Skip to main content
Erschienen in: Digestive Diseases and Sciences 10/2006

01.10.2006 | Basic Research

Remission of Digestive Insufficiency by Islet Transplantation to the Pancreas

verfasst von: John I. Stagner, Horacio L. Rilo, Karen Wyler

Erschienen in: Digestive Diseases and Sciences | Ausgabe 10/2006

Einloggen, um Zugang zu erhalten

Abstract

Pancreatic digestive insufficiency is a common problem in both Type 1 and Type 2 diabetes and remains a serious consequence of diabetes in developing countries. The problem is not corrected by supportive therapies including exogenous insulin injections. It is our hypothesis that digestive insufficiency may be corrected or diminished by the transplantation of islets to the pancreas, thereby supplying islet hormones directly to acinar tissue analogous to the normal pancreas. Diabetic rats received 1000 syngeneic islets and dogs received 7600 autologous islets per kilogram as a transplant to the pancreas. Blood glucose and amylase concentrations were normalized in islet recipients in contrast with controls receiving no islets or islets transplanted to the renal capsule. These results suggest that diabetic digestive insufficiency may be corrected by intrapancreatic islet transplantation.
Literatur
1.
Zurück zum Zitat Frier BM, Saunders JHD, Wormsley KG, Bouchier LAD (1976) Exocrine pancreatic function in juvenile-onset diabetes mellitus. Gut 17:685–691PubMed Frier BM, Saunders JHD, Wormsley KG, Bouchier LAD (1976) Exocrine pancreatic function in juvenile-onset diabetes mellitus. Gut 17:685–691PubMed
2.
Zurück zum Zitat Kawamori R, Katsura M, Isheida S, Yamasaki Y (1995) Substantial exocrine pancreatic derangement in human diabetic patients evaluated from pure pancreatic juice. J Diabet Complicat 9:69–73CrossRef Kawamori R, Katsura M, Isheida S, Yamasaki Y (1995) Substantial exocrine pancreatic derangement in human diabetic patients evaluated from pure pancreatic juice. J Diabet Complicat 9:69–73CrossRef
3.
Zurück zum Zitat Loini R, Cortoni L, Scotta M, Melze d’Eril G, Seve F (1990) Exocrine pancreatic function in children with insulin dependent diabetes mellitus. Diabetes Res Clin Pract 8:261–267 Loini R, Cortoni L, Scotta M, Melze d’Eril G, Seve F (1990) Exocrine pancreatic function in children with insulin dependent diabetes mellitus. Diabetes Res Clin Pract 8:261–267
4.
Zurück zum Zitat Rothenbacker D, Low M, Hardt P, Klor H-U, Ziegler H, Brenner H (2005) Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study. Scand J Gastroenterol 40:697–704 Rothenbacker D, Low M, Hardt P, Klor H-U, Ziegler H, Brenner H (2005) Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study. Scand J Gastroenterol 40:697–704
5.
Zurück zum Zitat Hardt PD, Krauss A, Bretz L, Porsch-Ozcurumez M, Schnell-Ketschmer H, Maser E, Bretzel RG, Zekhorn T, Klor H-U (2000) Pancreatic exocrine function in patients with Type 1 and Type 2 diabetes mellitus. Acta Diabetol 37:105–110PubMedCrossRef Hardt PD, Krauss A, Bretz L, Porsch-Ozcurumez M, Schnell-Ketschmer H, Maser E, Bretzel RG, Zekhorn T, Klor H-U (2000) Pancreatic exocrine function in patients with Type 1 and Type 2 diabetes mellitus. Acta Diabetol 37:105–110PubMedCrossRef
6.
Zurück zum Zitat Nakagawa A, Stagner JI, Samols E (1993) Suppressive role of the islet-acinar axis in the perfused rat pancreas. Gastroenterology 105:868–875PubMed Nakagawa A, Stagner JI, Samols E (1993) Suppressive role of the islet-acinar axis in the perfused rat pancreas. Gastroenterology 105:868–875PubMed
7.
Zurück zum Zitat Nakagawa A, Samols E, Stagner JI (1993) Interstitial acinar islet hormone concentrations in the dog pancreas. Am J Physiol 264:G728–G734PubMed Nakagawa A, Samols E, Stagner JI (1993) Interstitial acinar islet hormone concentrations in the dog pancreas. Am J Physiol 264:G728–G734PubMed
8.
Zurück zum Zitat Kvist-Reimer M, Mokshagundam SP, Wyler K, Sundler F, Ahren B, Stagner J (2003) Beneficial effect of local growth factor treatment on autonomic reinnervation of transplanted pancreatic islets in rats. Pancreas 29:392–397CrossRef Kvist-Reimer M, Mokshagundam SP, Wyler K, Sundler F, Ahren B, Stagner J (2003) Beneficial effect of local growth factor treatment on autonomic reinnervation of transplanted pancreatic islets in rats. Pancreas 29:392–397CrossRef
9.
Zurück zum Zitat Stagner JI, Mokshagundam SP, Samols E (1998) Induction of mild hypoglycemia by islet transplantation to the pancreas. Transplant Proc 30:635–636PubMedCrossRef Stagner JI, Mokshagundam SP, Samols E (1998) Induction of mild hypoglycemia by islet transplantation to the pancreas. Transplant Proc 30:635–636PubMedCrossRef
10.
Zurück zum Zitat Rodriguez-Rilo HL, Carroll PB, Zeng YJ, Fontes P, Demetris J, Ricordi C (1994) Acceleration of chronic failure of intrahepatic canine islet autografts by a short course of prednisone. Transplantation 57:181–187CrossRef Rodriguez-Rilo HL, Carroll PB, Zeng YJ, Fontes P, Demetris J, Ricordi C (1994) Acceleration of chronic failure of intrahepatic canine islet autografts by a short course of prednisone. Transplantation 57:181–187CrossRef
11.
Zurück zum Zitat Samols E, Stagner JI (1996) Intra-islet cell-cell interactions and insulin secretion. Diabetes Rev 4:207–223 Samols E, Stagner JI (1996) Intra-islet cell-cell interactions and insulin secretion. Diabetes Rev 4:207–223
12.
Zurück zum Zitat Williams JA, Goldfine ID (1985) The insulin-pancretic acinar axis. Diabetes 34:980–986PubMed Williams JA, Goldfine ID (1985) The insulin-pancretic acinar axis. Diabetes 34:980–986PubMed
13.
Zurück zum Zitat Holst JJ (1987) Does the endocrine secretion of the pancreas exert a local control of the exocrine secretion? Pancreas 2:613–619PubMedCrossRef Holst JJ (1987) Does the endocrine secretion of the pancreas exert a local control of the exocrine secretion? Pancreas 2:613–619PubMedCrossRef
14.
Zurück zum Zitat Garry DJ, Garry MG, Williams JA, Mahoneey WC, Sorenson RL (1989) Effects of islet hormones on amylase secretion and localization of somatostatin binding sites. Am J Physiol 56:G897–G904 Garry DJ, Garry MG, Williams JA, Mahoneey WC, Sorenson RL (1989) Effects of islet hormones on amylase secretion and localization of somatostatin binding sites. Am J Physiol 56:G897–G904
15.
Zurück zum Zitat Kimmel JD, Pollaock HG (1981) Target organs for avain pancreatic polypeptide. Endocrinology 109:1693–1699PubMedCrossRef Kimmel JD, Pollaock HG (1981) Target organs for avain pancreatic polypeptide. Endocrinology 109:1693–1699PubMedCrossRef
16.
Zurück zum Zitat Louie DS, Williams JA, Owyang C (1985) Action of pancreatic polypeptide on rat pancreatic secretion in vivo and in vitro. Am J Physiol 249:G489–G495 Louie DS, Williams JA, Owyang C (1985) Action of pancreatic polypeptide on rat pancreatic secretion in vivo and in vitro. Am J Physiol 249:G489–G495
17.
Zurück zum Zitat Nakagawa A, Stagner JI, Samols E (1995) In situ binding of islet hormones in the isolated rat pancreas. Evidence for local high concentrations of islet hormones via the islet-acinar axis. Diabetologia 38:262–268PubMed Nakagawa A, Stagner JI, Samols E (1995) In situ binding of islet hormones in the isolated rat pancreas. Evidence for local high concentrations of islet hormones via the islet-acinar axis. Diabetologia 38:262–268PubMed
18.
Zurück zum Zitat Ryan EA, Paty BW, Senior PA, Bigam D, Alfadhi E, Kneteman NM, Lakey JRT, Shapiro AMJ (2005) Five-year follow-up after clinical islet transplantation. Diabetes 54:2060–2069PubMed Ryan EA, Paty BW, Senior PA, Bigam D, Alfadhi E, Kneteman NM, Lakey JRT, Shapiro AMJ (2005) Five-year follow-up after clinical islet transplantation. Diabetes 54:2060–2069PubMed
19.
Zurück zum Zitat Warnock GL, Rajotte RV (1988) Critical mass of purified islets that induce normoglycemia after implantation into dogs. Diabetes 37:467–470PubMed Warnock GL, Rajotte RV (1988) Critical mass of purified islets that induce normoglycemia after implantation into dogs. Diabetes 37:467–470PubMed
Metadaten
Titel
Remission of Digestive Insufficiency by Islet Transplantation to the Pancreas
verfasst von
John I. Stagner
Horacio L. Rilo
Karen Wyler
Publikationsdatum
01.10.2006
Erschienen in
Digestive Diseases and Sciences / Ausgabe 10/2006
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-006-9300-4

Weitere Artikel der Ausgabe 10/2006

Digestive Diseases and Sciences 10/2006 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Triglyzeridsenker schützt nicht nur Hochrisikopatienten

10.05.2024 Hypercholesterinämie Nachrichten

Patienten mit Arteriosklerose-bedingten kardiovaskulären Erkrankungen, die trotz Statineinnahme zu hohe Triglyzeridspiegel haben, profitieren von einer Behandlung mit Icosapent-Ethyl, und zwar unabhängig vom individuellen Risikoprofil.

Gibt es eine Wende bei den bioresorbierbaren Gefäßstützen?

In den USA ist erstmals eine bioresorbierbare Gefäßstütze – auch Scaffold genannt – zur Rekanalisation infrapoplitealer Arterien bei schwerer PAVK zugelassen worden. Das markiert einen Wendepunkt in der Geschichte dieser speziellen Gefäßstützen.

Vorsicht, erhöhte Blutungsgefahr nach PCI!

10.05.2024 Koronare Herzerkrankung Nachrichten

Nach PCI besteht ein erhöhtes Blutungsrisiko, wenn die Behandelten eine verminderte linksventrikuläre Ejektionsfraktion aufweisen. Das Risiko ist umso höher, je stärker die Pumpfunktion eingeschränkt ist.

Wie managen Sie die schmerzhafte diabetische Polyneuropathie?

10.05.2024 DDG-Jahrestagung 2024 Kongressbericht

Mit Capsaicin-Pflastern steht eine neue innovative Therapie bei schmerzhafter diabetischer Polyneuropathie zur Verfügung. Bei therapierefraktären Schmerzen stellt die Hochfrequenz-Rückenmarkstimulation eine adäquate Option dar.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.