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Erschienen in:
01.05.2015 | General Gynecology
RETRACTED ARTICLE: Therapeutic effects of metformin and laparoscopic ovarian drilling in treatment of clomiphene and insulin-resistant polycystic ovary syndrome
Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 5/2015
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Objective
To compare the therapeutic effects of metformin (Met) and laparoscopic ovarian
drilling (LOD) in clomiphene and insulin-resistant patients with polycystic
ovary syndrome (CIRPCOS).
Methods
A total of 110 patients were randomly divided into two groups. One group was
administered Met (n = 55), while the other
group underwent LOD (n = 55). Rates of
ovulation, pregnancy, and abortion were compared between both groups.
Results
Rates of normal menstruation, ovulation, and pregnancy in the LOD group were
higher than in the Met group: 76.4 % (42/55) vs. 58.2 % (32/55), P < 0.04; 50.8 % (11/258) vs. 33.5 % (94/281),
P < 0.001; 38.2 % (21/55) vs. 20.0 %
(11/55), P < 0.03. The difference in the
early abortion rate between both groups was not statistically
significant.
Conclusions
Although Met can significantly improve a patient’s insulin resistance, we
found that in patients diagnosed with CIRCPOS, LOD can be much more effective in
improving rates of normal menstruation, ovulation, and pregnancy.