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01.12.2018 | Research article | Ausgabe 1/2018 Open Access

BMC Cancer 1/2018

Relationship between the extent of resection and the survival of patients with low-grade gliomas: a systematic review and meta-analysis

Zeitschrift:
BMC Cancer > Ausgabe 1/2018
Autoren:
Liang Xia, Chenyan Fang, Gao Chen, Caixing Sun
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s12885-017-3909-x) contains supplementary material, which is available to authorized users.

Abstract

Background

Surgical resection is necessary to conduct a pathological biopsy and to achieve a reduction of intracranial pressure in low-grade gliomas patients. This study aimed to determine whether a greater extent of resection would increase the overall 5-year and 10-year survival of patients with low-grade gliomas.

Methods

The studies addressing relationship between the extent of resection and the prognosis of low-grade gliomas updated until March 2017 were systematically searched in two databases (Pubmed and EMBASE). The relationships among categorical variables were analyzed using an odds ratio (OR) and a95% confidence interval (CI). Significance was established using CIs at a level of 95% or P < 0.05. Funnel plot was used to detect the publication bias.

Results

Twenty articles (a total of 2128 patients) were identified. The meta-analysis showed that the 5-year (Odds ratio (OR), 3.90;95% Confidence Interval (CI), 2.79~5.45; P < 0.01; Z = 7.95) and 10-year OS (OR, 7.91; 95%CI, 5.12~12.22; P < 0.01; Z = 9.33) associated with gross total resection (GTR) were higher than those associated with subtotal resection (STR). Similarly, as compared with biopsy(BX), the 5-year and 10-year OS were higher after either GTR (5-year: OR, 5.43; 95%CI, 3.57~8.26; P < 0.01; Z = Z = 7.9; 10-year: OR, 10.17; 95%CI, 4.02~25.71; P < 0.00001; Z = 4.9) or STR (5-year: OR, 2.59; 95%CI, 1.81~ − 3.71; P < 0.00001; Z = 5.19; 10-year: OR, 2.21; 95%CI, 1.164.25; P = 0.02; Z = 2.39).

Conclusions

Our research found that a greater extent of resection could significantly increase the OS of patients with low-grade gliomas.
Zusatzmaterial
Additional file 1: Supplementary Appendix 1. (DOC 28 kb)
12885_2017_3909_MOESM1_ESM.doc
Additional file 2: eFigure S1. Funnel plot for the 5-year mortality for GTR vs STR meta-analysis. The midline of the studies indicates a slight publication bias of studies showing benefit with GTR over STR. (PDF 12 kb)
12885_2017_3909_MOESM2_ESM.pdf
Additional file 3: eFigure S2. Funnel plot for the 5-year mortality for GTR vs BX meta-analysis. The midline of the studies indicates a slight publication bias of studies showing benefit with GTR over STR. (PDF 12 kb)
12885_2017_3909_MOESM3_ESM.pdf
Additional file 4: eFigure S3A. Funnel plot for the 5-year mortality for STR vs BX meta-analysis. The midline of the studies indicates a slight publication bias of studies showing benefit with GTR over STR (All related studies were included). eFigure3B. Funnel plot for the 5-year mortality for STR vs BX meta-analysis. The midline of the studies indicates a slight publication bias of studies showing benefit with GTR over STR (All related studies except one high heterogeneous study were included). (PDF 2433 kb)
12885_2017_3909_MOESM4_ESM.pdf
Additional file 5: eFigure S4. Funnel plot for the 10-year mortality for GTR vs STR meta-analysis. The midline of the studies indicates a slight publication bias of studies showing benefit with GTR over STR. (PDF 12 kb)
12885_2017_3909_MOESM5_ESM.pdf
Additional file 6: eFigure S5. Funnel plot for the 5-year mortality for GTR vs BX meta-analysis. The midline of the studies indicates a slight publication bias of studies showing benefit with GTR over STR. (PDF 12 kb)
12885_2017_3909_MOESM6_ESM.pdf
Additional file 7: eFigure S6. Funnel plot for the 5-year mortality for STR vs BX meta-analysis. The midline of the studies indicates a slight publication bias of studies showing benefit with GTR over STR. (PDF 12 kb)
12885_2017_3909_MOESM7_ESM.pdf
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