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Graefe's Archive for Clinical and Experimental Ophthalmology

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01.07.2015 | Neurophthalmology

Retinal nerve fiber layer structure abnormalities in patients with Neuro-Behcet's disease

verfasst von: Didar Ucar, Ugur Uygunoglu, Funda Dikkaya, Yeliz Yıldırım, Cansu Yuksel-Elgin, Sabahattin Saip, Aksel Siva, Yilmaz Ozyazgan

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 7/2015

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Abstract

Purpose

Our aim was the evaluation of retinal nerve fiber layer (RNFL) and central macular thickness (CMT) in patients with Neuro-Behcet's disease (NBD) and to compare the results with healthy control subjects.

Methods

We recruited 50 eyes of 25 patients with NBD and 42 eyes of 21 age-matched healthy control subjects. Patients and control subjects underwent a thorough ophthalmic examination, including retinal nerve fiber layer and macular thickness measurements by optical coherence tomography.

Results

No significant difference was found between groups for age, sex, intra-ocular pressure and central corneal thickness measurements. The average RNFL in patients with NBD was significantly lower than that of healthy controls (86.92 ± 18.36 μm vs. 99.74 ± 8.73 μm; p = 0.00). There was significant thinning of the RNFL in three of four quadrants of the peripapillary area, superior (107.22 ± 30.91 μm vs. 125.57 ± 20.97 μm; p = 0.00), inferior (110.36 ± 25.57 μm vs. 132.19 ± 12.71 μm; p = 0.00) and nasal (68.84 ± 18.47 μm vs. 74.98 ± 11.42 μm; p = 0.05), in patients with NBD. Average CMT was significantly lower in NBD patients than in control subjects (244.06 ± 26.25 μm vs. 261.69 ± 25.71 μm; p = 0.00).

Conclusions

There are significant differences in average RNFL and CMT between the two groups. RNFL and CMT thicknesses are reduced in patients with NBD compared with the healthy controls.

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Titel: Retinal nerve fiber layer structure abnormalities in patients with Neuro-Behcet's disease
verfasst von: Didar Ucar
Ugur Uygunoglu
Funda Dikkaya
Yeliz Yıldırım
Cansu Yuksel-Elgin
Sabahattin Saip
Aksel Siva
Yilmaz Ozyazgan
Publikationsdatum: 01.07.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 7/2015
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-015-3040-0

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Retinal nerve fiber layer structure abnormalities in patients with Neuro-Behcet's disease

Abstract

Purpose

Methods

Results

Conclusions

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