increased the collagen content of treated constructs compared to controls. PubMedCrossRef MacBarb RF, Makris EA, Hu JC, Athanasiou KA. A chondroitinase-ABC and TGF-β1 treatment regimen for enhancing the mechanical properties of tissue-engineered fibrocartilage. Acta Biomater. 2013;9:4626–34. Paper presents the effects of bioactive stimulation and cell ratio on mechanical properties improvement of tissue engineered fibrocartilage. It has been shown the application of both chondroitinase-ABC and TGF-β1 increased the collagen content of treated constructs compared to controls. PubMedCrossRef
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Zurück zum Zitat Makris EA, MacBarb RF, Paschos NK, Hu JC, Hu JC, Athanasiou KA. Combined use of chondroitinase-ABC, TGF-β1, and collagen crosslinking agent lysyl oxidase to engineer functional neotissues for fibrocartilage repair. Biogeosciences. 2014;35:6787–96. Paper demonstrates the combined usage of Chondroitinase-ABC, TGF-β1, and collagen crosslinking agent lysyl oxidase improves mechanical and biochemical properties at higher time points. Followed by in vivo study, authors showed robust integration between the engineered and native tissues using mechanical testing and histology. Makris EA, MacBarb RF, Paschos NK, Hu JC, Hu JC, Athanasiou KA. Combined use of chondroitinase-ABC, TGF-β1, and collagen crosslinking agent lysyl oxidase to engineer functional neotissues for fibrocartilage repair. Biogeosciences. 2014;35:6787–96. Paper demonstrates the combined usage of Chondroitinase-ABC, TGF-β1, and collagen crosslinking agent lysyl oxidase improves mechanical and biochemical properties at higher time points. Followed by in vivo study, authors showed robust integration between the engineered and native tissues using mechanical testing and histology.
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Zurück zum Zitat Sheehy EJ, Mesallati T, Kelly L, Vinardell T, Buckley CT, Kelly DJ. Tissue engineering whole bones through endochondral ossification: regenerating the distal phalanx. Biores Open Access. 2015;4:229–41.PubMedPubMedCentralCrossRef Sheehy EJ, Mesallati T, Kelly L, Vinardell T, Buckley CT, Kelly DJ. Tissue engineering whole bones through endochondral ossification: regenerating the distal phalanx. Biores Open Access. 2015;4:229–41.PubMedPubMedCentralCrossRef
Metadaten
Titel
Recent Tissue Engineering Advances for the Treatment of Temporomandibular Joint Disorders
verfasst von
Ashkan Aryaei
Natalia Vapniarsky
Jerry C. Hu
Kyriacos A. Athanasiou
Publikationsdatum
04.10.2016
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 6/2016
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-016-0327-y

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