nach oben

Pediatric Nephrology

Erschienen in:

01.08.2011 | Educational Review

Renal amyloidosis in children

verfasst von: Yelda Bilginer, Tekin Akpolat, Seza Ozen

Erschienen in: Pediatric Nephrology | Ausgabe 8/2011

Einloggen, um Zugang zu erhalten

Abstract

Renal amyloidosis is a detrimental disease caused by the deposition of amyloid fibrils. A child with renal amyloidosis may present with proteinuria or nephrotic syndrome. Chronic renal failure may follow. Amyloid fibrils may deposit in other organs as well. The diagnosis is through the typical appearance on histopathology. Although chronic infections and chronic inflammatory diseases used to be the causes of secondary amyloidosis in children, the most frequent cause is now autoinflammatory diseases. Among this group of diseases, the most frequent one throughout the world is familial Mediterranean fever (FMF). FMF is typically characterized by attacks of clinical inflammation in the form of fever and serositis and high acute-phase reactants. Persisting inflammation in inadequately treated disease is associated with the development of secondary amyloidosis. The main treatment is colchicine. A number of other monogenic autoinflammatory diseases have also been identified. Among them cryopyrin-associated periodic syndrome (CAPS) is outstanding with its clinical features and the predilection to develop secondary amyloidosis in untreated cases. The treatment of secondary amyloidosis mainly depends on the treatment of the disease. However, a number of new treatments for amyloid per se are in the pipeline.

Nur mit Berechtigung zugänglich

Perfetto F, Moggi-Pignone A, Livi R, Tempestini A, Bergesio F, Matucci-Cerinic M (2010) Systemic amyloidosis: a challenge for the rheumatologist. Nat Rev Rheumatol 6:417–429PubMed

Röcken C, Shakespeare A (2002) Pathology, diagnosis and pathogenesis of AA amyloidosis. Virchows Arch 440:111–122PubMed

Picken MM (2007) New insights into systemic amyloidosis: the importance of diagnosis of specific type. Curr Opin Nephrol Hypertens 16:196–203PubMed

Rysavá R (2007) AL amyloidosis with renal involvement. Kidney Blood Press Res 30:359–364PubMed

Drüeke TB, Massy ZA (2009) Beta2-microglobulin. Semin Dial 22:378–380PubMed

Lachmann HJ, Booth DR, Booth SE, Bybee A, Gilbertson JA, Gillmore JD, Pepys MB, Hawkins PN (2002) Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis. N Engl J Med 6(346):1786–1791

Westermark P, Bergström J, Solomon A, Murphy C, Sletten K (2003)Transthyretin-derived senile systemic amyloidosis: clinicopathologic and structural considerations. Amyloid 10 Suppl 1:48-54

Ozen S (2004) Renal amyloidosis in familial Mediterranean fever. Kidney Int 65:1118–1127PubMed

Falk RH, Comenzo RL, Skinner M (1997) The systemic amyloidoses. N Engl J Med 337:898–909PubMed

10.

Ben Chetritt R (2003) FMF and renal amyloidosis. Phenotype- genotype correlation, treatment and prognosis. J Nephrol 16:431–434

11.

Tunca M, Akar S, Onen F, Ozdogan H, Kasapcopur O, Yalcınkaya F, Tutar E, Ozen S, Topaloglu R, Yılmaz E, Arici N, Bakkaloglu A, Besbas N, Akpolat T, Dinc A, Erken E; Turkish FMF study group (2005) Familial Mediterranean fever in Turkey. Results of a nationwide multicenter study. Medicine 84:1-11

12.

Tuglular S, Yalcinkaya F, Paydas S, Oner A, Utas C, Bozfakioglu S, Ataman R, Akpolat T, Ok E, Sen S, Düsünsel R, Evrenkaya R, Akoglu E (2002) A retrospective analysis for aetiology and clinical findings of 287 secondary amyloidosis cases in Turkey. Nephrol Dial Transplant 17:2003–2005PubMed

13.

Uda H, Yokota A, Kobayashi K, Miyake T, Fushimi H, Maeda A, Saiki O (2006) Two distinct clinical courses of renal involvement in rheumatoid patients with AA amyloidosis. J Rheumatol 33:1482–1487PubMed

14.

Nishi S, Alchi B, Imai N, Gejyo F (2008) New advances in renal amyloidosis. Clin Exp Nephrol 12:93–101PubMed

15.

Neugarten J, Gallo GR, Buxbaum J, Katz LA, Rubenstein J, Baldwin DS (1986) Amyloidosis in subcutaneous heroin abusers ("skin poppers' amyloidosis"). Am J Med 81:635–640PubMed

16.

Orfila C, Lepert JC, Modesto A, Bernadet P, Suc JM (1991) Fanconi's syndrome, kappa light-chain myeloma, non-amyloid fibrils and cytoplasmic crystals in renal tubular epithelium. Am J Nephrol 11:345–349PubMed

17.

Dubrey SW, Cha K, Simms RW, Skinner M, Falk RH (1996) Electrocardiography and Doppler echocardiography in secondary (AA) amyloidosis. Am J Cardiol 77:313–315PubMed

18.

Dubrey SW, Cha K, Anderson J, Chamarthi B, Reisinger J, Skinner M, Falk RH (1998) The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement. QJM 91:141–157PubMed

19.

Benson MD (2003) The hereditary amyloidoses. Best Pract Res Clin Rheumatol 17:909–927PubMed

20.

Sattianayagam P, Hawkins P, Gillmore J (2009) Amyloid and the GI tract. Expert Rev Gastroenterol Hepatol 3:615–630PubMed

21.

Ebert EC, Nagar M (2008) Gastrointestinal manifestations of amyloidosis. Am J Gastroenterol 103:776–787PubMed

22.

Chopra S, Rubinow A, Koff RS, Cohen AS (1984) Hepatic amyloidosis. A histopathologic analysis of primary (AL) and secondary (AA) forms. Am J Pathol 115:186–193PubMedPubMedCentral

23.

Looi LM, Sumithran E (1988) Morphologic differences in the pattern of liver infiltration between systemic AL and AA amyloidosis. Hum Pathol 19:732–735PubMed

24.

Renzulli P, Schoepfer A, Mueller E, Candinas D (2009) Atraumatic splenic rupture in amyloidosis. Amyloid 16:47–53PubMed

25.

Elvy A, Harbach L, Bhangu A (2010) Atraumatic splenic rupture: a 6-year case series. Eur J Emerg Med. doi:https://doi.org/10.1097/MEJ.0b013e32833ddeb5

26.

Renzulli P, Schoepfer A, Mueller E, Candinas D (2009) Atraumatic splenic rupture in amyloidosis. Amyloid 16:47–53PubMed

27.

Sungur C, Sungur A, Ruacan S, Arik N, Yasavul U, Turgan C, Caglar S (1993) Diagnostic value of bone marrow biopsy in patients with renal disease secondary to familial Mediterranean fever. Kidney Int 44:834–836PubMed

28.

Sucker C, Hetzel GR, Grabensee B, Stockschlaeder M, Scharf RE (2006) Amyloidosis and bleeding: pathophysiology, diagnosis, and therapy. Am J Kidney Dis 47:947–955PubMed

29.

Zangari M, Elice F, Fink L, Tricot G (2007) Hemostatic dysfunction in paraproteinemias and amyloidosis. Semin Thromb Hemost 33:339–349PubMed

30.

Benson MD, Kincaid JC (2007) The molecular biology and clinical features of amyloid neuropathy. Muscle Nerve 36:411–423PubMed

31.

Keven K, Oztas E, Aksoy H, Duman N, Erbay B, Ertürk S (2001) Polyglandular endocrine failure in a patient with amyloidosis secondary to familial Mediterranean fever. Am J Kidney Dis 38:E39PubMed

32.

Herrera GA, Turbat-Herrera EA (2010) Renal diseases with organized deposits: an algorithmic approach to classification and clinicopathologic diagnosis. Arch Pathol Lab Med 134:512–531PubMed

33.

Sen S, Sarsik B (2010) A proposed histopathologic classification, scoring, and grading system for renal amyloidosis: standardization of renal amyloid biopsy report. Arch Pathol Lab Med 134:532–544PubMed

34.

Hawkins PN (2002) Serum amyloid P component scintigraphy for diagnosing and monitoring amyloidosis. Curr Opin Nephrol Hypertens 11:649–655PubMed

35.

Petty RE, Soutwood TR, Manners P, Baum J, Glass DN, Goldenberg J, He X, Maldonado-Cocco J, Orozco-Alcala J, Prieur A, Suarez Almazor ME, Woo P (2004) International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 31:390–392PubMed

36.

Besbas N, Saatci U, Bakkaloğlu A, Ozen S (1992) Amyloidosis of juvenile chronic arthritis in Turkish children. Scand J Rheumatol 21:257–259PubMed

37.

Stojanov S, Kastner DL (2005) Familial autoinflammatory diseases: genetics, pathogenesis and treatment. Curr Opin Rheumatol 17:586–599PubMed

38.

Masters SL, Simon A, Ksentijevic I, Kastner DL (2009) Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease. Annu Rev Immunol 27:621–628PubMedPubMedCentral

39.

Ozen S, Karaaslan Y, Ozdemir O, Saatci U, Bakkaloglu A, Koroglu E, Tezcan S (1998) Prevalence of juvenile chronic arthritis and familial Mediterranean fever in Turkey. J Rheumatol 25:2445–2449PubMed

40.

Sohar E, Gafni J, Pras M, Heller H (1967) Familial Mediterranean fever. A survey of 470 cases and review of literature. Am J Med 43:227–253PubMed

41.

Majeed HA, El-Shanti H, Al-Khateeb MS, Rabia ZA (2002) Genotype/phenotype correlations in Arab patients with FMF. Semin Arthritis Rheum 31:371–376PubMed

42.

Chae JJ, Wood G, Richard K, Jaffe H, Colburn NT, Masters SL, Gumucio DL, Shoham NG, Kastner DL (2008) The familial Mediterranean fever protein, pyrin is cleaved by caspase-1 and activates NF-kappa B through its N-terminal fragment. Blood 11:1794–1803

43.

Samuels J, Ozen S (2006) Familial Mediterranean fever and the other auto inflammatory syndromes: evaluation of the patient with recurrent fever. Curr Opin Rheumatol 18:108–117PubMed

44.

International FMF Consortium (1997) Ancient missense mutations in a new number of the Roret gene family are likely to cause FMF. Cell 90:797–807

45.

French FMF consortium (1997) A candidate gene for familial Mediterranean fever. Nat Genet 17:25–31

46.

Ozen S, Balci B, Ozkara S, Ozcan A, Yilmaz E, Besbas N, Ozguc M, Kastner DL, Bakkaloglu A (2002) Is there a heterozygote advantage for familial Mediterranean fever carriers against tuberculous infections? Clin Exp Rheumatol 20:S57–S58PubMed

47.

Ozen S (2009) Mutations/polymorphisms in a monogenic auto inflammatory disease is a susceptibility marker for certain rheumatic diseases. Lessons from the bedside for the benchside. Curr Opin Rheumatol 27:S29–S31

48.

Booth DR, Lachman JJ, Gillmor JD, Booth SE, Hawkins PN (2002) Prevalence and significance of the familial Mediterranean gene mutation encoding pyrin Q148. QJM 95:332–333

49.

Touitou I, Sarkisian T, Medlej-Hashim M, Tunca M, Livneh A, Cattan D, Yalcınkaya F, Ozen S, Majeed H, Ozdogan H, Kastner D, Booth D, Ben-Chetrit E, Pugnere D, Michelon C, Seguret F, Gershoni-Baruch R (2007) Country as the primary risk factor for renal amyloidosis in familial Mediterranean fever. Arthritis Rheum 56:1706–1712PubMed

50.

Ozen S, Aktay N, Lainka E, Duzova A, Bakkaloglu A, Kallinich T (2009) Disease severity in children and adolescents with familial Mediterranean fever: a comparative study to explore environmental effects on a monogenic disease. Ann Rheum Dis 68:246–248PubMed

51.

Ben Chetrit E, Levy M (1998) Familial Mediterranean fever. Lancet 351:659–664PubMed

52.

Lidar M, Livneh A (2007) Familial Mediterranean fever: clinical, molecular and management advances. Neth J Med 65:318–324PubMed

53.

Ozen S (2010) The "other" vasculitis syndromes and kidney involvement. Pediatr Nephrol 25:1633–1639PubMed

54.

Lachmann HJ, Sengul B, Yavuzsen TU, Booth DR, Booth SE, Bybee A, Gallimore JR, Soytürk M, Akar S, Tunca M, Hawkins PN (2006) Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. Rheumatology 45:746–750PubMed

55.

Zemer D, Pras M, Sohar E, et Modan M, Cabili S, Gafni J (1986) Colchicine in the prevention and treatment of amyloidosis of familial Mediterranean fever. N Engl J Med 314:1001–1005PubMed

56.

Saatci U, Ozen S, Ozdemir S, Bakkaloglu A, Besbas N, Topaloglu R, Arslan S (1997) FMF in children: report of a large series and discussions of the risk and prognostic factors of amyloidosis. Eur J Pediatr 156:619–623PubMed

57.

Sohar E, Gafni J, Pras M, Heller H (1967) Familial Mediterranean fever. A survey of 470 cases and review of literature. Am J Med 43:227–253PubMed

58.

Shohat M, Magal N, Shohat T, Chen X, Dagan T, Mimouni A, Danon Y, Laron R, Ogur G, Schlezinger M, Halpern GJ, Schwabe A, Kastner D, Rotter JI, Fischel-Ghodslan N (1999) Phenotype-genotype correlation in FMF: evidence for an association between M694V and amyloidosis. Eur J Hum Genet 7:287–292PubMed

59.

Cakar N, Yalcınkaya F, Ozkaya N, Tekin M, Akar N, Koçak H, Mısırlıoğlu M, Akar E, Tümer N (2001) FMF associated amyloidosis in childhood. Clinical features, course and outcome. Clin Exp Rheumatol 19:S63–S67PubMed

60.

Cazeneuve C, Ajrapetyan H, Papin S, Rpudot-Thoraval F, Genevieve D, Mindjoyan E, Papazian M, Sarkisian A, Babloyan A, Boissier B, Duquesnay P, Kouyoumdjian JC, Girodon-Boulandet E, Grateau G, Sarkisian T, Amselem S (2000) Identification of MEFV independent modifying genetic factors for FMF. Am J Hum Genet 67:1136–1143PubMedPubMedCentral

61.

Gershoni-Baruch R, Brik R, Zacks N, Shinawi M, Lidar M, Livneh A (2003) The contribution of genotypes at the MEFV and SAA1 loci to amyloidosis and disease severity in patients with FMF. Arthritis Rheum 48:1149–1155PubMed

62.

Ozen S, Ben-Chetrit E, Bakkaloglu A, Gur H, Tınaztepe K, Calguneri M, Turgan C, Turkman A, Akpolat I, Danaci M, Besbas N, Akpolat T (2001) Polyarteritis nodosa in patients with FMF: a concomitant disease or a feature of FMF? Semin Arthritis Rheum 30:281–287PubMed

63.

Goldinger SE (1972) Colchicine for familial Mediterranean fever. N Engl J Med 287:1302

64.

Kallinich T, Haffner D, Niehues T, Huss K, Lainka E, Neudorf U, Schaefer C, Stajanov S, Timmann C, Keitzer R, Ozdogan H, Ozen S (2007) Colchicine use in children and adolescents with familial Mediterranean fever: literature review and consensus statement. Pediatrics 119:e474–e483PubMed

65.

Oner A, Erdogan O, Demircin G, Bulbul M, Memis L (2003) Efficacy of colchicine therapy in amyloid nephropathy of familial Mediterranean fever. Pediatr Nephrol 18:521–526PubMed

66.

Livneh A, Zemer D, Langevitz P, Laor A, Sohar E, Pras M (1994) Colchicine treatment of AA amyloidosis of familial Mediterranean fever: an analysis of factors affecting outcome. Arthritis Rheum 37:1804–1811PubMed

67.

Schattner A (1991) Colchicine-expanding horizons. Postgrad Med J 67:223–226PubMedPubMedCentral

68.

Bohle A, Wehrmann M, Fissele R, Gise HV, Mackensen-Haen S, Müller C (1993) The long-term prognosis of AA and al amyloidosis and the pathogenesis of chronic renal failure in renal amyloidosis. Pathol Res Pract 89:316–331

69.

Bauer EZ, Valle KJ (1982) Colchicine-induced modulation of collagenase in human skin fibroblast cultures. Stimulation enzyme synthesis normal cells. J Invest Dermatol 79:398–402PubMed

70.

Montseny JJ, Meyrier A, Gherardi RK (1996) Colchicine toxicity in patients with chronic renal failure. Nephrol Dial Transplant 11:2055–2058PubMed

71.

Wallace SL, Singer JZ, Duncan GJ, Wigley FM, Kunel RW (1991) Renal function predicts colchicine toxicity: guidelines for the prophylactic use of colchicine in gout. J Rheumatol 18:264–269PubMed

72.

Anderson-Haag T, Patel B (2003) Safety of colchicine in dialysis patients. Semin Dial 16:412–413PubMed

73.

Hoffmann HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD (2001) Mutation of a new gene encoding a putative pyrin like protein causes familial cold autoinflammatory syndrome and Muckle Wells syndrome. Nat Genet 29:301–305

74.

Feldmann J, Prieur AM, Quartier P, Berquin P, Certain S, Cortis E, Teilac-Hamel D, Fischer A, de Saint BG (2002) Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. Am J Hum Genet 71:198–203PubMedPubMedCentral

75.

Hoffman HM, Wanderer AA, Broide DH (2001) Familial cold autoinflammatory syndrome: phenotype and genotype of an autosomal dominant periodic fever. J Allergy Clin Immunol 108:615–620PubMedPubMedCentral

76.

Toker O, Hashkes PJ (2010) Critical appraisal of canakinumab in the treatment of adults and children with cryopyrin-associated periodic syndrome (CAPS). Biologics 25:131–138

77.

Hawkins PN, Lachmann HJ, Aganna E, McDermott MF (2004) Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra. Arthritis Rheum 50:607–612PubMed

78.

Lachmann HJ, Kone-Paut I, Kuemmerle-Deschner JB, Leslie KS, Hachulla E, Quartier P, Gitton X, Widmer A, Patel N, Hawkins PN (2009) Use of canakinumab in the cryopyrin associated periodic syndrome. N Engl J Med 360:2416–2425PubMed

79.

Drenth JP, Cuisset L, Grateau G, Vasseur C, van de Velde-Visser SD, de Jong JG, Beckmann JS, van der Meer JW, Delpech M (1999) Mutations in the gene encoding mevolanate kinase cause hyper-IgD and periodic fever syndrome. Nat Genet 22:178–181PubMed

80.

Goldbach-Mansky R, Kastner DL (2009) Autoinflammation: the prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses. J Allergy Clin Immunol 124:1141–1149PubMedPubMedCentral

81.

McDermott MF, Aksentijevich I, Galon J, McDermott EM, Ogunkolade BW, Centola M, Mansfield E, Godina M, Karenko L, Petterson T, McCarthy J, Frucht DM, Aringer M, Torosyan Y, Teppo AM, Wilson M, Karaaslan HM, Wan Y, Todd I, Wood G, Schlimgen R, Kumarajeewa TR, Cooper SM, Vella JP, Amos EI, Mulley J, Quane KA, Mollay MG, Ranki A, Powell RJ, Hitman GA, Shea JJ O, Kastner DL (1999) Germline mutations in the extracellular domains of the 55-kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell 97:133–144PubMed

82.

Hull KM, Drewe E, Aksentijevich I, Singh HK, Wong K, McDermott EM, Dean J, Powell RJ, Kastner DL (2002) The TNF receptor–associated periodic syndrome (TRAPS): emerging concepts of an auto inflammatory disorder. Medicine 81:349–368PubMed

83.

Aksentijevich I, Galon J, Soares M, Mansfield E, Hull K, Oh HH, Goldbach-Mansky R, Dean J, Athreya B, Regianato AJ, Henrickson M, Pons-Estel B, O’Shea JJ, Kastner DL (2001) The tumor necrosis factor receptor associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype-phenotype studies, and evidence for further heterogeneity of periodic fevers. Am J Hum Genet 69:301–314PubMedPubMedCentral

84.

Reddy P, Slack JL, Davis R, Cerretti DP, Kozlosky CJ, Blanton RA, Shows D, Peschon JJ, Black RA (2000) Functional analysis of the domain structure of tumor necrosis factor–alpha converting enzyme. J Biol Chem 275:14608–14614PubMed

85.

Toro JR, Aksentijevich I, Hull K, Dean J, Kastner DL (2000) Tumor necrosis factor receptor associated periodic syndrome: a novel syndrome with cutaneous manifestations. Arch Dermatol 136:1487–1494PubMed

86.

Gottorno M, Pelagatti MA, Meini A, Obici L, Barcellona R, Federici S, Buoncompagni A, Plebani A, Merlini G, Martini A (2008) Persistent efficacy of anakinra in patients with tumor necrosis factor receptor associated periodic syndrome. Arthritis Rheum 58:1516–1520

87.

Akpolat T, Akkoyunlu M, Akpolat I, Dilek M, Odabas AR, Ozen S (2002) Renal Behçet’s disease: a cumulative analysis. Semin Arthritis Rheum 31:317–337PubMed

88.

Penza R, Brunetti L, Francioso G, Tricarico A, Lospalluti M (1983) Renal amyloidosis in a child with Behçet's syndrome. Int J Pediatr Nephrol 4:35–37PubMed

89.

Kaltenis P, Mudeniené V, Maknavicius S, Seinin D (2008) Renal amyloidosis in a child with chronic granulomatous disease and invasive aspergillosis. Pediatr Nephrol 23:831–834PubMed

90.

Simşek B, Bayazit AK, Ergin M, Soran M, Dursun H, Kilinc Y (2006) Renal amyloidosis in a child with sickle cell anemia. Pediatr Nephrol 21:877–879PubMed

91.

Büyükpamukçu M, Hazar V, Tinaztepe K, Bakkaloğlu A, Akyüz C, Kutluk T (2000) Hodgkin's disease and renal paraneoplastic syndromes in childhood. Turk J Pediatr 42:109–114PubMed

92.

Kyle RA, Rajkumar SV (2007) Epidemiology of the plasma-cell disorders. Best Pract Res Clin Haematol 20:637–664PubMed

93.

Mor A, Pillinger MH, Kishimoto M, Abeles AM, Livneh A (2007) Familial Mediterranean fever successfully treated with etanercept. J Clin Rheumatol 13:38–40PubMed

94.

Gottenberg JE, Merle-Vincent F, Bentaberry F, Allanore Y, Berenbaum F, Fautrel B, Combe B, Durbach A, Sibilia J, Dougados M, Mariette X (2003) Anti-tumor necrosis factor alpha therapy in fifteen patients with AA amyloidoses secondary to inflammatory arthritis. Arthritis Rheum 48:2019–2024PubMed

95.

Ozen S, Bilginer Y, Ayaz NA, Calguneri M (2010) Anti IL1 treatment for FMF patients resistant to colchicines: reasoning treatment from laboratory experience. J Rheumatol. doi:https://doi.org/10.3899/jrheumatol.100718

96.

Bilginer Y, Ayaz NA, Ozen S (2009) Anti-IL-1 treatment for secondary amyloidosis in an adolescent with FMF and Behçet's disease. Clin Rheumatol 29:209–210PubMed

97.

Dember LM (2009) Modern treatment of amyloidosis: unresolved questions. J Am Soc Nephrol 20:469–472PubMed

98.

Sekijima Y, Kelly JW, Ikeda S (2008) Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses. Curr Pharm Des 14:3219–3230PubMed

99.

Dember LM, Hawkins PN, Hazenberg BP, Gorevic PD, Merlini G, Butrimiene I, Livneh A, Lesnyak O, Puéchal X, Lachmann HJ, Obici L, Balshaw R, Garceau D, Hauck W, Skinner M (2007) Eprodisate for AA Amyloidosis Trial Group. Eprodisate for the treatment of renal disease in AA amyloidosis. N Engl J Med 356:2349–2360PubMed

100.

Rysavá R, Merta M, Spicka I, Tesar V (2003) Current therapeutic possibilities in primary and secondary amyloidosis and our experience with 31 patients. Nephrol Dial Transplant 18(Suppl 5):v38–v40PubMed

101.

Keven K, Sengul S, Kutlay S, Ekmekci Y, Anadol E, Nergizoglu G, Ates K, Erturk S, Erbay B (2004) Long-term outcome of renal transplantation in patients with familial Mediterranean fever amyloidosis: a single-center experience. Transplant Proc 36:2632–2634PubMed

102.

Altiparmak MR, Pamuk ON, Ataman R, Serdengeçti K (2004) Continuous ambulatory peritoneal dialysis in familial Mediterranean fever amyloidosis patients with end-stage renal failure: a single-centre experience from Turkey. Nephron Clin Pract 98:c119–c123PubMed

103.

Ari JB, Zlotnik M, Oren A, Berlyne GM (1976) Dialysis in renal failure caused by amyloidosis of familial Mediterranean fever. A report of ten cases. Arch Intern Med 136:449–451PubMed

104.

Sahin S, Sahin GM, Ergin H, Kantarci G (2007) The effect of dialytic modalities on clinical outcomes in ESRD patients with familial Mediterranean fever. Ren Fail 29:315–319PubMed

105.

Tan SY, Irish A, Winearls CG, Brown EA, Gower PE, Clutterbuck EJ, Madhoo S, Lavender JP, Pepys MB, Hawkins PN (1996) Long-term effect of renal transplantation on dialysis-related amyloid deposits and symptomatology. Kidney Int 50:282–289PubMed

106.

Gillmore JD, Lachmann HJ, Rowczenio D, Gilbertson JA, Zeng CH, Liu ZH, Li LS, Wechalekar A, Hawkins PN (2009) Diagnosis, pathogenesis, treatment, and prognosis of hereditary fibrinogen A alpha-chain amyloidosis. J Am Soc Nephrol 20:444–451PubMedPubMedCentral

107.

Saglam F, Celik A, Cavdar C, Sifil A, Atila K, Kaya GC, Bora S, Gulay H, Camsari T (2008) A renal transplant recipient with delayed gastric emptying in amyloidosis due to familial Mediterranean fever improved with erythromycin: a case report. Transplant Proc 40:308–309PubMed

108.

Terkeltaub RA (2009) Colchicine update: 2008. Semin Arthritis Rheum 38:411–419PubMed

109.

Tweezer-Zaks N, Rabinovich E, Lidar M, Livneh A (2008) Interferon-alpha as a treatment modality for colchicine-resistant familial Mediterranean fever. J Rheumatol 35:1362–1365PubMed

110.

Fabrizi F, Messa P, Basile C, Martin P (2010) Hepatic disorders in chronic kidney disease. Nat Rev Nephrol 6:395–403PubMed

111.

Moser C, Pohl G, Haslinger I, Knapp S, Rowczenio D, Russel T, Lachmann HJ, Lang U, Kovarik J (2009) Successful treatment of familial Mediterranean fever with Anakinra and outcome after renal transplantation. Nephrol Dial Transplant 24:676–678PubMed

Titel: Renal amyloidosis in children
verfasst von: Yelda Bilginer
Tekin Akpolat
Seza Ozen
Publikationsdatum: 01.08.2011
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 8/2011
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-011-1797-x

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Renal amyloidosis in children

Abstract

Neu im Fachgebiet Pädiatrie

Kinder mit anhaltender Sinusitis profitieren häufig von Antibiotika

Neuer Typ-1-Diabetes bei Kindern am Wochenende eher übersehen

Neue Studienergebnisse zur Myopiekontrolle mit Atropin

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Update Pädiatrie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 8/2011

Cystic diseases of the kidney: ciliary dysfunction and cystogenic mechanisms

Effect of diet, enalapril, or losartan in post-diarrheal hemolytic uremic syndrome nephropathy

Nephrotic syndrome in The Netherlands: a population-based cohort study and a review of the literature

Urinary MMP-9/NGAL complex in children with acute cystitis

Diffusion-weighted MRI of exercise-induced acute renal failure (ALPE)

Hepatoblastoma and prune belly syndrome: a potential association

Neu im Fachgebiet Pädiatrie

Kinder mit anhaltender Sinusitis profitieren häufig von Antibiotika

Neuer Typ-1-Diabetes bei Kindern am Wochenende eher übersehen

Neue Studienergebnisse zur Myopiekontrolle mit Atropin

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Update Pädiatrie