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European Journal of Applied Physiology
Erschienen in:

22.10.2016 | Original Article

Salbutamol effects on systemic potassium dynamics during and following intense continuous and intermittent exercise

verfasst von: Muath M. Altarawneh, Aaron Petersen, Robert Smith, David M. Rouffet, Francois Billaut, Ben D. Perry, Victoria L. Wyckelsma, Antony Tobin, Michael J. McKenna

Erschienen in: European Journal of Applied Physiology | Ausgabe 11-12/2016

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Abstract

Purpose

Salbutamol inhalation is permissible by WADA in athletic competition for asthma management and affects potassium regulation, which is vital for muscle function. Salbutamol effects on arterial potassium concentration ([K+]a) during and after high-intensity continuous exercise (HIcont) and intermittent exercise comprising repeated, brief sprints (HIint), and on performance during HIint are unknown and were investigated.

Methods

Seven recreationally active men participated in a double-blind, randomised, cross-over design, inhaling 1000 µg salbutamol or placebo. Participants cycled continuously for 5 min at 40 % \( {\dot{\text{V}}} \)O2peak and 60 % \( {\dot{\text{V}}} \)O2peak, then HIcont (90 s at 130 % \( {\dot{\text{V}}} \)O2peak), 20 min recovery, and then HIint (3 sets, 5 × 4 s sprints), with 30 min recovery.

Results

Plasma [K+]a increased throughout exercise and subsequently declined below baseline (P < 0.001). Plasma [K+]a was greater during HIcont than HIint (P < 0.001, HIcont 5.94 ± 0.65 vs HIint set 1, 4.71 ± 0.40 mM); the change in [K+]a from baseline (Δ[K+]a) was 2.6-fold greater during HIcont than HIint (P < 0.001). The Δ[K+] throughout the trial was less with salbutamol than placebo (P < 0.001, treatment main effect, 0.03 ± 0.67 vs 0.22 ± 0.69 mM, respectively); and remained less after correction for fluid shifts (P < 0.001). The Δ[K+] during HIcont was less after salbutamol (P < 0.05), but not during HIint. Blood lactate, plasma pH, and the work output during HIint did not differ between trials.

Conclusions

Inhaled salbutamol modulated the [K+]a rise across the trial, comprising intense continuous and intermittent exercise and recovery, lowering Δ[K+] during HIcont. The limited [K+]a changes during HIint suggest that salbutamol is unlikely to influence systemic [K+] during periods of intense effort in intermittent sports.
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Metadaten
Titel
Salbutamol effects on systemic potassium dynamics during and following intense continuous and intermittent exercise
verfasst von
Muath M. Altarawneh
Aaron Petersen
Robert Smith
David M. Rouffet
Francois Billaut
Ben D. Perry
Victoria L. Wyckelsma
Antony Tobin
Michael J. McKenna
Publikationsdatum
22.10.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Applied Physiology / Ausgabe 11-12/2016
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-016-3481-0

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