Background
Methods
Study population
Management for cervical polyps during pregnancy
Study procedures
Statistical analysis
Results
Clinical feature | PTB | PTB + Miscarriage | Term delivery |
---|---|---|---|
(N = 15) | (N = 20) | (N = 53) | |
Age | 33.2 ± 5.3 | 32.5 ± 5.2 | 34.3 ± 3.4 |
Nulliparity (%) | 40.0 | 45.0 | 50.9 |
Smoking (%) | 6.6 | 5.0 | 1.8 |
Previous second trimester loss (%) | 26.6 | 35.0** | 13.2 |
History of full-term delivery (%) | 50.0 | 40.0 | 57.1 |
Other maternal diseases (%) | 6.6 | 10.0 | 30.1 |
Uterine anomalies (%) | 6.6 | 15.0 | 0.8 |
Use of vaginal progesterone (%) | 0 | 0 | 0 |
Infertility treatment (%) | 13.3 | 10.0 | 18.8 |
History of PTB (at < 34 weeks) (%) | 40.0 | 33.3 | 13.8 |
Bleeding before polypectomy (%) | 73.3 | 75.0** | 49.0 |
Nugent score (points) | 0 (0–8) | 0 (0–8) | 0 (0–10) |
GA at polypectomy (weeks) | 9 (5–25) | 9 (5–25) | 11 (5–29) |
Polypectomy by twisting (%) | 80.0 | 70.0** | 90.5 |
Polyp width (mm) | 11.1 ± 8.8* | 12.5 ± 8.5** | 6.8 ± 3.9 |
Decidual polyps (%) | 93.3* | 95.0** | 62.2 |
Leukocytes in polyps (/HPF) | 275 ± 128 | 280 ± 147 | 314 ± 201 |
Prelabour rupture of membranes (%) | 26.6 | 25.0 | 11.3 |
h-CAM ≥ stage 2 (%) | 72.7* | 50.0 | 20.0 |
Funisitis (%) | 45.4 | 31.2 | 24.0 |
Offspring GA at birth (weeks) | 29.8 ± 4.8* | 25.8 ± 8.3** | 38.8 ± 1.2 |
Offspring birth weight (g) | 1540 ± 774* | 1365 ± 875** | 3027 ± 392 |
(N = 73) | |||
---|---|---|---|
Clinical feature | Delivery at < 34 weeks or miscarriage > 12 weeks | Delivery at ≥ 34 weeks | p-value |
(N = 16) | (N = 57) | ||
Age | 32.6 ± 4.9 | 34.1 ± 3.7 | 0.283 |
Nulliparity (%) | 50.0 | 49.1 | 0.950 |
Smoking (%) | 6.2 | 1.7 | 0.503 |
Previous second trimester loss (%) | 37.5 | 14.0 | 0.094 |
History of full-term delivery (%) | 33.3 | 56.4 | 0.302 |
Other maternal diseases (%) | 12.5 | 28.0 | 0.201 |
Uterine anomalies (%) | 18.7 | 5.2 | 0.215 |
Use of vaginal progesterone (%) | 0 | 0 | N/A |
Infertility treatment (%) | 6.2 | 17.5 | 0.264 |
History of PTB (at < 34 weeks) (%) | 25.0 | 10.5 | 0.137 |
Bleeding before polypectomy (%) | 87.5* | 47.4 | 0.004 |
Nugent score (points) | 0 (0–8) | 0 (0–5) | 0.640 |
GA at polypectomy (weeks) | 9* (5–13) | 11 (5–29) | < 0.001 |
Polypectomy by twisting (%) | 68.7 | 87.7 | 0.070 |
Polyp Width (mm) | 12.8 ± 7.7* | 7.4 ± 4.4 | 0.012 |
Decidual polyps (%) | 93.7* | 64.9 | 0.024 |
Leukocytes in polyps (/HPF) | 311 ± 147 | 286 ± 198 | 0.683 |
h-CAM ≥ stage 2 (%) | 61.5* | 20.0 | 0.010 |
Funisitis (%) | 38.5 | 24.0 | 0.351 |
Odds ratio | ||
---|---|---|
crude (95% CI) | adjusted (95% CI) | |
(a) Delivery < 34 weeks§of gestation | ||
Polyp width (≥ 12 mm) | 4.0* (1.2–13.1) | 11.8* (2.5–77.5) |
Bleeding before PP | 7.7* (1.6–37.3) | 6.5* (1.2–55.7) |
PP (at ≤10 weeks) | 5.2** (1.3–20.3) | 5.9** (1.2–45.0) |
Decidual polyps | 8.1** (1.00–65.9) | 2.8 (0.37–58.1) |
History of PTB | 2.8 (0.69–11.6) | 0.84 (0.11–5.3) |
(b) Delivery < 37 weeks∮of gestation | ||
Polyp width (≥ 12 mm) | 6.5* (2.0–21.4) | 6.5* (1.6–30.9) |
Bleeding before PP | 3.1** (1.00–9.80) | 1.8 (0.51–7.1) |
PP (at ≤10 weeks) | 3.9** (1.2–12.3) | 4.0** (1.1–17.6) |
Decidual polyps | 11.5* (1.4–92.7) | 1.2 (0.28–5.3) |
History of PTB | 2.6 (0.69–9.78) | 1.4 (0.24–7.2) |
Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | |
---|---|---|---|---|
Polyp width (≥ 12 mm) | 56.2 [50.0] | 86.0 [86.7] | 52.9 [58.8] | 87.5 [82.1] |
Bleeding before polypectomy | 87.5 [75.0] | 52.6 [50.9] | 34.1 [36.5] | 93.7 [84.3] |
Polypectomy at ≤10 weeks | 81.2 [75.0] | 56.1 [56.6] | 34.2 [39.4] | 91.4 [85.7] |
Width & bleeding | 43.7 [35.0] | 93.0 [90.5] | 63.6 [58.3] | 85.5 [78.6] |
Width & polypectomy | 37.5 [35.0] | 94.7 [96.2] | 66.7 [77.7] | 84.4 [79.6] |
Bleeding & polypectomy | 75.0 [60.0] | 75.4 [73.4] | 46.1 [46.1] | 91.5 [82.9] |
Width & bleeding & polypectomy | 31.2 [25.0] | 96.5 [96.2] | 71.4 [71.4] | 83.3 [77.2] |