Background
Methods
Study area
Data sources and variables
Definition of variables
MDR- TB diagnosis in Hunan province
Data analysis
Results
Variables | Frequency (%) |
---|---|
Gender | |
Female | 326 (26.1) |
Male | 922 (73.9) |
Age | |
< 15 | 26 (2.1) |
15–24 | 174 (13.9) |
25–44 | 277 (22.2) |
45–64 | 506 (40.6) |
> = 65 | 265 (21.2) |
Year of diagnosis | |
2013 | 44 (3.5) |
2014 | 63 (5.1) |
2015 | 186 (14.9) |
2016 | 301 (24.1) |
2017 | 271 (21.7) |
2018 | 383 (30.7) |
Current address | |
Hong Kong, Macau, and Taiwan | 37 (3.0) |
From Hunan, but outside Changsha | 1,151 (92.2) |
From another province of mainland China | 53 (4.3) |
From Changsha | 7 (0.5) |
Occupation | |
Children and students | 42 (3.4) |
Government employees | 23 (1.8) |
Farmers | 990 (79.3) |
Housekeepers | 89 (7.1) |
Privately employee | 19 (1.5) |
Retired | 58 (4.7) |
Othersa | 27 (2.2) |
Ethnicity | |
Han | 1,149 (92.0) |
Dong | 11 (0.9) |
Miao | 22 (1.8) |
Tujia | 54 (4.3) |
Yao | 7 (0.6) |
Othersb | 5 (0.40) |
Patient source | |
Health check | 11 (0.9) |
Recommended for consultation due to symptoms | 11 (0.9) |
Referral | 393 (31.5) |
Seeking consultation due to symptoms | 385 (30.9) |
Identified through contact tracing | 448 (35.8) |
Detainees | |
No | 1,242 (99.5) |
Yes | 6 (0.5) |
Treatment category | |
New treatment | 1,037 (83.1) |
Retreatment | 211 (16.9) |
1st diagnosis institution type | |
Communicable disease control | 998 (80.7) |
General hospital | 224 (18.1) |
Specialist hospital | 1 (0.1) |
TB dispensary | 14 (1.1) |
Severely ill | |
No | 1,197 (95.9) |
Yes | 51 (4.1) |
Median time to diagnosis and treatment interval among multidrug-resistant tuberculosis patients
Variables | Frequency (%) | Median time to diagnosis in days (IQR) | Median time to treatment in days (IQR) |
---|---|---|---|
Gender | |||
Female | 326 (26.1) | 30 (8–68) | 1 (0–17) |
Male | 922 (73.9) | 26 (6–65) | 1 (0–25) |
Year of diagnosis | |||
2013 | 44 (3.5) | 23.5 (10–49) | 0 (0–3) |
2014 | 63(5.1) | 28 (6–65) | 1 (0–7) |
2015 | 186 (14.9) | 26 (7–77) | 1 (0–23) |
2016 | 301 (24.1) | 29 (8–62) | 1 (0–19) |
2017 | 271 (21.7) | 29 (6–70) | 1 (0–20) |
2018 | 383 (30.7) | 26 (4–65) | 3 (0–31) |
Current address | |||
Foreign nationality | 37 (3.0) | 31 (9–75) | 10 (10–37) |
Hunan province | 1,151 (92.2) | 26 (6–66) | 1 (0–20) |
Another province | 60 (4.8) | 39 (13–64) | 8 (0–37) |
Occupation | |||
Child and students | 42 (3.4) | 12.5 (1–32) | 4.5 (0–24) |
Government employees | 23 (1.8) | 30 (1–53) | 8 (0–19) |
Farmers | 990 (79.3) | 29 (7–67) | 1 (0–20) |
Housekeepers | 89 (7.1) | 22 (6–60) | 5 (0–26) |
Privately employed | 19 (1.5) | 22 (1–91) | 23 (0–61) |
Retired | 58 (4.7) | 24.5 (4–81) | 12 (1–38) |
Othersa | 27 (2.2) | 37 (10–75) | 0 (0–37) |
Ethnicity | |||
Han | 1,149 (92.1) | 27 (7–65) | 1 (0–26) |
Dong | 11 (0.9) | 44 (21–291) | 1 (0–3) |
Miao | 22 (1.8) | 36 (12–96) | 3.5 (0–16) |
Tujia | 54 (4.2) | 27.5 (3–77) | 1 (0–5) |
Yao | 7 (0.6) | 14 (4–42) | 1 (0–3) |
Othersb | 5 (0.4) | 10 (9–12) | 17 (1–50) |
Patient source | |||
Health check | 11 (0.9) | 3 (0–10) | 5 (0–18) |
Recommended for consultation due to symptoms | 11(0.9) | 34 (10–60) | 0 (0–4) |
Referral | 393 (31.5) | 22 (3–65) | 2 (0–16) |
Seeking consultation due to symptoms | 385 (30.9) | 30 (13–69) | 0 (0–1) |
Identified through contact tracing | 440 (35.8) | 27.5 (5–66) | 19 (0–42.5) |
Detainees | |||
No | 1,242 (99.5) | 27 (7–66) | 1 (0–24) |
Yes | 6 (0.5) | 14 (5–35) | 13 (0–50) |
Treatment category | |||
New treatment | 1,037 (83.1) | 27 (6–63) | 1 (0–26) |
Retreatment | 211 (16.9) | 29 (12–84) | 1 (0–11) |
1st diagnosis institution type | |||
CDC | 998 (80.7) | 28 (7–65) | 1 (0–26) |
Hospital | 225 (18.2) | 24 (3–69) | 0 (0–16) |
TB dispensary | 14 (1.1) | 17 (10–38) | 3 (0–13) |
Severely ill | |||
No | 1,197 (95.9) | 27 (7–66) | 1 (0–22) |
Yes | 51 (4.1) | 31 (8–66) | 16 (0–34) |
The trend in diagnosis and treatment delay among MDR-TB patients
Factors affecting diagnosis delay among patients treated for MDR-TB
Variables | Diagnosis delay (%) | COR with a 95% CI | P-value | AOR with a 95% CI | P-value | |
---|---|---|---|---|---|---|
Yes | No | |||||
Gender | ||||||
Female | 214 | 112 | 1 | 1 | ||
Male | 570 | 352 | 0.84 (0.65–1.10) | 0.200 | 0.80 (0.61–1.05) | 0.112 |
Age in years | ||||||
< 15 | 20 | 6 | 1 | 1 | ||
15–64 | 581 | 330 | 0.53 (0.21–1.33) | 0.175 | 0.41 (0.16–1.06) | 0.066 |
≥ 65 | 183 | 128 | 0.43 (0.17–1.09) | 0.078 | 0.35 (0.14–0.91) | 0.032 |
Occupation | ||||||
Students and employed | 45 | 39 | 1 | 1 | ||
Farmers | 633 | 357 | 1.54 (0.60–1.05) | 0.060 | 1.43 (0.90–2.28) | 0.128 |
Othersa | 106 | 68 | 1.35 (0.80–2.29 | 0.262 | 1.32 (0.77–2.25) | 0.315 |
Ethnicity | ||||||
Han | 724 | 425 | 1 | 1 | ||
Other ethnic minorities | 60 | 39 | 0.90 (0.98–2.41) | 0.195 | 0.89 (0.58–1.37) | 0.184 |
Patient source | ||||||
Seeking consultations | 279 | 114 | 1 | 1 | ||
Tracing and referral | 505 | 350 | 0.59 (0.46–0.76) | 0.000 | 0.59 (0.45–0.76) | 0.000 |
Treatment category | ||||||
New treatment | 638 | 399 | 1 | 1 | ||
Retreatment | 146 | 65 | 1.40 (1.02, 1.93) | 0.036 | 1.29 (0.93–1.79) | 0.137 |
Diagnosis institution | ||||||
CDC | 635 | 365 | 1 | 1 | ||
General Hospital | 133 | 92 | 0.83 (0.62–1.11) | 0.190 | 0.85 (0.62–1.15) | 0.175 |
TB dispensary | 16 | 9 | 1.02 (0.44–2.32) | 0.969 | 0.91 (0.39–2.12) | 0.878 |
Factors affecting treatment delay among patients treated for MDR-TB
Variables | Treatment delay | COR with 95% CI | P-value | AOR with 95%CI | P-value | |
---|---|---|---|---|---|---|
Yes | No | |||||
Gender | ||||||
Female | 88 | 238 | 1 | 1 | ||
Male | 296 | 626 | 1.28 (0.96–1.69) | 0.086 | 1.22 (0.92–1.62) | 0.173 |
Ethnicity | ||||||
Han | 365 | 784 | 1 | 1 | ||
Other minorities | 19 | 80 | 0.51 (0.30–0.85) | 0.010 | 0.55 (0.33–0.93) | 0.027 |
Treatment category | ||||||
New treatment | 337 | 700 | 1 | 1 | ||
Retreatment | 47 | 164 | 0.60 (0.42–0.84) | 0.004 | 0.59 (0.42–0.85) | 0.004 |
Current residence | ||||||
Local residence | 340 | 811 | 1 | 1 | ||
Other provinces and foreign residents | 44 | 53 | 1.98 (1.30–3.01) | 0.001 | 1.99 (1.30–3.04) | 0.001 |
Severity of illness | ||||||
No | 358 | 839 | 1 | 1 | ||
Yes | 26 | 25 | 2.43 (1.39–4.28) | 0.002 | 2.58 (1.40–4.41) | 0.001 |
Age (in years) | ||||||
< 15 | 12 | 14 | 1 | 1 | ||
15–64 | 283 | 628 | 0.53 (0.24–1.15) | 0.108 | 0.63 (0.28–1.40) | 0.256 |
≥ 65 | 222 | 222 | 0.47 (0.39–1.85) | 0.066 | 0.55 (0.24–1.25) | 0.155 |
Hosmer–Lemeshow goodness of fit test | Prob > chi2 = 0.1889 |