Introduction
Materials and methods
Study population
Cardiovascular magnetic resonance acquisition and data preparation
KE analysis over LV diastole
Viscous EL analysis over LV diastole
Integral vorticity magnitude over LV diastole (vorticity_LV)
Scan–rescan analysis
Statistical analysis
Results
Scan-independent characteristics | |||
---|---|---|---|
N | 12 | ||
Male (%) | 6/12 (50%) | ||
Age (years) | 27 ± 3 | ||
Height (cm) | 175 ± 7 | ||
Weight (kg) | 69 ± 12 | ||
BSA (m2) | 1.8 ± 0.2 | ||
BMI (kg/m2) | 22 ± 3 |
Characteristics per scan | Scan 1 | Scan 2 | P value |
---|---|---|---|
HR (bpm) | 60.8 ± 7.8 | 59.9 ± 6.9 | 0.52 |
End-diastolic volume (mL) | 143.8 (132.4–183.8) | 158.6 ± 30.3 | 0.64 |
End-systolic volume (mL) | 59.0 ± 12.8 | 56.2 ± 12.9 | 0.27 |
Stroke volume (mL) | 100.8 ± 21.8 | 102.4 ± 21.0 | 0.44 |
Ejection fraction (%) | 62.8 ± 3.6 | 63.1 (61.6–65.4) | 0.21 |
CO (L/min) | 5.5 ± 0.9 | 5.6 ± 1.3 | 0.75 |
\({\text{Intra-scan comparison of energetics (KE vs.}}\,\mathop {{\text{EL}}}\limits^. )\)
Scan–rescan analysis of kinetic energy and viscous energy loss rate over early diastolic filling
Scan 1 | Scan 2 | Difference (scan 2–scan 1) | Pearson correlation coefficient | Intraclass correlation coefficient | Coefficient of variation (%) | |
---|---|---|---|---|---|---|
Mean ± SD (min–max) or median [IQR] (min–max) | Mean ± SD (min–max) or median [IQR] (min–max) | Mean ± SD or (min–max) median [IQR] (min–max) | ICC (95% CI) | |||
Early filling | ||||||
KEE-peak (mJ) | 4.9 ± 1.9 (2.6–9.6) | 4.8 ± 1.4 (2.0–7.6) | 0.1 ± 2.3 (− 4.8 to 5.0) | 0.06 | 0.12 (− 2.78 to 0.76) | 28 |
KEE-avg (mJ) | 1.9 ± 0.7 (0.8–3.5) | 1.9 [1.3–2.3] (1.1–4.0)c | − 0.01 [− 0.1 to 0.3] (− 2.2 to 2.1)c | 0.52 | 0.31 (− 1.85 to 0.81) | 26 |
\(\mathop {{\text{EL}}}\limits^{\bullet}\)E-peak (mW) | 1.5 ± 0.4 (0.8–2.1) | 1.5 ± 0.6 (0.7–2.9) | 0.04 ± 0.7 (− 1.4 to 1.7) | 0.02 | 0.04 (− 3.25 to 0.74) | 31 |
norm_\(\mathop {{\text{EL}}}\limits^{\bullet}\)E-peak (W/m3) | 15.2 ± 5.1 (9.4–24.9) | 14.9 ± 5.1 (6.0–21.8) | − 0.2 ± 6.2 (− 12.6 to 12.3) | 0.27 | 0.45 (− 1.17 to 0.85) | 30 |
\(\mathop {{\text{EL}}}\limits^{\bullet}\)E-avg (mW) | 0.7 ± 0.2 (0.3–1.1) | 0.7 ± 0.3 (0.4–1.4) | − 0.01 [− 0.1 to 0.3] (− 0.7 to 0.8)c | 0.11 | 0.21 (− 2.36 to 0.78) | 28 |
norm_\(\mathop {{\text{EL}}}\limits^{\bullet}\)E-avg (W/m3) | 7.0 ± 2.3 (4.2–11.4) | 6.6 ± 2.1 (3.2–10.4) | − 0.4 ± 2.8 (− 6.4 to 5.8) | 0.20 | 0.35 (− 1.55 to 0.82) | 28 |
Late filling | ||||||
KEA−peak (mJ) | 0.9 [0.7–2.0] (0.7–2.5)c | 1.0 [0.9–1.6] (0.6–2.6)c | 0.1 [− 0.2 to 0.3] (− 1.2 to 0.5)c | 0.62b | 0.87 (0.55–0.96)b | 23 |
KEA−avg (mJ) | 0.6 [0.5–1.2] (0.4–1.4)c | 0.8 ± 0.4 (0.4–1.6) | − 0.03 ± 0.3 (− 0.7 to 0.4) | 0.68b | 0.84 (0.42–0.95)b | 23 |
\(\mathop {{\text{EL}}}\limits^{\bullet}\)A−peak (mW) | 0.5 ± 0.3 (0.3–1.1) | 0.5 ± 0.2 (0.3–1.0) | − 0.007 ± 0.2 (–0.5 to 0.3) | 0.67b | 0.81 (0.33–0.95)b | 24 |
norm_\(\mathop {{\text{EL}}}\limits^{\bullet}\)A−peak (W/m3) | 5.3 ± 1.8 (2.5–8.3) | 5.1 ± 1.5 (3.3–7.9) | − 0.2 ± 1.7 (− 3.2 to 2.2) | 0.50 | 0.68 (− 0.19 to 0.91)b | 22 |
\(\mathop {{\text{EL}}}\limits^{\bullet}\)A−avg (mW) | 0.3 [0.2–0.6] (0.2–0.7)c | 0.4 ± 0.2 (0.2–0.8) | − 0.02 ± 0.1 (− 0.4 to 0.2) | 0.50 | 0.80 (0.29–0.94)b | 23 |
norm_\(\mathop {{\text{EL}}}\limits^{\bullet}\)A−avg (W/m3) | 3.7 ± 1.3 (2.1–6.6) | 3.4 ± 1.1 (2.2–5.2) | − 0.3 ± 1.1 (− 2.8 to 1.5) | 0.58b | 0.73 (0.07–0.92)b | 21 |
Total diastole | ||||||
ELtotal diastole (mJ) | 0.5 ± 0.2 (0.3–1.0) | 0.5 [0.4–0.6] (0.3–1.3)c | − 0.006 [− 0.07 to 0.06] (− 0.4 to 0.7)c | 0.81b | 0.58 (− 0.60 to 0.88) | 22 |
norm_ELtotal diastole (J/m3) | 5.3 ± 1.5 (3.4–8.1) | 4.8 [4.2–5.3] (3.1–9.8)c | − 0.1 ± 2.2 (− 3.9 to 5.3) | 0.30 | 0.17 (− 2.52 to 0.77) | 23 |
ELindex | 0.3 ± 0.07 (0.2–0.4) | 0.3 ± 0.06 (0.2–0.4) | − 0.001 ± 0.03 (− 0.04 to 0.06) | 0.89a | 0.94 (0.80–0.98)a | 9 |
Scan 1 | Scan 2 | Difference (scan 2–scan 1) | Pearson correlation coefficient | Intraclass correlation coefficient | Coefficient of variation (%) | |
---|---|---|---|---|---|---|
Mean ± SD (min–max) or median [IQR] (min–max) | Mean ± SD (min–max) or median [IQR] (min–max) | Mean ± SD or (min–max) median [IQR] (min–max) | ICC (95% CI) | |||
Early filling | ||||||
KEE-peak (mJ) | 5.0 [4.0–5.3] (2.0–5.4)c | 4.6 ± 1.1 (2.6–6.4) | 0.1 ± 0.9 (− 0.9 to 2.0) | 0.62 | 0.82 (0.27–0.96)b | 15 |
KEE-avg (mJ) | 1.7 ± 0.5 (0.8–2.3) | 1.8 ± 0.5 (1.1–2.4) | 0.05 ± 0.2 (− 0.2 to 0.5) | 0.91a | 0.95 (0.82–0.99)a | 10 |
\(\mathop {{\text{EL}}}\limits^{\bullet}\)E-peak (mW) | 1.5 ± 0.4 (0.8–2.1) | 1.5 ± 0.4 (0.7–2.2) | 0.01 ± 0.4 (− 0.5 to 0.9) | 0.58 | 0.76 (− 0.07 to 0.94)b | 17 |
norm_\(\mathop {{\text{EL}}}\limits^{\bullet}\)E-peak (W/m3) | 15.4 ± 5.2 (9.6–24.9) | 15.2 ± 4.2 (8.9–21.8) | − 0.3 ± 3.5 (− 4.7 to 6.9) | 0.75b | 0.86 (0.40–0.97)b | 16 |
\(\mathop {{\text{EL}}}\limits^{\bullet}\)E-avg (mW) | 0.7 ± 0.2 (0.3–0.9) | 0.6 ± 0.2 (0.4–0.9) | − 0.02 ± 0.1 (− 0.2 to 0.2) | 0.83b | 0.91 (0.64–0.98)b | 11 |
norm_\(\mathop {{\text{EL}}}\limits^{\bullet}\)E-avg (W/m3) | 7.0 ± 2.3 (4.2–11.4) | 6.6 ± 1.6 (4.2–9.0) | − 0.4 ± 1.2 (− 2.4 to 1.6) | 0.87b | 0.90 (0.60–0.97)b | 12 |
Late filling | ||||||
KEA−peak (mJ) | 0.9 [0.7–1.7] (0.7–2.5)c | 1.2 ± 0.5 (0.6–2.4) | 0.2 [− 0.1 to 0.3] (− 1.2 to 0.5)c | 0.59 | 0.83 (0.25–0.96)b | 23 |
KEA−avg(mJ) | 0.5 [0.5–1.2] (0.4–1.4)c | 0.7 ± 0.3 (0.4–1.3) | − 0.02 ± 0.3 (− 0.7 to 0.4) | 0.65b | 0.77 (0.02–0.94)b | 23 |
\(\mathop {{\text{EL}}}\limits^{\bullet}\)A−peak (mW) | 0.4 [0.3–0.7] (0.3–1.1)c | 0.5 ± 0.2 (0.3–0.9) | − 0.03 ± 0.2 (− 0.5 to 0.3) | 0.50 | 0.79 (0.11–0.95)b | 25 |
norm_\(\mathop {{\text{EL}}}\limits^{\bullet}\)A−peak (W/m3) | 5.3 ± 2.0 (2.5–8.3) | 5.0 ± 1.3 (3.3–7.0) | − 0.3 ± 1.7 (− 3.2 to 2.2) | 0.49 | 0.64 (− 0.56 to 0.91) | 24 |
\(\mathop {{\text{EL}}}\limits^{\bullet}\)A−avg (mW) | 0.3 [0.2–0.6] (0.2–0.8)c | 0.3 ± 0.1 (0.2–0.6) | − 0.03 ± 0.1 (− 0.4 to 0.2) | 0.42 | 0.75 (− 0.05 to 0.94)b | 24 |
norm_\(\mathop {{\text{EL}}}\limits^{\bullet}\)A−avg (W/m3) | 3.6 ± 1.4 (2.1–6.6) | 3.4 ± 1.0 (2.3–5.2) | − 0.3 ± 1.2 (− 2.8 to 1.5) | 0.57 | 0.70 (− 0.21 to 0.93)b | 22 |
Total diastole | ||||||
ELtotal diastole (mJ) | 0.5 ± 0.2 (0.3–1.0) | 0.5 ± 0.1 (0.3–0.7) | − 0.01 [− 0.05 to 0.03] (− 0.3 to 0.08)c | 0.88b | 0.91 (0.64–0.98)b | 11 |
norm_ELtotal diastole (J/m3) | 5.1 ± 1.3 (3.4–7.0) | 4.8 ± 0.9 (3.1–6.4) | − 0.3 ± 0.9 (− 2.0 to 1.2) | 0.73b | 0.81 (0.27–0.95)b | 12 |
ELindex | 0.3 ± 0.06 (0.2–0.4) | 0.3 ± 0.07 (0.2–0.4) | − 0.01 ± 0.03 (− 0.04 to 0.06) | 0.89a | 0.95 (0.79–0.99)a | 8 |
Scan–rescan analysis of kinetic energy and viscous energy loss rate over late diastolic filling
Scan–rescan analysis of kinetic energy and viscous energy loss over total diastole
Scan–rescan analysis of volumetric vorticity_LV over early diastolic filling
Scan 1 | Scan 2 | Difference (scan 2–scan 1) | Pearson correlation coefficient | Intraclass correlation coefficient | Coefficient of variation (%) | |
---|---|---|---|---|---|---|
Mean ± SD (min–max) or median [IQR] (min–max) | Mean ± SD (min–max) or median [IQR] (min–max) | Mean ± SD (min–max) or median [IQR] (min–max) | ICC (95% CI) | |||
Early filling | ||||||
Vorticity_LVE-peak (mL/s) | 4671 ± 992 (2950–6370) | 4551 ± 1043 (2930–6200) | − 120 ± 1075 (− 239 to 1710) | 0.44 | 0.63 (− 0.37 to 0.90) | 15 |
Vorticity_LVE-avg (mL/s) | 2862 ± 636 (1720–3840) | 2788 ± 671 (1810–3930) | − 74 ± 608 (− 1510 to 1060) | 0.57 | 0.74 (0.06–0.93)b | 13 |
Late filling | ||||||
Vorticity_LVA−peak (mL/s) | 2715 [2502–4142] (2176–5463)c | 3193 ± 945 (2174–4914) | − 10 ± 547 (− 1270 to 840) | 0.75b | 0.92 (0.73–0.98)a | 11 |
Vorticity_LVA−avg (mL/s) | 2660 ± 842 (1740–4180) | 2599 ± 766 (1730–4050) | − 61 ± 484 (− 1270 to 740) | 0.82b | 0.91 (0.68–0.97)a | 11 |
Scan 1 | Scan 2 | Difference (scan 2–scan 1) | Pearson correlation coefficient | Intraclass correlation coefficient | Coefficient of variation (%) | |
---|---|---|---|---|---|---|
Mean ± SD (min–max) or median [IQR] (min–max) | Mean ± SD (min–max) or median [IQR] (min–max) | Mean ± SD (min–max) or median [IQR] (min–max) | ICC (95% CI) | |||
Early filling | ||||||
Vorticity_LVE-peak (mL/s) | 4546 ± 1008 (2950–6370) | 4520 ± 1004 (2930–6200) | − 27 ± 796 (− 940 to 1710) | 0.69b | 0.83 (0.27–0.96)b | 11 |
Vorticity_LVE-avg (mL/s) | 2764 ± 614 (1720–3560) | 2720 ± 613 (1810–3610) | − 44 ± 277 (− 380 to 480) | 0.90a | 0.95 (0.80–0.99)a | 7 |
Late filling | ||||||
Vorticity_LVA−peak (mL/s) | 2563 [2468–3628] (2176–5463)c | 3012 ± 852 (2174–4586) | − 69 ± 575 (− 1270 to 840) | 0.64b | 0.91 (0.64–0.98)b | 11 |
Vorticity_LVA−avg (mL/s) | 2269 [1889–3251] (1740–4180)c | 2465 ± 679 (1730–3730) | − 75 ± 511 (− 1270 to 740) | 0.82b | 0.89 (0.53–0.97)b | 11 |