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European Journal of Orthopaedic Surgery & Traumatology

Erschienen in:

01.05.2014 | Original Article

Relationship between post-SARS osteonecrosis and PAI-1 4G/5G gene polymorphisms

verfasst von: Wei Sun, Zirong Li, Zhengcai Shi, Bailiang Wang, Fuqiang Gao, Yurun Yang, Wanshou Guo

Erschienen in: European Journal of Orthopaedic Surgery & Traumatology | Ausgabe 4/2014

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Abstract

Objective

To explore the correlation between post-severe acute respiratory symptom (SARS) patients with osteonecrosis, investigate the etiology of post-SARS osteonecrosis and select the sensitive molecular symbols for early diagnosis and distinguish the high-risk population.

Methods

The studied subjects were divided into two groups. Sixty-two post-SARS patients with osteonecrosis were one group, and 52 age- and sex-matched healthy people were as normal controlled group. Empty stomach blood samples from cubital veins were collected from both groups. Plasminogen activator inhibitor (PAI) by means of enzyme-linked immunosorbent assay and PAI-1 4G/5G polymorphism was detected by polymerase chain reaction and solid phase oligonucleotide assay.

Results

The blood agents of post-SARS patients changed obviously with 15.64 ± 13.85 U/ml while the control group 7.96 ± 4.27 U/ml; 4G/4G genotype for the PAI-1 polymorphism detected in post-SARS group was more than that of the control group, but had no statistical significance. The plasma PAI activity was related to homozygote 4G/4G genotype. This reveals that homozygote 4G/4G genotype may be a susceptible gene mark to Chinese osteonecrosis patients.

Conclusion

Plasminogen activator inhibitor-1 is sensitive blood symbol for screening high-risk susceptible population; 4G/4G PAI-1 genotype may be an etiological factor in osteonecrosis.

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Titel: Relationship between post-SARS osteonecrosis and PAI-1 4G/5G gene polymorphisms
verfasst von: Wei Sun
Zirong Li
Zhengcai Shi
Bailiang Wang
Fuqiang Gao
Yurun Yang
Wanshou Guo
Publikationsdatum: 01.05.2014
Verlag: Springer Paris
Erschienen in: European Journal of Orthopaedic Surgery & Traumatology / Ausgabe 4/2014
Print ISSN: 1633-8065
Elektronische ISSN: 1432-1068
DOI: https://doi.org/10.1007/s00590-013-1223-0

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Relationship between post-SARS osteonecrosis and PAI-1 4G/5G gene polymorphisms

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