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Graefe's Archive for Clinical and Experimental Ophthalmology

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01.05.2017 | Glaucoma

Relationship between laser speckle flowgraphy and optical coherence tomography angiography measurements of ocular microcirculation

verfasst von: Naoki Kiyota, Hiroshi Kunikata, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 8/2017

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Abstract

Purpose

The purpose of this study was to investigate the relationship between laser speckle flowgraphy (LSFG) and optical coherence tomography angiography (OCTA) measurements of ocular microcirculation in normal and open-angle glaucoma (OAG) subjects.

Methods

This study included 18 eyes of 18 OAG patients and ten eyes of ten age-matched healthy controls. LSFG was used to measure mean blur rate (MBR) in the optic nerve head (ONH) vessel area (MV) and tissue area (MT). OCTA was used to measure a new parameter, peripapillary relative intensity (PRI), in the superficial retina, superficial choroid, and deep choroid. Statistical associations were then determined.

Results

MV, MT, superficial-retinal PRI, and superficial-choroidal PRI were lower in the OAG subjects than the controls (P = 0.02, P < 0.001, P = 0.02 and P = 0.008, respectively). Superficial-retinal PRI was correlated with MV and MT (R = 0.68, P < 0.001 and R = 0.63, P < 0.001, respectively). Superficial-choroidal PRI was also correlated with MV and MT (R = 0.45, P = 0.02 and R = 0.57, P = 0.002, respectively). Multiple regression analysis revealed that MV and MT independently contributed to superficial-retinal PRI (P = 0.008 and P = 0.04, respectively), while only MT contributed to superficial-choroidal PRI (P = 0.03).

Conclusions

Our finding that OCTA-measured PRI was related to LSFG-measured MBR was reasonable, considering the vascular anatomy of the eye. Thus, PRI, like MBR, may be a promising biomarker of ocular microcirculation that can reveal the presence of ocular diseases such as OAG.

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Titel: Relationship between laser speckle flowgraphy and optical coherence tomography angiography measurements of ocular microcirculation
verfasst von: Naoki Kiyota
Hiroshi Kunikata
Yukihiro Shiga
Kazuko Omodaka
Toru Nakazawa
Publikationsdatum: 01.05.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 8/2017
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-017-3627-8

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Relationship between laser speckle flowgraphy and optical coherence tomography angiography measurements of ocular microcirculation

Abstract

Purpose

Methods

Results

Conclusions

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Springer Medizin

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