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01.02.2015 | Original Article

Relations of vitamin D status, gender and type 2 diabetes in middle-aged Caucasians

verfasst von: Andreas Stadlmayr, Elmar Aigner, Ursula Huber-Schönauer, David Niederseer, Jochen Zwerina, Emma Husar-Memmer, Florian Hohla, Georg Schett, Wolfgang Patsch, Christian Datz

Erschienen in: Acta Diabetologica | Ausgabe 1/2015

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Abstract

Vitamin D (Vit D) deficiency may be linked to the development of obesity-associated complications such as insulin resistance and type 2 diabetes. We therefore evaluated the relationship of Vit D serum concentrations with metabolic parameters and type 2 diabetes in middle-aged Caucasian men and women. One thousand six hundred and thirty-one Caucasians (832 males, 58.8 ± 9.7 years; 799 females, 59.7 ± 10.7 years) were evaluated in a cross-sectional study. Vit D status was assessed by measuring the serum concentration of 25-hydroxyvitamin D₃ [25(OH)D₃]. Type 2 diabetes prevalence was ascertained by medical history, fasting plasma glucose concentrations, oral glucose tolerance testing and/or glycosylated hemoglobin. Men displayed higher crude or seasonally adjusted 25(OH)D₃ serum concentrations than women (24.64 ± 10.98 vs. 22.88 ± 11.6 ng/ml; P < 0.001). Strong associations between body mass index (BMI) and 25(OH)D₃ were observed in both genders (P < 0.001). Seasonally adjusted levels of 25(OH)D₃ revealed stronger associations with type 2 diabetes in women than men (P < 0.001). However, adjustment for BMI and other confounding variables revealed an independent inverse association of 25(OH)D₃ with diabetes only in women (P < 0.001), whereas the association was abrogated in men. Using a 15 ng/ml 25(OH)D₃ cutoff for binary comparison, adjusted odds ratios for having newly diagnosed or known type 2 diabetes more than doubled (2.95 [95 % CI 1.37–4.89] and 3.26 [1.59–6.68], respectively), in women below the cutoff. We conclude that in women, but not in men, low 25(OH)D₃ serum levels are independently associated with type 2 diabetes. These findings suggest sex-specific effects of Vit D in the pathogenesis of type 2 diabetes.

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Titel: Relations of vitamin D status, gender and type 2 diabetes in middle-aged Caucasians
verfasst von: Andreas Stadlmayr
Elmar Aigner
Ursula Huber-Schönauer
David Niederseer
Jochen Zwerina
Emma Husar-Memmer
Florian Hohla
Georg Schett
Wolfgang Patsch
Christian Datz
Publikationsdatum: 01.02.2015
Verlag: Springer Milan
Erschienen in: Acta Diabetologica / Ausgabe 1/2015
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-014-0596-9

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Relations of vitamin D status, gender and type 2 diabetes in middle-aged Caucasians

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