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01.04.2012 | Original Article

Screening for Pancreatic Cancer in a High-Risk Cohort: An Eight-Year Experience

verfasst von: Wigdan Al-Sukhni, Ayelet Borgida, Heidi Rothenmund, Spring Holter, Kara Semotiuk, Robert Grant, Stephanie Wilson, Malcolm Moore, Steven Narod, Kartik Jhaveri, Masoom A. Haider, Steven Gallinger

Erschienen in: Journal of Gastrointestinal Surgery | Ausgabe 4/2012

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Abstract

Background

Pancreatic adenocarcinoma is the fourth leading cause of cancer death.

Methods

A prospective cohort study was undertaken between 2003 and 2011 at a tertiary care centre in Toronto, Canada. Two hundred and sixty-two subjects were enrolled based on an elevated estimated lifetime risk for pancreatic cancer due to known genetic mutations and/or cancer family history. Subjects underwent annual magnetic resonance imaging, followed by additional investigations if abnormal findings were detected. Evidence of malignancy or suspicious macroscopic abnormalities prompted referral for surgical intervention.

Results

Average length of follow-up was 4.2 years, during which 84/262 (32%) subjects demonstrated pancreatic abnormalities. Three participants developed pancreatic adenocarcinoma (one 1.5-cm tumor was resected but recurred, while the other two subjects developed metastatic cancer), and a fourth participant developed a pancreatic neuroendocrine tumor that was resected. Fifteen subjects had radiologic evidence of branch-duct intraductal papillary mucinous neoplasms, of which two underwent surgical resection. Sixty-five subjects had simple pancreatic cysts that have remained stable.

Conclusion

Magnetic resonance imaging can detect small pancreatic tumors and cystic lesions, but further improvement in sensitivity is needed. An understanding of the natural history of pre-invasive lesions in members of high-risk families is necessary for developing a more effective screening program.

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Titel: Screening for Pancreatic Cancer in a High-Risk Cohort: An Eight-Year Experience
verfasst von: Wigdan Al-Sukhni
Ayelet Borgida
Heidi Rothenmund
Spring Holter
Kara Semotiuk
Robert Grant
Stephanie Wilson
Malcolm Moore
Steven Narod
Kartik Jhaveri
Masoom A. Haider
Steven Gallinger
Publikationsdatum: 01.04.2012
Verlag: Springer-Verlag
Erschienen in: Journal of Gastrointestinal Surgery / Ausgabe 4/2012
Print ISSN: 1091-255X
Elektronische ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-011-1781-6

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