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Erschienen in:
14.10.2021 | Original Article
Recipient IL28B genotype CT is a predictor of new onset diabetes mellitus in liver transplant patients with chronic hepatitis C
Erschienen in: International Journal of Diabetes in Developing Countries | Ausgabe 4/2022
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Background
New onset diabetes after liver transplantation (NODAT) is increasingly recognized as a complication that affects the quality of life. In addition to well-known risk factors for diabetes in such patients, little is known regarding the genetic predisposition for this condition.
Aims
To study the association of IL28B polymorphism with occurrence of new onset diabetes after liver transplantation in HCV patients.
Methods
A prospective cohort study. Fifty non-diabetic LDLT recipients were recruited from the Liver Transplantation Unit at El Manial, Cairo University Hospital. FBS was done at 0, 3, and 12 months; HBA1c was done after 6 months. IL28B rs12979860 polymorphism was done to all patients.
Results
According to FBS after 3 months and HBA1C, 20 patients developed diabetes, 21 patients prediabetes and 9 remained normal. IL28B CT genotype was 78%, CC 20% and TT 2%. Univariate regression showed that the CT genotype was significantly associated with higher blood glucose at 0 months (coefficient ± SE, 64 ± 4.7; p < 0.001), 3 (coefficient ± SE, 58 ± 4.0; p < 0.001), and 12 months (coefficient ± SE, 57 ± 3.2; p < 0.001), and with the development of diabetes and prediabetes after LDLT (coefficient ± SE, 0.6 ± 0.06; p < 0.001).
Conclusions
IL28B polymorphism is significantly associated with new onset diabetes after LDLT. CT genotype may represent a marker to identify high risk recipients.