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Cancer Chemotherapy and Pharmacology

Erschienen in:

01.08.2014 | Review Article

Role of pregnane X receptor in chemotherapeutic treatment

verfasst von: Wei Zhuo, Lei Hu, Jinfeng Lv, Hongbing Wang, Honghao Zhou, Lan Fan

Erschienen in: Cancer Chemotherapy and Pharmacology | Ausgabe 2/2014

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Abstract

Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily that differently expresses not only in human normal tissues but also in numerous types of human cancers. PXR can be activated by many endogenous substances and exogenous chemicals, and thus affects chemotherapeutic effects and intervenes drug–drug interactions by regulating its target genes involving drug metabolism and transportation, cell proliferation and apoptosis, and modulating endobiotic homeostasis. Tissue and context-specific regulation of PXR contributes to diverse effects in the treatment for numerous cancers. Genetic variants of PXR lead to intra- and inter-individual differences in the expression and inducibility of PXR, resulting in different responses to chemotherapy in PXR-positive cancers. The purpose of this review is to summarize and discuss the role of PXR in the metabolism and clearance of anticancer drugs. It is also expected that this review will provide insights into PXR-mediated enhancement for chemotherapeutic treatment, prediction of drug–drug interactions and personalized medicine.

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Robbins D, Chen T (2014) Tissue-specific regulation of pregnane X receptor in cancer development and therapy. Cell Biosci 4:17PubMed

Titel: Role of pregnane X receptor in chemotherapeutic treatment
verfasst von: Wei Zhuo
Lei Hu
Jinfeng Lv
Hongbing Wang
Honghao Zhou
Lan Fan
Publikationsdatum: 01.08.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Chemotherapy and Pharmacology / Ausgabe 2/2014
Print ISSN: 0344-5704
Elektronische ISSN: 1432-0843
DOI: https://doi.org/10.1007/s00280-014-2494-9

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Springer Medizin

Role of pregnane X receptor in chemotherapeutic treatment

Abstract

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Springer Medizin

Abstract

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