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International Urology and Nephrology
Erschienen in: International Urology and Nephrology 12/2020

30.07.2020 | Nephrology - Original Paper

Reduced serum CTRP12 levels in type 2 diabetes are associated with renal dysfunction

verfasst von: Jinqiu Du, Jiajia Xu, Xiaoguang Wang, Yanyan Liu, Xue Zhao, Huijuan Zhang

Erschienen in: International Urology and Nephrology | Ausgabe 12/2020

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Abstract

Purpose

Serum C1q/TNF-related protein-12 (CTRP12) is one of the newly studied families of adipokines, which is believed to be associated with type 2 diabetes. However, the relationship between serum CTRP12 levels and diabetic nephropathy remains unclear. This study aimed to investigate the relationship between serum CTRP12 levels and renal function in patients with type 2 diabetes.

Methods

A total of 115 type 2 diabetic patients and 54 healthy subjects were enrolled in this study. 52 patients with type 2 diabetes were in the diabetes group (T2DM). The 63 patients with renal dysfunction were diabetic nephropathy group (T2DM-DN) and were divided into microalbuminuria subgroup (31 cases) and macroalbuminuria subgroup (32 cases) according to the 24-h urine protein excretion rate. The concentrations of serum CTRP12 were determined by enzyme-linked immunosorbent assay.

Results

Serum CTRP12 level in T2DM and T2DM-DN groups was significantly lower compared with the control group, while CTRP12 level in T2DM-DN group was significantly lower than that in T2DM group, and was associated with the severity of renal insufficiency. After adjusting for gender and age, serum CTRP12 level was negatively correlated with the duration of diabetes, blood urea nitrogen (BUN), uric acid (UA) and 24-h urinary albumin excretion rate (UAE) in T2DM patients. Logistic regression analysis showed that serum CTRP12 level was significantly associated with renal dysfunction in type 2 diabetes mellitus. And the duration of diabetes, total cholesterol (CHOL) and neutrophils/lymphocytes (NLR) are independent risk factors for renal dysfunction in type 2 diabetes mellitus.

Conclusion

Serum CTRP12 may be involved in the occurrence and development of diabetic nephropathy.
Trial registration number and date of registration ChiCTR2000030794, March 14, 2020.
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Metadaten
Titel
Reduced serum CTRP12 levels in type 2 diabetes are associated with renal dysfunction
verfasst von
Jinqiu Du
Jiajia Xu
Xiaoguang Wang
Yanyan Liu
Xue Zhao
Huijuan Zhang
Publikationsdatum
30.07.2020
Verlag
Springer Netherlands
Erschienen in
International Urology and Nephrology / Ausgabe 12/2020
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-020-02591-y

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