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Pediatric Cardiology

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14.06.2022 | Case Report

Reversal of Fetal Heart Block in Antibody-Positive Mother After Hydroxychloroquine and Dexamethasone

verfasst von: Mehar Hoda, William Scott, Kavita Sharma, Elaine Duryea, Catherine Ikemba

Erschienen in: Pediatric Cardiology | Ausgabe 3/2023

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Abstract

Maternal autoantibody-related complete heart block in the fetus is considered irreversible. During prenatal care for a 25-year-old nulliparous Hispanic woman with newly diagnosed nephrotic-range proteinuria and positive anti-nuclear antigen antibody, complete fetal heart block with a ventricular rate of 60 beats per minute was detected on a fetal echocardiogram at 28-week gestation. A small pericardial effusion and ascites were noted consistent with fetal hydrops. Dexamethasone and hydroxychloroquine were initiated. Fetal rhythm improved to Mobitz type 1 second-degree heart block, with a ventricular rate of 91 beats per minute. The fetus was born prematurely at 34-week gestation with second-degree heart block which improved to first-degree heart block prior to hospital discharge. First-degree heart block persisted at 2 years of age with a P-R interval of 185 ms. Transplacental treatment with dexamethasone and hydroxychloroquine was associated with sustained reversal of complete heart block to sinus rhythm.

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Titel: Reversal of Fetal Heart Block in Antibody-Positive Mother After Hydroxychloroquine and Dexamethasone
verfasst von: Mehar Hoda
William Scott
Kavita Sharma
Elaine Duryea
Catherine Ikemba
Publikationsdatum: 14.06.2022
Verlag: Springer US
Erschienen in: Pediatric Cardiology / Ausgabe 3/2023
Print ISSN: 0172-0643
Elektronische ISSN: 1432-1971
DOI: https://doi.org/10.1007/s00246-022-02945-6

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