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01.07.2013 | Original Article

Roles of alcohol drinking pattern in fatty liver in Japanese women

verfasst von: Akio Moriya, Yoshiaki Iwasaki, Souhei Ohguchi, Eizo Kayashima, Tadahiko Mitsumune, Fusao Ikeda, Masaharu Ando, Kazuhide Yamamoto

Erschienen in: Hepatology International | Ausgabe 3/2013

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Abstract

Purpose

Several studies have reported an inverse association between moderate alcohol consumption and prevalence of fatty liver (FL) in men. We aimed to clarify this association in women.

Methods

We collected health checkup data from 4,921 Japanese women without concurrent liver disease (mean age 46.4 years) and performed a cross-sectional study to evaluate the influence of alcohol drinking patterns (frequency and amount) on the prevalence of FL as assessed by ultrasonography.

Results

Alcohol consumption was reported in 30.8 % of participants, and FL was observed in 13.8 % (15.5 % nondrinkers, 10.1 % drinkers). Alcohol consumption was inversely associated with FL prevalence [adjusted odds ratio (AOR) 0.79, 95 % confidence interval (CI) 0.63–0.98]. In analyses stratified by drinking frequency and/or amount of alcohol consumed, the risk of FL decreased for the following categories: 0.1–19.9 g/drinking day (AOR 0.61, 95 % CI 0.44–0.83) and 0.1–69.9 g/week (AOR 0.74, 95 % CI 0.55–0.98). The amount of alcohol consumed directly correlated with the prevalence of FL in daily drinkers (p < 0.05), whereas there was no correlation between the frequency of alcohol consumption and FL prevalence. Alanine aminotransferase levels were significantly lower for the following categories: 0.1–19.9 g/drinking day for 1–3 days a week (p = 0.016) and 0.1–69.9 g within 1–3 drinking days a week (p = 0.004).

Conclusions

Minimal alcohol consumption appears to have protective effects against nonalcoholic FL disease in women, although an increase in the amount of alcohol consumed appears to nullify the protective effect.

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Titel: Roles of alcohol drinking pattern in fatty liver in Japanese women
verfasst von: Akio Moriya
Yoshiaki Iwasaki
Souhei Ohguchi
Eizo Kayashima
Tadahiko Mitsumune
Fusao Ikeda
Masaharu Ando
Kazuhide Yamamoto
Publikationsdatum: 01.07.2013
Verlag: Springer India
Erschienen in: Hepatology International / Ausgabe 3/2013
Print ISSN: 1936-0533
Elektronische ISSN: 1936-0541
DOI: https://doi.org/10.1007/s12072-013-9449-9

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Roles of alcohol drinking pattern in fatty liver in Japanese women