Introduction
Materials and methods
Participants
Data collection
Statistical methods
Ethical approval
Results
Percentages of recurrence
Characteristics | Primary diagnosis (year) | ||
---|---|---|---|
1992–2009 | 2003–2009 | 2006–2007 | |
Number of women | 1798 | 825 | 242 |
Median age (years) (min.; max.) | 24.0 (2.0; 74.0) | 23.5 (2.0; 70.0) | 23.9 (15.0; 70.0) |
At least one recurrence | 306 (17.0%) | 141 (17.1%) | 68 (28.1%) |
One recurrence | 220 (12.2%) | 98 (11.9%) | 44 (18.2%) |
Two recurrences | 58 (3.2%) | 29 (3.5%) | 11 (4.4%) |
Three recurrences | 19 (1.1%) | 8 (1.0%) | 7 (2.9%) |
More than three recurrences | 9 (0.5%) | 5 (0.6%) | 6 (2.5%) |
Missing data | 1 (0.1%) | 1 (0.1%) | 0 (0.0%) |
Median time from primary treatment to first recurrence (weeks) (min.; max.) | 14.6 (1.6; 701.0) | 13.6 (1.6; 213.4) | 12.7 (2.3; 126.7) |
Time to recurrence
Additional data on topography, pregnancy status and cervical smear (data subset 1)
Sites of distribution | Number of patients (%) | Recurrence (%) |
---|---|---|
All | 825 | 141 (17.1%) |
Unifocal | 195 (23.6%) | 22 (11.3%) |
Vulva | 150 (18.2%) | 15 (10.0%) |
Perineum/perianal | 20 (2.4%) | 2 (10.0%) |
Vagina | 18 (2.2%) | 5 (27.8%) |
Cervix | 7 (0.9) | 0 (0%) |
Multifocal | 630 (76.4%) | 119 (18.9%) |
Vulva–perineum/perianal | 125 (15.2%) | 22 (17.6%) |
Vagina–vulva–perineum/perianal | 100 (12.1%) | 18 (18.0%) |
Vagina–vulva | 97 (11.8%) | 15 (15.5%) |
Vulva–perineum/perianal–anus | 82 (9.9%) | 14 (17.1%) |
Vagina–vulva–perineum/perianal–anus | 77 (9.3%) | 18 (23.4%) |
Cervix–vagina–vulva–perineum/perianal–anus | 25 (3.0%) | 6 (24.0%) |
Cervix–vagina–vulva | 23 (2.8%) | 5 (21.7%) |
Cervix–vagina–vulva–perineum/perianal | 20 (2.4%) | 4 (20.0%) |
Perineum/perianal–anus | 16 (1.9%) | 2 (12.5%) |
Cervix–vulva | 11 (1.3%) | 4 (36.4%) |
Vagina–vulva–anus | 10 (1.2%) | 3 (30.0%) |
Other combinations | 44 (5.3%) | 8 (18.2%) |
Number of affected sites | ||
One site | 195 (23.6%) | 22 (11.3%) |
Two sites | 269 (32.6%) | 45 (16.7%) |
Three sites | 226 (27.4%) | 44 (19.5%) |
Four sites | 110 (13.3%) | 24 (21.8%) |
Five sites | 25 (3.0%) | 6 (24.0%) |
Additional systematic follow-up data (data subset 2)
Regression coefficient B | Wald |
df
| Sig | HR | 95% Confidence Interval for HR | ||
---|---|---|---|---|---|---|---|
Lower | Upper | ||||||
Number of affected sites (0 = unifocal, 1 = multifocal) | 1.05 | 3.98 | 1 | 0.046 | 2.86 | 1.02 | 8.05 |
Site: Vagina | − 0.09 | 0.06 | 1 | 0.80 | 0.91 | 0.43 | 1.91 |
Site: Vulva | − 0.46 | 0.99 | 1 | 0.32 | 0.63 | 0.25 | 1.57 |
Site: Perineum/perianal region | − 0.11 | 0.09 | 1 | 0.77 | 0.89 | 0.43 | 1.87 |
Site: Anus | − 0.75 | 2.99 | 1 | 0.08 | 0.47 | 0.20 | 1.11 |
Age | − 0.03 | 2.23 | 1 | 0.14 | 0.97 | 0.93 | 1.01 |