Background
Methods
Patients
BMD of the femoral neck
Demographic and disease-related data
Statistical analysis
Ethics statement
Consent statement
Results
Comparison of BMD <70 % of YAM and BMD ≥70 % of YAM groups
BMD <70 % of YAM | BMD ≥70 % of YAM | p value | |
---|---|---|---|
Age | 65.0 (58.0–69.0) | 58.0 (53.0–66.0) | 0.0044* |
Proportion female | 93.0 % | 77.9 % | 0.0079* |
Disease duration (year) | 15.0 (8.0–20.0) | 8.0 (4.0–15.0) | 0.0004* |
BMI | 21.4 ± 2.8 | 23.6 ± 3.3 | <0.0001* |
Rate of rheumatoid vasculitis | 1.8 % | 1.6 % | 0.67 |
Proportion taking methylprednisolone | 45.6 % | 40.3 % | 0.52 |
Dose of methylprednisolone (mg) | 2.0 (1.0–3.5) | 3.3 (2.0–6.0) | 0.65 |
CRP (mg/dL) | 0.09 (0.03–0.31) | 0.08 (0.03–0.37) | 0.89 |
DAS28-CRP | 2.63 (1.88–3.38) | 2.50 (1.70–3.30) | 0.49 |
CDAI | 6.70 (2.90–14.90) | 5.80 (2.60–12.95) | 0.54 |
SDAI | 6.95 (3.05–14.10) | 6.30 (2.74–12.94) | 0.58 |
MHAQ score | 9.00 (1.00–14.00) | 4.00 (0.00–8.00) | 0.002* |
History of proximal femoral fracture | 2/57 | 0/129 | 0.087 |
History of thoracic or lumbar vertebral fracture | 17/57 | 9/129 | <0.001* |
Duration of biologics therapy | 4.2 ± 2.6 | 3.6 ± 2.3 | 0.166 |
Association of methylprednisolone therapy on osteoporosis
Association of disease activity on osteoporosis
BMD <70 % of YAM | BMD ≥70 % of YAM | ||
---|---|---|---|
Steinbrocker classification | I | 23 | 69 |
II | 10 | 23 | |
III | 21 | 36 | |
IV | 3 | 1 |
History of vertebral and femoral neck fractures
Association of disease activity on osteoporosis of duration or type of biologics therapy on osteoporosis
BMD <70 % of YAM | BMD ≥70 % of YAM | |
---|---|---|
TNFα inhibitor | 26 | 66 |
Tocilizumab | 6 | 16 |
Abatacept | 3 | 9 |
Switch biologics | 22 | 38 |
Association of disease activity on osteoporosis of duration or type of biologics therapy on osteoporosis of anti-osteoporosis drug therapy on osteoporosis
BMD <70 % of YAM | BMD ≥70 % of YAM | |
---|---|---|
None | 13 | 58 |
Anti-osteoporosis drug use (total) | 44 | 71 |
Multiple logistic regression analysis of factors associated with BMD <70 % of YAM
BMD <70 % of YAM | BMD ≥70 % of YAM | p value | |
---|---|---|---|
Bisphosphonate | 30 | 54 | 0.087 |
PTH | 4 | 1 | 0.008* |
Others | 10 | 16 | 0.351 |
Feature | Odds ratio | 95 % confidence intervals | p value |
---|---|---|---|
Age (per 1 year increase) | 1.065 | 1.015–1.101 | 0.003* |
sex | 5.019 | 1.367–18.43 | 0.015* |
Disease duration (per 1 year increase) | 1.077 | 1.028–1.128 | 0.002* |
History of past vertebral fracture | 7.708 | 2.505–23.72 | <0.001* |
BMI (per 1 point increase) | 0.766 | 0.665–0.883 | <0.001* |
Steinbrocker classification | 2.302 | 1.473–3.597 | <0.001* |