nach oben

Prevention Science

Erschienen in:

02.02.2019

Role of Social and Sexual Network Factors in PrEP Utilization Among YMSM and Transgender Women in Chicago

verfasst von: Gregory Phillips II, Balint Neray, Michelle Birkett, Dylan Felt, Patrick Janulis, Brian Mustanski

Erschienen in: Prevention Science | Ausgabe 7/2019

Einloggen, um Zugang zu erhalten

Abstract

Despite demonstrated efficacy, uptake of HIV pre-exposure prophylaxis (PrEP) remains low, particularly among high-risk demographics such as transgender women, Black men who have sex with men (BMSM), and young MSM (YMSM). Research thus far has largely focused on individual factors that may impede PrEP uptake in these demographics, leaving social network factors relatively unexplored. The present study used data collected from participants within RADAR, a longitudinal cohort study in Chicago focused on understanding the individual, dyadic, network, social, and biologic factors associated with HIV infection within YMSM. Of the 906 study participants who did not report an HIV diagnosis at baseline, 7.0% reported using PrEP in the prior 6 months. Recent PrEP use was associated with both individual-level (age and gender) and network-level factors (mean relationship strength, sexual network degree, etc.). These findings highlight the need to expand beyond focusing on individual-level drivers of PrEP uptake, as well as changing our understanding of who is most important within a network (centrality vs. strength of weak ties). Future work is needed to determine whether variables associated with PrEP uptake are similarly connected to PrEP adherence.

Amirkhanian, Y. A. (2014). Social networks, sexual networks and HIV risk in men who have sex with men. Current HIV/AIDS Reports, 11, 81–92. https://doi.org/10.1007/s11904-013-0194-4.CrossRefPubMedPubMedCentral

Baeten, J. M., Donnell, D., Ndase, P., Mugo, N. R., Campbell, J. D., Wangisi, J., et al. (2012). Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. The New England Journal of Medicine, 367, 399–410. https://doi.org/10.1056/NEJMoa1108524.CrossRefPubMedPubMedCentral

Baral, S. D., Poteat, T., Stromdahl, S., Wirtz, A. L., Guadamuz, T. E., & Beyrer, C. (2013). Worldwide burden of HIV in transgender women: A systematic review and meta-analysis. The Lancet Infectious Diseases, 13, 214–222. https://doi.org/10.1016/S1473-3099(12)70315-8.CrossRefPubMed

Bauermeister, J. A., Meanley, S., Pingel, E., Soler, J. H., & Harper, G. W. (2013). PrEP awareness and perceived barriers among single young men who have sex with men. Current HIV Research, 11, 520–527.CrossRefPubMedPubMedCentral

Blumenthal, J., & Haubrich, R. H. (2014). Will risk compensation accompany pre-exposure prophylaxis for HIV? Virtual Mentor, 16, 909–915. https://doi.org/10.1001/virtualmentor.2014.16.11.stas1-1411.CrossRefPubMedPubMedCentral

Brennan, J., Kuhns, L. M., Johnson, A. K., Belzer, M., Wilson, E. C., Garofalo, R., & Adolescent Medicine Trials Network for, H. I. V. A. I. (2012). Syndemic theory and HIV-related risk among young transgender women: The role of multiple, co-occurring health problems and social marginalization. American Journal of Public Health, 102, 1751–1757. https://doi.org/10.2105/AJPH.2011.300433.CrossRefPubMedPubMedCentral

Brooks, R. A., Allen, V. C., Jr., Regan, R., Mutchler, M. G., Cervantes-Tadeo, R., & Lee, S. J. (2018). HIV/AIDS conspiracy beliefs and intention to adopt preexposure prophylaxis among black men who have sex with men in Los Angeles. International Journal of STD & AIDS, 29, 375–381. https://doi.org/10.1177/0956462417727691.CrossRef

Centers for Disease Control and Prevention. (2017a). CDC fact sheet: HIV among gay and bisexual men. Atlanta, Georgia: Division of HIV/AIDS prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services.

Centers for Disease Control and Prevention. (2017b). Diagnoses of HIV infection in the United States and dependent areas, 2016. Atlanta, Georgia: Division of HIV/AIDS prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services Retrieved from https://www.cdc.gov/hiv/library/reports/hiv-surveillance.html.

Centers for Disease Control and Prevention. (2018). HIV Among Transgender People. Atlanta, Georgia: Division of HIV/AIDS prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services. Retrieved from https://www.cdc.gov/hiv/pdf/group/gender/transgender/cdc-hiv-transgender-factsheet.pdf.

Clark, H., Babu, A. S., Wiewel, E. W., Opoku, J., & Crepaz, N. (2017). Diagnosed HIV infection in transgender adults and adolescents: Results from the national HIV surveillance system, 2009-2014. AIDS and Behavior, 21, 2774–2783. https://doi.org/10.1007/s10461-016-1656-7.CrossRefPubMedPubMedCentral

Csardi, G., Nepusz, T. (2006). The igraph software package for complex network research. Interjournal, Complex Systems 1695.

Deutsch, M. B., Glidden, D. V., Sevelius, J., Keatley, J., McMahan, V., Guanira, J., et al. (2015). HIV pre-exposure prophylaxis in transgender women: A subgroup analysis of the iPrEx trial. Lancet HIV, 2, e512–e519. https://doi.org/10.1016/S2352-3018(15)00206-4.CrossRefPubMedPubMedCentral

Feinstein, B. A., McConnell, E., Dyar, C., Mustanski, B., & Newcomb, M. E. (2018). Minority stress and relationship functioning among young male same-sex couples: An examination of actor-partner interdependence models. Journal of Consulting and Clinical Psychology, 86, 416–426. https://doi.org/10.1037/ccp0000296.CrossRefPubMedPubMedCentral

Final Guidance on Maintaining, Collecting, and Reporting Racial and Ethnic Data to the U.S. Department of Education, 71 FR 44866 c.F.R. (2007).

Fisher, C. B., Fried, A. L., Desmond, M., Macapagal, K., & Mustanski, B. (2017). Facilitators and barriers to participation in PrEP HIV prevention trials involving transgender male and female adolescents and emerging adults. AIDS Education and Prevention, 29, 205–217. https://doi.org/10.1521/aeap.2017.29.3.205.CrossRefPubMedPubMedCentral

Freeborn, K., & Portillo, C. J. (2018). Does pre-exposure prophylaxis for HIV prevention in men who have sex with men change risk behaviour? A systematic review. Journal of Clinical Nursing, 27, 3254–3265. https://doi.org/10.1111/jocn.13990.CrossRefPubMedPubMedCentral

Garcia, M., & Harris, A. L. (2017). PrEP awareness and decision-making for Latino MSM in San Antonio, Texas. PLoS One, 12, e0184014. https://doi.org/10.1371/journal.pone.0184014.CrossRefPubMedPubMedCentral

Granovetter, M. S. (1973). The strength of weak ties. American Journal of Sociology, 78, 1360–1380. https://doi.org/10.1086/225469.CrossRef

Grant, R. M., Lama, J. R., Anderson, P. L., McMahan, V., Liu, A. Y., Vargas, L., & iPrEx Study, T. (2010). Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. The New England Journal of Medicine, 363, 2587–2599. https://doi.org/10.1056/NEJMoa1011205.CrossRefPubMedPubMedCentral

Haberer, J. E., Sabin, L., Amico, K. R., Orrell, C., Galarraga, O., Tsai, A. C., et al. (2017). Improving antiretroviral therapy adherence in resource-limited settings at scale: A discussion of interventions and recommendations. Journal of the International AIDS Society, 20, 21371. https://doi.org/10.7448/IAS.20.1.21371.CrossRefPubMedPubMedCentral

Harawa, N. T., Holloway, I. W., Leibowitz, A., Weiss, R., Gildner, J., Landovitz, R. J., et al. (2017). Serious concerns regarding a meta-analysis of preexposure prophylaxis use and STI acquisition. AIDS, 31, 739–740. https://doi.org/10.1097/QAD.0000000000001386.CrossRefPubMed

Hogan, B., Melville, J. R., Philips, G. L., 2nd, Janulis, P., Contractor, N., Mustanski, B. S., & Birkett, M. (2016). Evaluating the paper-to-screen translation of participant-aided sociograms with high-risk participants. Proceedings of the 2016 CHI Conference on Human Factors in Computing Systems, 2016, 5360–5371. https://doi.org/10.1145/2858036.2858368.CrossRef

Holloway, I. W., Tan, D., Gildner, J. L., Beougher, S. C., Pulsipher, C., Montoya, J. A., et al. (2017). Facilitators and barriers to pre-exposure prophylaxis willingness among young men who have sex with men who use geosocial networking applications in California. AIDS Patient Care and STDs, 31, 517–527. https://doi.org/10.1089/apc.2017.0082.CrossRefPubMedPubMedCentral

Jeffries, W. L., Garrett, S., Phields, M., Olubajo, B., Lemon, E., Valdes-Salgado, R., & Collins, C. B. (2017). Implementation of evidence-based HIV interventions for gay, bisexual, and other men who have sex with men. AIDS and Behavior, 21, 3000–3012. https://doi.org/10.1007/s10461-017-1813-7.CrossRefPubMed

Khanna, A. S., Michaels, S., Skaathun, B., Morgan, E., Green, K., Young, L., et al. (2016). Preexposure prophylaxis awareness and use in a population-based sample of young Black men who have sex with men. JAMA Internal Medicine, 176, 136–138. https://doi.org/10.1001/jamainternmed.2015.6536.CrossRefPubMedPubMedCentral

Khanna, A. S., Schumm, P., & Schneider, J. A. (2017). Facebook network structure and awareness of preexposure prophylaxis among young men who have sex with men. Annals of Epidemiology, 27, 176–180. https://doi.org/10.1016/j.annepidem.2016.11.006.CrossRefPubMed

Kuhns, L. M., Hotton, A. L., Schneider, J., Garofalo, R., & Fujimoto, K. (2017). Use of pre-exposure prophylaxis (PrEP) in young men who have sex with men is associated with race, sexual risk behavior and peer network size. AIDS and Behavior, 21, 1376–1382. https://doi.org/10.1007/s10461-017-1739-0.CrossRefPubMedPubMedCentral

Latkin, C., Yang, C., Tobin, K., Roebuck, G., Spikes, P., & Patterson, J. (2012). Social network predictors of disclosure of MSM behavior and HIV-positive serostatus among African American MSM in Baltimore, Maryland. AIDS and Behavior, 16, 535–542. https://doi.org/10.1007/s10461-011-0014-z.CrossRefPubMedPubMedCentral

Latkin, C., Davey-Rothwell, M. A., Knowlton, A. R., Alexander, K. A., Williams, C. T., & Boodram, B. (2013). Social network approaches to recruitment, HIV prevention, medical care, and medication adherence. Journal of Acquired Immune Deficiency Syndromes, 63, S54–S58. https://doi.org/10.1097/QAI.0b013e3182928e2a.CrossRefPubMed

Levy, M. E., Wilton, L., Phillips, G., 2nd, Glick, S. N., Kuo, I., Brewer, R. A., et al. (2014). Understanding structural barriers to accessing HIV testing and prevention services among black men who have sex with men (BMSM) in the United States. AIDS and Behavior, 18, 972–996. https://doi.org/10.1007/s10461-014-0719-x.CrossRefPubMedPubMedCentral

Maksut, J. L., Eaton, L. A., Siembida, E. J., Driffin, D. D., & Baldwin, R. (2016). An evaluation of factors associated with sexual risk taking among Black men who have sex with men: A comparison of younger and older populations. Journal of Behavioral Medicine, 39, 665–674. https://doi.org/10.1007/s10865-016-9734-x.CrossRefPubMedPubMedCentral

Marshall, B. D., & Mimiaga, M. J. (2015). Uptake and effectiveness of PrEP for transgender women. Lancet HIV, 2, e502–e503. https://doi.org/10.1016/S2352-3018(15)00224-6.CrossRefPubMedPubMedCentral

McCormack, S., Dunn, D. T., Desai, M., Dolling, D. I., Gafos, M., Gilson, R., et al. (2016). Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): Effectiveness results from the pilot phase of a pragmatic open-label randomised trial. Lancet, 387, 53–60. https://doi.org/10.1016/S0140-6736(15)00056-2.CrossRefPubMedPubMedCentral

Miyazaki, Y., & Raudenbush, S. W. (2000). Tests for linkage of multiple cohorts in an accelerated longitudinal design. Psychological Methods, 5, 44–63.CrossRefPubMed

Moore, K., Dell, S., Oliva, M., Morgan, A., Rothman, R., Hsieh, Y. H., & Arrington-Sanders, R. (2018). Does parental insurance impact willingness to take prep in adolescents & young adults? Journal of Adolescent Health, 62, S23–S24.CrossRef

Morgan, E., Moran, K., Ryan, D. T., Mustanski, B., & Newcomb, M. E. (2018). Threefold increase in PrEP uptake over time with high adherence among young men who have sex with men in Chicago. AIDS and Behavior, In Press. doi:https://doi.org/10.1007/s10461-018-2122-5.

Mustanski, B., Garofalo, R., & Emerson, E. M. (2010). Mental health disorders, psychological distress, and suicidality in a diverse sample of lesbian, gay, bisexual, and transgender youths. American Journal of Public Health, 100, 2426–2432. https://doi.org/10.2105/AJPH.2009.178319.CrossRefPubMedPubMedCentral

Mustanski, B., Johnson, A. K., Garofalo, R., Ryan, D., & Birkett, M. (2013). Perceived likelihood of using HIV pre-exposure prophylaxis medications among young men who have sex with men. AIDS and Behavior, 17, 2173–2179. https://doi.org/10.1007/s10461-012-0359-y.CrossRefPubMedPubMedCentral

Mustanski, B., Ryan, D. T., Hayford, C., Phillips 2nd, G., Newcomb, M. E., & Smith, J. D. (2018). Geographic and individual associations with PrEP stigma: Results from the RADAR cohort of diverse young men who have sex with men and transgender women. AIDS and Behavior, In Press. doi:https://doi.org/10.1007/s10461-018-2159-5.

Nguyen, V. K., Greenwald, Z. R., Trottier, H., Cadieux, M., Goyette, A., Beauchemin, M., et al. (2018). Incidence of sexually transmitted infections before and after preexposure prophylaxis for HIV. AIDS, 32, 523–530. https://doi.org/10.1097/QAD.0000000000001718.CrossRefPubMed

Ojikutu, B. O., Bogart, L. M., Higgins-Biddle, M., Dale, S. K., Allen, W., Dominique, T., & Mayer, K. H. (2018). Facilitators and barriers to pre-exposure prophylaxis (PrEP) use among Black individuals in the United States: Results from the National Survey on HIV in the Black community (NSHBC). AIDS and Behavior, 22, 3576–3587. https://doi.org/10.1007/s10461-018-2067-8.CrossRefPubMedPubMedCentral

Perez-Figueroa, R. E., Kapadia, F., Barton, S. C., Eddy, J. A., & Halkitis, P. N. (2015). Acceptability of PrEP uptake among racially/ethnically diverse young men who have sex with men: The P18 Study. AIDS Education and Prevention, 27, 112–125. https://doi.org/10.1521/aeap.2015.27.2.112.CrossRefPubMedPubMedCentral

Philbin, M. M., Parker, C. M., Parker, R. G., Wilson, P. A., Garcia, J., & Hirsch, J. S. (2016). The promise of pre-exposure prophylaxis for Black men who have sex with men: An ecological approach to attitudes, beliefs, and barriers. AIDS Patient Care and STDs, 30, 282–290. https://doi.org/10.1089/apc.2016.0037.CrossRefPubMedPubMedCentral

Pinto, R. M., Berringer, K. R., Melendez, R., & Mmeje, O. (2018). Improving PrEP implementation through multilevel interventions: A synthesis of the literature. AIDS and Behavior. https://doi.org/10.1007/s10461-018-2184-4.

Poteat, T., German, D., & Flynn, C. (2016). The conflation of gender and sex: Gaps and opportunities in HIV data among transgender women and MSM. Global Public Health, 11, 835–848. https://doi.org/10.1080/17441692.2015.1134615.CrossRefPubMedPubMedCentral

R Core Team. (2017). R: A language and environment for statistical computing. In. Vienna, Austria: R Foundation for Statistical Computing.

Sevelius, J. M., Keatley, J., Calma, N., & Arnold, E. (2016). 'I am not a man': Trans-specific barriers and facilitators to PrEP acceptability among transgender women. Global Public Health, 11, 1060–1075. https://doi.org/10.1080/17441692.2016.1154085.CrossRefPubMed

Strauss, B. B., Greene, G. J., Phillips, G., 2nd, Bhatia, R., Madkins, K., Parsons, J. T., & Mustanski, B. (2017). Exploring patterns of awareness and use of HIV pre-exposure prophylaxis among young men who have sex with men. AIDS and Behavior, 21, 1288–1298. https://doi.org/10.1007/s10461-016-1480-0.CrossRefPubMedPubMedCentral

Syed, S. T., Gerber, B. S., & Sharp, L. K. (2013). Traveling towards disease: Transportation barriers to health care access. Journal of Community Health, 38, 976–993. https://doi.org/10.1007/s10900-013-9681-1.CrossRefPubMedPubMedCentral

Theall, K. P., Fleckman, J., & Jacobs, M. (2015). Impact of a community popular opinion leader intervention among African American adults in a southeastern United States community. AIDS Education and Prevention, 27, 275–287. https://doi.org/10.1521/aeap.2015.27.3.275.CrossRefPubMedPubMedCentral

Thigpen, M. C., Kebaabetswe, P. M., Paxton, L. A., Smith, D. K., Rose, C. E., Segolodi, T. M., et al. (2012). Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. The New England Journal of Medicine, 367, 423–434. https://doi.org/10.1056/NEJMoa1110711.CrossRefPubMed

Volk, J. E., Marcus, J. L., Phengrasamy, T., Blechinger, D., Nguyen, D. P., Follansbee, S., & Hare, C. B. (2015). No new HIV infections with increasing use of HIV preexposure prophylaxis in a clinical practice setting. Clinical Infectious Diseases, 61, 1601–1603. https://doi.org/10.1093/cid/civ778.CrossRefPubMedPubMedCentral

Wasserman, S., & Faust, K. (1994). Social network analysis : methods and applications. Cambridge: Cambridge University Press.CrossRef

Wilson, E., Jin, H., Liu, A., & Raymond, H. F. (2015). Knowledge, indications and willingness to take pre-exposure prophylaxis among transwomen in San Francisco, 2013. PLoS One, 10, e0128971. https://doi.org/10.1371/journal.pone.0128971.CrossRefPubMedPubMedCentral

Wilson, E., Chen, Y. H., Pomart, W. A., & Arayasirikul, S. (2016). Awareness, interest, and HIV pre-exposure prophylaxis candidacy among young transwomen. AIDS Patient Care and STDs, 30, 147–150. https://doi.org/10.1089/apc.2015.0266.CrossRefPubMedPubMedCentral

Young, L. E., Schumm, P., Alon, L., Bouris, A., Ferreira, M., Hill, B., et al. (2018). PrEP Chicago: A randomized controlled peer change agent intervention to promote the adoption of pre-exposure prophylaxis for HIV prevention among young Black men who have sex with men. Clinical Trials, 15, 44–52. https://doi.org/10.1177/1740774517730012.CrossRefPubMed

Titel: Role of Social and Sexual Network Factors in PrEP Utilization Among YMSM and Transgender Women in Chicago
verfasst von: Gregory Phillips II
Balint Neray
Michelle Birkett
Dylan Felt
Patrick Janulis
Brian Mustanski
Publikationsdatum: 02.02.2019
Verlag: Springer US
Erschienen in: Prevention Science / Ausgabe 7/2019
Print ISSN: 1389-4986
Elektronische ISSN: 1573-6695
DOI: https://doi.org/10.1007/s11121-019-00995-6

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 7/2019

Effects of Social Development Intervention in Childhood on Adult Life at Ages 30 to 39

Mind the Gap: Bridging the Divide Between Current Binge Drinking Prevention and the Needs of Hispanic Underage Emerging Adults

Patterns of Family, School, and Community Promotive Factors and Health Disparities Among Youth: Implications for Prevention Science

Addressing the Adherence-Adaptation Debate: Lessons from the Replication of an Evidence-Based Sexual Health Program in School Settings

Differential Consequences: Racial/Ethnic and Gender Differences in the Enduring Impact of Early Disadvantage on Heavy Drinking in Midlife

Predictive Association of Smoking with Depressive Symptoms: a Longitudinal Study of Adolescent Twins