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Annals of Behavioral Medicine
Erschienen in: Annals of Behavioral Medicine 3/2008

01.06.2008 | Original Article

Relation Between Central Adiposity and Cognitive Function in the Maine–Syracuse Study: Attenuation by Physical Activity

verfasst von: Gregory A. Dore, B.A., Merrill F. Elias, Ph.D., M.P.H., Michael A. Robbins, Ph.D., Marc M. Budge, M.B.B.S., B.Med.Sc., Penelope K. Elias, Ph.D.

Erschienen in: Annals of Behavioral Medicine | Ausgabe 3/2008

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Abstract

Background

Previous studies have demonstrated a relationship between central adiposity and cognitive function. However, only some of these studies have adjusted for cardiovascular risk factors and cardiovascular disease, and none have also adjusted for physical activity level.

Purpose

The purpose of the study was to examine the association between anthropometric measures of central adiposity (waist circumference and waist/hip ratio) and cognitive functioning with adjustment for cardiovascular disease risk factors and physical activity.

Methods

Participants were 917 stroke- and dementia-free community-dwelling adults (59% women) in the Maine–Syracuse Study. The design was cross-sectional. Outcome measures included tests from the Wechsler Adult Intelligence Scale, the Halstead-Reitan Neuropsychological Battery, the Wechsler Memory Scale Revised, and the Mini-Mental State Examination.

Results

Waist circumference and waist/hip ratio were inversely related to multiple cognitive domains with adjustment for age, education, gender, and number of prior exams. For example, a 20-cm increment in waist circumference was associated with a 0.14 SD decrement in the Global Composite score. These relations were attenuated with adjustment for cardiovascular disease risk factors. However, with further adjustment for physical activity level, only waist circumference remained significantly associated with performance on the Similarities test.

Conclusions

Waist circumference and waist/hip ratio are inversely related to cognitive function. Measures of central adiposity predict cognitive function independently of associated cardiovascular risk factors and events; however, the association between central adiposity and cognitive function is attenuated, to a large extent, by adjustment for physical activity level. Physical activity is an important covariate in studies relating measures of central adiposity to cognition.
Literatur
1.
Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW Jr. Body-mass index and mortality in a prospective cohort of US adults. N Engl J Med. 1999; 341: 1097–1105.PubMedCrossRef
2.
Cabrera MA, Gebara OC, Diament J, Nussbacher A, Rosano G, Wajngarten M. Metabolic syndrome, abdominal obesity, and cardiovascular risk in elderly women. Int J Cardiol. 2007; 114: 224–229.PubMedCrossRef
3.
Jonsson S, Hedblad B, Engstrom G, Nilsson P, Berglund G, Janzon L. Influence of obesity on cardiovascular risk. Twenty-three-year follow-up of 22,025 men from an urban Swedish population. Int J Obes Relat Metab Disord. 2002; 26: 1046–1053.PubMedCrossRef
4.
Grundy SM, Brewer HB Jr., Cleeman JI, Smith SC Jr., Lenfant C. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004; 109: 433–438.PubMedCrossRef
5.
Elias MF, Elias PK, Sullivan LM, Wolf PA, D’Agostino RB. Lower cognitive function in the presence of obesity and hypertension: The Framingham heart study. Int J Obes Relat Metab Disord. 2003; 27: 260–268.PubMedCrossRef
6.
Gunstad J, Paul RH, Cohen RA, Tate DF, Gordon E. Obesity is associated with memory deficits in young and middle-aged adults. Eat Weight Disord. 2006; 11: e15–e19.PubMed
7.
Cournot M, Marquie JC, Ansiau D, et al. Relation between body mass index and cognitive function in healthy middle-aged men and women. Neurology. 2006; 67: 1208–1214.PubMedCrossRef
8.
Dixon JB, Strauss BJ, Laurie C, O’Brien PE. Smaller hip circumference is associated with dyslipidemia and the metabolic syndrome in obese women. Obes Surg. 2007; 17: 770–777.PubMedCrossRef
9.
Bigaard J, Frederiksen K, Tjonneland A, et al. Waist circumference and body composition in relation to all-cause mortality in middle-aged men and women. Int J Obes. 2005; 29: 778–784.CrossRef
10.
Simpson JA, MacInnis RJ, Peeters A, Hopper JL, Giles GG, English DR. A comparison of adiposity measures as predictors of all-cause mortality: The Melbourne Collaborative Cohort Study. Obesity. 2007; 15: 994–1003.PubMedCrossRef
11.
Baik I, Ascherio A, Rimm EB, et al. Adiposity and mortality in men. Am J Epidemiol. 2000; 152: 264–271.PubMedCrossRef
12.
Yusuf S, Hawken S, Ounpuu S, et al. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: A case-control study. Lancet. 2005; 366: 1640–1649.PubMedCrossRef
13.
Waldstein SR, Katzel LI. Interactive relations of central versus total obesity and blood pressure to cognitive function. Int J Obes. 2006; 30: 201–207.CrossRef
14.
Wolf PA, Beiser A, Elias MF, Au R, Vasan RS, Seshadri S. Relation of obesity to cognitive function: Importance of central obesity and synergistic influence of concomitant hypertension. The Framingham Heart Study. Curr Alzheimer Res. 2007; 4: 111–116.PubMedCrossRef
15.
Hillman CH, Motl RW, Pontifex MB, et al. Physical activity and cognitive function in a cross-section of younger and older community-dwelling individuals. Health Psychol. 2006; 25: 678–687.PubMedCrossRef
16.
Kramer AF, Colcombe SJ, McAuley E, Scalf PE, Erickson KI. Fitness, aging and neurocognitive function. Neurobiol Aging. 2005; 26Suppl 1: 124–127.PubMedCrossRef
17.
Weuve J, Kang JH, Manson JE, Breteler MM, Ware JH, Grodstein F. Physical activity, including walking, and cognitive function in older women. JAMA. 2004; 292: 1454–1461.PubMedCrossRef
18.
Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults: A meta-analytic study. Psychol Sci. 2003; 14: 125–130.PubMedCrossRef
19.
Hu G, Tuomilehto J, Silventoinen K, Barengo NC, Peltonen M, Jousilahti P. The effects of physical activity and body mass index on cardiovascular, cancer and all-cause mortality among 47 212 middle-aged Finnish men and women. Int J Obes. 2005; 29: 894–902.CrossRef
20.
Telford RD. Low physical activity and obesity: Causes of chronic disease or simply predictors? Med Sci Sports Exerc. 2007; 39: 1233–1240.PubMedCrossRef
21.
Elias MF, Robbins MA, Budge MM, et al. Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: The Maine-Syracuse study. Psychosom Med. 2006; 68: 547–554.PubMedCrossRef
22.
Robbins MA, Elias MF, Elias PK, Budge MM. Blood pressure and cognitive function in an African-American and a Caucasian-American sample: The Maine-Syracuse Study. Psychosom Med. 2005; 67: 707–714.PubMedCrossRef
23.
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology. 1984; 34: 939–944.PubMed
24.
Radloff LS. The CES-D Scale: A self-report depression scale for research in the general population. Appl Psychol Meas. 1977; 1: 385–401.CrossRef
25.
Lezak MD, Howieson DB, Loring DW. Neuropsychological assessment. 4th ed. New York: Oxford University Press; 2004.
26.
Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12: 189–198.PubMedCrossRef
27.
Dore GA, Elias MF, Robbins MA, Elias PK, Brennan SL. Cognitive performance and age: Norms from the Maine-Syracuse Study. Exp Aging Res. 2007; 33: 205–271.PubMedCrossRef
28.
Elias MF, Robbins MA, Budge MM, et al. Homocysteine and cognitive performance: Modification by the ApoE genotype. Neurosci Lett. 2008; 430: 64–69.PubMedCrossRef
29.
Robbins MA, Elias MF, Budge MM, Brennan SL, Elias PK. Homocysteine, type 2 diabetes mellitus, and cognitive performance: The Maine-Syracuse Study. Clin Chem Lab Med. 2005; 43: 1101–1106.PubMedCrossRef
30.
Wechsler D. Manual for the Wechsler Adult Intelligence Scale. New York: Psychological; 1955.
31.
Brandt J. The hopkins verbal learning test: Development of a new memory test with six equivalent forms. Clin Neuropsychol. 1991; 5: 125–142.CrossRef
32.
Boyd JL. A validity study of the Hooper Visual Organization Test. J Consult Clin Psychol. 1981; 49: 15–19.PubMedCrossRef
33.
Johnstone B, Wilhelm KL. The construct validity of the Hooper Visual Organization Test. Assessment. 1997; 4: 243–248.
34.
Benton AL, Hamsher K de S. Multilingual Aphasia Examination. Iowa: AJA; 1989.
35.
Reitan RM, Wolfson D. The Halstead-Reitan Neuropsychological Test battery: Theory and clinical interpretation. Tucson: Neuropsychology; 1993.
36.
Wechsler D. Manual for the Wechsler Memory Scale—Revised. New York: Psychological; 1987.
37.
Wechsler D. Wechsler Adult Intelligence Scale. 3rd ed. San Antonio: Psychological; 1997.
38.
Ridker PM. High-sensitivity C-reactive protein: Potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation. 2001; 103: 1813–1818.PubMed
39.
Whooley MA, Kiefe CI, Chesney MA, Markovitz JH, Matthews K, Hulley SB. Depressive symptoms, unemployment, and loss of income: The CARDIA Study. Arch Intern Med. 2002; 162: 2614–2620.PubMedCrossRef
40.
Wolf AM, Hunter DJ, Colditz GA, et al. Reproducibility and validity of a self-administered physical activity questionnaire. Int J Epidemiol. 1994; 23: 991–999.PubMedCrossRef
41.
Ainsworth BE, Haskell WL, Leon AS, et al. Compendium of physical activities: Classification of energy costs of human physical activities. Med Sci Sports Exerc. 1993; 25: 71–80.PubMedCrossRef
42.
Ford ES, Mokdad AH, Giles WH. Trends in waist circumference among U.S. adults. Obes Res. 2003; 11: 1223–1231.PubMedCrossRef
43.
Singh-Manoux A, Hillsdon M, Brunner E, Marmot M. Effects of physical activity on cognitive functioning in middle age: Evidence from the Whitehall II prospective cohort study. Am J Public Health. 2005; 95: 2252–2258.PubMedCrossRef
44.
Deary IJ, Whalley LJ, Batty GD, Starr JM. Physical fitness and lifetime cognitive change. Neurology. 2006; 67: 1195–1200.PubMedCrossRef
45.
Jagust W, Harvey D, Mungas D, Haan M. Central obesity and the aging brain. Arch Neurol. 2005; 62: 1545–1548.PubMedCrossRef
46.
Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004; 89: 2548–2556.PubMedCrossRef
47.
Slentz CA, Houmard JA, Kraus WE. Modest exercise prevents the progressive disease associated with physical inactivity. Exerc Sport Sci Rev. 2007; 35: 18–23.PubMedCrossRef
48.
Meeusen R. Exercise and the brain: Insight in new therapeutic modalities. Ann Transplant. 2005; 10: 49–51.PubMed
49.
Gill JM. Physical activity, cardiorespiratory fitness and insulin resistance: A short update. Curr Opin Lipidol. 2007; 18: 47–52.PubMedCrossRef
50.
Mitchell RL, Phillips LH. The psychological, neurochemical and functional neuroanatomical mediators of the effects of positive and negative mood on executive functions. Neuropsychologia. 2007; 45: 617–629.PubMedCrossRef
51.
van der Meulen JA, Joosten RN, de Bruin JP, Feenstra MG. Dopamine and noradrenaline efflux in the medial prefrontal cortex during serial reversals and extinction of instrumental goal-directed behavior. Cereb Cortex. 2007; 17: 1444–1453.PubMedCrossRef
52.
Di Bonito P, Di Fraia L, Di Gennaro L, et al. Impact of impaired fasting glucose and other metabolic factors on cognitive function in elderly people. Nutr Metab Cardiovasc Dis. 2007; 17: 203–208.PubMedCrossRef
53.
Wilund KR. Is the anti-inflammatory effect of regular exercise responsible for reduced cardiovascular disease? Clin Sci. 2007; 112: 543–555.PubMedCrossRef
54.
Steffen PR, Sherwood A, Gullette EC, Georgiades A, Hinderliter A, Blumenthal JA. Effects of exercise and weight loss on blood pressure during daily life. Med Sci Sports Exerc. 2001; 33: 1635–1640.PubMedCrossRef
55.
Adamu B, Sani MU, Abdu A. Physical exercise and health: A review. Niger J Med. 2006; 15: 190–196.PubMed
56.
van Praag H, Christie BR, Sejnowski TJ, Gage FH. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci U S A. 1999; 96: 13427–13431.PubMedCrossRef
57.
van Praag H, Kempermann G, Gage FH. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci. 1999; 2: 266–270.PubMedCrossRef
58.
Yaffe K, Barnes D, Nevitt M, Lui LY, Covinsky K. A prospective study of physical activity and cognitive decline in elderly women: Women who walk. Arch Intern Med. 2001; 161: 1703–1708.PubMedCrossRef
59.
Haskell WL, Lee I, Pate RR, et al. Physical activity and public health: Updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc. 2007; 39: 1423–1434.PubMedCrossRef
Metadaten
Titel
Relation Between Central Adiposity and Cognitive Function in the Maine–Syracuse Study: Attenuation by Physical Activity
verfasst von
Gregory A. Dore, B.A.
Merrill F. Elias, Ph.D., M.P.H.
Michael A. Robbins, Ph.D.
Marc M. Budge, M.B.B.S., B.Med.Sc.
Penelope K. Elias, Ph.D.
Publikationsdatum
01.06.2008
Verlag
Springer-Verlag
Erschienen in
Annals of Behavioral Medicine / Ausgabe 3/2008
Print ISSN: 0883-6612
Elektronische ISSN: 1532-4796
DOI
https://doi.org/10.1007/s12160-008-9038-7

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