Skip to main content
Erschienen in: Clinical Research in Cardiology 2/2012

01.02.2012 | Original Paper

Remote monitoring of heart failure patients using implantable cardiac pacing devices and external sensors: results of the Insight-HF study

verfasst von: Ann Lieback, Jochen Proff, Kai Wessel, Eckart Fleck, Stephan Götze

Erschienen in: Clinical Research in Cardiology | Ausgabe 2/2012

Einloggen, um Zugang zu erhalten

Abstract

Aim

The rapidly increasing prevalence and poor outcome of congestive heart failure have stimulated the development of different telemonitoring technologies. In this study, we monitored remotely self-measured body weight and blood pressure, in parallel with the data automatically transmitted by implantable cardioverter-defibrillators. The primary aim of this study was to evaluate the correlation between different parameters screened by these two telemonitoring systems.

Methods and results

Thirty-two patients in NYHA class III heart failure were followed for 164 ± 48 days after cardioverter-defibrillator implantation. In 29 patients, mean heart rate (MHR), resting heart rate (RHR), and patient activity (determined by implanted devices), weight and blood pressure measurements were received on 85% of all days when remote data transmissions were expected. Based on approximately 4,000 daily pairs of measurements pooled for all patients, weight inversely correlated with activity and with the difference between MHR and RHR. By contrast, blood pressure did not correlate with weight, activity, or the difference between MHR and RHR, but it correlated with MHR and RHR individually.

Conclusion

Body weight, patient activity, and the difference between MHR and RHR are mutually correlated and may reasonably contribute to an algorithm for predicting heart failure deterioration. Blood pressure appears to offer no additional value. As both genesis and symptoms of heart failure exacerbation are non-uniform and complex, the telemonitoring concepts for heart failure patients should employ continuous monitoring of multiple diagnostic parameters, rather than rely on a single parameter. Provided that patient compliance is strictly supervised, reliable data flow from sensors requiring patient involvement is possible.
Literatur
1.
Zurück zum Zitat Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJ, Ponikowski P, Poole-Wilson PA, Stromberg A, van Veldhuisen DJ, Atar D, Hoes AW, Keren A, Mebazaa A, Nieminen M, Priori SG, Swedberg K, Vahanian A, Camm J, De CR, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL (2008) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J 29:2388–2442PubMedCrossRef Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJ, Ponikowski P, Poole-Wilson PA, Stromberg A, van Veldhuisen DJ, Atar D, Hoes AW, Keren A, Mebazaa A, Nieminen M, Priori SG, Swedberg K, Vahanian A, Camm J, De CR, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL (2008) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J 29:2388–2442PubMedCrossRef
2.
Zurück zum Zitat Berry C, Murdoch DR, McMurray JJ (2001) Economics of chronic heart failure. Eur J Heart Fail 3:283–291PubMedCrossRef Berry C, Murdoch DR, McMurray JJ (2001) Economics of chronic heart failure. Eur J Heart Fail 3:283–291PubMedCrossRef
3.
Zurück zum Zitat McKee PA, Castelli WP, McNamara PM, Kannel WB (1971) The natural history of congestive heart failure: the Framingham Study. N Engl J Med 285:1441–1446PubMedCrossRef McKee PA, Castelli WP, McNamara PM, Kannel WB (1971) The natural history of congestive heart failure: the Framingham Study. N Engl J Med 285:1441–1446PubMedCrossRef
4.
Zurück zum Zitat McCullough PA, Philbin EF, Spertus JA, Kaatz S, Sandberg KR, Weaver WD (2002) Confirmation of a heart failure epidemic: findings from the Resource Utilization Among Congestive Heart Failure (REACH) study. J Am Coll Cardiol 39:60–69PubMedCrossRef McCullough PA, Philbin EF, Spertus JA, Kaatz S, Sandberg KR, Weaver WD (2002) Confirmation of a heart failure epidemic: findings from the Resource Utilization Among Congestive Heart Failure (REACH) study. J Am Coll Cardiol 39:60–69PubMedCrossRef
5.
Zurück zum Zitat Bundkirchen A, Schwinger RHG (2004) Epidemiology and economic burden of chronic heart failure. Eur Heart J Suppl 6(Suppl D):D57–D60CrossRef Bundkirchen A, Schwinger RHG (2004) Epidemiology and economic burden of chronic heart failure. Eur Heart J Suppl 6(Suppl D):D57–D60CrossRef
6.
Zurück zum Zitat Maric B, Kaan A, Ignaszewski A, Lear SA (2009) A systematic review of telemonitoring technologies in heart failure. Eur J Heart Fail 11:506–517PubMedCrossRef Maric B, Kaan A, Ignaszewski A, Lear SA (2009) A systematic review of telemonitoring technologies in heart failure. Eur J Heart Fail 11:506–517PubMedCrossRef
7.
Zurück zum Zitat Chaudhry SI, Wang Y, Concato J, Gill TM, Krumholz HM (2007) Patterns of weight change preceding hospitalization for heart failure. Circulation 116:1549–1554PubMedCrossRef Chaudhry SI, Wang Y, Concato J, Gill TM, Krumholz HM (2007) Patterns of weight change preceding hospitalization for heart failure. Circulation 116:1549–1554PubMedCrossRef
8.
Zurück zum Zitat Goldberg LR, Piette JD, Walsh MN, Frank TA, Jaski BE, Smith AL, Rodriguez R, Mancini DM, Hopton LA, Orav EJ, Loh E (2003) Randomized trial of a daily electronic home monitoring system in patients with advanced heart failure: the Weight Monitoring in Heart Failure (WHARF) trial. Am Heart J 146:705–712PubMedCrossRef Goldberg LR, Piette JD, Walsh MN, Frank TA, Jaski BE, Smith AL, Rodriguez R, Mancini DM, Hopton LA, Orav EJ, Loh E (2003) Randomized trial of a daily electronic home monitoring system in patients with advanced heart failure: the Weight Monitoring in Heart Failure (WHARF) trial. Am Heart J 146:705–712PubMedCrossRef
9.
Zurück zum Zitat Kimmelstiel C, Levine D, Perry K, Patel AR, Sadaniantz A, Gorham N, Cunnie M, Duggan L, Cotter L, Shea-Albright P, Poppas A, LaBresh K, Forman D, Brill D, Rand W, Gregory D, Udelson JE, Lorell B, Konstam V, Furlong K, Konstam MA (2005) Randomized, controlled evaluation of short- and long-term benefits of heart failure disease management within a diverse provider network: the SPAN-CHF trial. Circulation 110:1450–1455CrossRef Kimmelstiel C, Levine D, Perry K, Patel AR, Sadaniantz A, Gorham N, Cunnie M, Duggan L, Cotter L, Shea-Albright P, Poppas A, LaBresh K, Forman D, Brill D, Rand W, Gregory D, Udelson JE, Lorell B, Konstam V, Furlong K, Konstam MA (2005) Randomized, controlled evaluation of short- and long-term benefits of heart failure disease management within a diverse provider network: the SPAN-CHF trial. Circulation 110:1450–1455CrossRef
10.
Zurück zum Zitat Cleland JG, Louis AA, Rigby AS, Janssens U, Balk AH (2005) Noninvasive home telemonitoring for patients with heart failure at high risk of recurrent admission and death: the Trans-European Network-Home-Care Management System (TEN-HMS) study. J Am Coll Cardiol 45:1654–1664PubMedCrossRef Cleland JG, Louis AA, Rigby AS, Janssens U, Balk AH (2005) Noninvasive home telemonitoring for patients with heart failure at high risk of recurrent admission and death: the Trans-European Network-Home-Care Management System (TEN-HMS) study. J Am Coll Cardiol 45:1654–1664PubMedCrossRef
11.
Zurück zum Zitat Lewin J, Ledwidge M, O’Loughlin C, McNally C, McDonald K (2005) Clinical deterioration in established heart failure: what is the value of BNP and weight gain in aiding diagnosis? Eur J Heart Fail 7:953–957PubMedCrossRef Lewin J, Ledwidge M, O’Loughlin C, McNally C, McDonald K (2005) Clinical deterioration in established heart failure: what is the value of BNP and weight gain in aiding diagnosis? Eur J Heart Fail 7:953–957PubMedCrossRef
12.
Zurück zum Zitat Zhang J, Goode KM, Cuddihy PE, Cleland JG (2009) Predicting hospitalization due to worsening heart failure using daily weight measurement: analysis of the Trans-European Network-Home-Care Management System (TEN-HMS) study. Eur J Heart Fail 11:420–427PubMedCrossRef Zhang J, Goode KM, Cuddihy PE, Cleland JG (2009) Predicting hospitalization due to worsening heart failure using daily weight measurement: analysis of the Trans-European Network-Home-Care Management System (TEN-HMS) study. Eur J Heart Fail 11:420–427PubMedCrossRef
13.
Zurück zum Zitat Chaudhry SI, Mattera JA, Curtis JP, Spertus JA, Herrin J, Lin Z (2010) Telemonitoring in patients with heart failure. N Engl J Med 363:2301–2309PubMedCrossRef Chaudhry SI, Mattera JA, Curtis JP, Spertus JA, Herrin J, Lin Z (2010) Telemonitoring in patients with heart failure. N Engl J Med 363:2301–2309PubMedCrossRef
14.
Zurück zum Zitat Jung W, Rillig A, Birkemeyer R, Miljak T, Meyerfeldt U (2008) Advances in remote monitoring of implantable pacemakers, cardioverter defibrillators and cardiac resynchronization therapy systems. J Interv Card Electrophysiol 23:73–85PubMedCrossRef Jung W, Rillig A, Birkemeyer R, Miljak T, Meyerfeldt U (2008) Advances in remote monitoring of implantable pacemakers, cardioverter defibrillators and cardiac resynchronization therapy systems. J Interv Card Electrophysiol 23:73–85PubMedCrossRef
15.
Zurück zum Zitat Burri H, Senouf D (2009) Remote monitoring and follow-up of pacemakers and implantable cardioverter defibrillators. Europace 11:701–709PubMedCrossRef Burri H, Senouf D (2009) Remote monitoring and follow-up of pacemakers and implantable cardioverter defibrillators. Europace 11:701–709PubMedCrossRef
16.
Zurück zum Zitat Varma N, Epstein AE, Irimpen A, Schweikert R, Love C (2010) Efficacy and safety of automatic remote monitoring for implantable cardioverter-defibrillator follow-up: the Lumos-T Safely Reduces Routine Office Device Follow-up (TRUST) trial. Circulation 122:325–332PubMedCrossRef Varma N, Epstein AE, Irimpen A, Schweikert R, Love C (2010) Efficacy and safety of automatic remote monitoring for implantable cardioverter-defibrillator follow-up: the Lumos-T Safely Reduces Routine Office Device Follow-up (TRUST) trial. Circulation 122:325–332PubMedCrossRef
17.
Zurück zum Zitat Varma N, Michalski J, Epstein AE, Schweikert R (2010) Automatic remote monitoring of implantable cardioverter-defibrillator lead and generator performance: the Lumos-T Safely RedUceS RouTine Office Device Follow-Up (TRUST) trial. Circ Arrhythm Electrophysiol 3:428–436PubMedCrossRef Varma N, Michalski J, Epstein AE, Schweikert R (2010) Automatic remote monitoring of implantable cardioverter-defibrillator lead and generator performance: the Lumos-T Safely RedUceS RouTine Office Device Follow-Up (TRUST) trial. Circ Arrhythm Electrophysiol 3:428–436PubMedCrossRef
18.
Zurück zum Zitat Lazarus A (2007) Remote, wireless, ambulatory monitoring of implantable pacemakers, cardioverter defibrillators, and cardiac resynchronization therapy systems: analysis of a worldwide database. PACE 30:S2–S12PubMedCrossRef Lazarus A (2007) Remote, wireless, ambulatory monitoring of implantable pacemakers, cardioverter defibrillators, and cardiac resynchronization therapy systems: analysis of a worldwide database. PACE 30:S2–S12PubMedCrossRef
19.
Zurück zum Zitat Nielsen JC, Kottkamp H, Zabel M, Aliot E, Kreutzer U, Bauer A, Schuchert A, Neuser H, Schumacher B, Schmidinger H, Stix G, Clementy J, Danilovic D, Hindricks G (2008) Automatic home monitoring of implantable cardioverter defibrillators. Europace 10:729–735PubMedCrossRef Nielsen JC, Kottkamp H, Zabel M, Aliot E, Kreutzer U, Bauer A, Schuchert A, Neuser H, Schumacher B, Schmidinger H, Stix G, Clementy J, Danilovic D, Hindricks G (2008) Automatic home monitoring of implantable cardioverter defibrillators. Europace 10:729–735PubMedCrossRef
20.
Zurück zum Zitat Abraham WT, Compton S, Haas G, Foreman B, Canby RC, Fishel R, McRae S, Toledo GB, Sarkar S, on behalf of the FAST investigators (2009) Superior performance of intrathoracic impedance-derived fluid index versus daily weight monitoring in heart failure patients: results of the Fluid Accumulation Status Trial (FAST). J Card Fail 15:813 (abstract)CrossRef Abraham WT, Compton S, Haas G, Foreman B, Canby RC, Fishel R, McRae S, Toledo GB, Sarkar S, on behalf of the FAST investigators (2009) Superior performance of intrathoracic impedance-derived fluid index versus daily weight monitoring in heart failure patients: results of the Fluid Accumulation Status Trial (FAST). J Card Fail 15:813 (abstract)CrossRef
21.
Zurück zum Zitat Santini M, Ricci RP, Lunati M, Landolina M, Perego GB, Marzegalli M, Schirru M, Belvito C, Brambilla R, Guenzati G, Gilardi S, Valsecchi S (2009) Remote monitoring of patients with biventricular defibrillators through the CareLink system improves clinical management of arrhythmias and heart failure episodes. J Interv Card Electrophysiol 24:53–61PubMedCrossRef Santini M, Ricci RP, Lunati M, Landolina M, Perego GB, Marzegalli M, Schirru M, Belvito C, Brambilla R, Guenzati G, Gilardi S, Valsecchi S (2009) Remote monitoring of patients with biventricular defibrillators through the CareLink system improves clinical management of arrhythmias and heart failure episodes. J Interv Card Electrophysiol 24:53–61PubMedCrossRef
22.
Zurück zum Zitat Conraads VM, Tavazzi L, Santini M, Oliva F, Gerritse B, Yu CM, Cowie MR (2011) Sensitivity and positive predictive value of implantable intrathoracic impedance monitoring as a predictor of heart failure hospitalizations: the SENSE-HF trial. Eur Heart J 32:2266–2273 Conraads VM, Tavazzi L, Santini M, Oliva F, Gerritse B, Yu CM, Cowie MR (2011) Sensitivity and positive predictive value of implantable intrathoracic impedance monitoring as a predictor of heart failure hospitalizations: the SENSE-HF trial. Eur Heart J 32:2266–2273
23.
Zurück zum Zitat Adamson PB, Smith AL, Abraham WT, Kleckner KJ, Stadler RW, Shih A, Rhodes MM (2004) Continuous automatic assessment in patients with symptomatic heart failure: prognostic value of heart rate variability measured by an implanted cardiac resynchronization device. Circulation 110:2389–2394PubMedCrossRef Adamson PB, Smith AL, Abraham WT, Kleckner KJ, Stadler RW, Shih A, Rhodes MM (2004) Continuous automatic assessment in patients with symptomatic heart failure: prognostic value of heart rate variability measured by an implanted cardiac resynchronization device. Circulation 110:2389–2394PubMedCrossRef
24.
Zurück zum Zitat Page E, Cazeau S, Ritter P, Galley D, Casset C (2007) Physiological approach to monitor patients in congestive heart failure: application of a new implantable device-based system to monitor daily life activity and ventilation. Europace 9:687–693PubMedCrossRef Page E, Cazeau S, Ritter P, Galley D, Casset C (2007) Physiological approach to monitor patients in congestive heart failure: application of a new implantable device-based system to monitor daily life activity and ventilation. Europace 9:687–693PubMedCrossRef
25.
Zurück zum Zitat Auricchio A, Brugada J, Ellenbogen KA, Gold MR, Leyva F (2010) Assessment of a novel device-based diagnostic algorithm to monitor patient status in moderate-to-severe heart failure: rationale and design of the CLEPSYDRA study. Eur J Heart Fail 12:1363–1371PubMedCrossRef Auricchio A, Brugada J, Ellenbogen KA, Gold MR, Leyva F (2010) Assessment of a novel device-based diagnostic algorithm to monitor patient status in moderate-to-severe heart failure: rationale and design of the CLEPSYDRA study. Eur J Heart Fail 12:1363–1371PubMedCrossRef
26.
Zurück zum Zitat Bocchiardo M, Meyer ZV, Militello C, Lippert M, Czygan G, Gaita F (2010) Intracardiac impedance monitors stroke volume in resynchronization therapy patients. Europace 12:702–707PubMedCrossRef Bocchiardo M, Meyer ZV, Militello C, Lippert M, Czygan G, Gaita F (2010) Intracardiac impedance monitors stroke volume in resynchronization therapy patients. Europace 12:702–707PubMedCrossRef
27.
Zurück zum Zitat Adamson PB, Abraham WT, Aaron M, Aranda JM Jr, Bourge RC, Smith A et al (2011) CHAMPION trial rationale and design: the long-term safety and clinical efficacy of a wireless pulmonary artery pressure monitoring system. J Card Fail 17:3–10PubMedCrossRef Adamson PB, Abraham WT, Aaron M, Aranda JM Jr, Bourge RC, Smith A et al (2011) CHAMPION trial rationale and design: the long-term safety and clinical efficacy of a wireless pulmonary artery pressure monitoring system. J Card Fail 17:3–10PubMedCrossRef
Metadaten
Titel
Remote monitoring of heart failure patients using implantable cardiac pacing devices and external sensors: results of the Insight-HF study
verfasst von
Ann Lieback
Jochen Proff
Kai Wessel
Eckart Fleck
Stephan Götze
Publikationsdatum
01.02.2012
Verlag
Springer-Verlag
Erschienen in
Clinical Research in Cardiology / Ausgabe 2/2012
Print ISSN: 1861-0684
Elektronische ISSN: 1861-0692
DOI
https://doi.org/10.1007/s00392-011-0369-1

Weitere Artikel der Ausgabe 2/2012

Clinical Research in Cardiology 2/2012 Zur Ausgabe

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

26.04.2024 Mammografie Nachrichten

Routinemäßige Mammografien helfen, Brustkrebs frühzeitig zu erkennen. Anhand der Röntgenuntersuchung lassen sich aber auch kardiovaskuläre Risikopatientinnen identifizieren. Als zuverlässiger Anhaltspunkt gilt die Verkalkung der Brustarterien.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Adipositas-Medikament auch gegen Schlafapnoe wirksam

24.04.2024 Adipositas Nachrichten

Der als Antidiabetikum sowie zum Gewichtsmanagement zugelassene Wirkstoff Tirzepatid hat in Studien bei adipösen Patienten auch schlafbezogene Atmungsstörungen deutlich reduziert, informiert der Hersteller in einer Vorab-Meldung zum Studienausgang.

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.