Introduction
Materials and Methods
The Patient and her Parents
The Group of Healthy Controls
Determination of PKC Isoenzymes in PBMC
Statistical Analysis
Results
Season Dependent Changes in the Expression of PKC Isoenzymes in PBMC of SLE Patient, in her Parents and Three Healthy Controls
Numeric Data of Densitometry on the Expression of PKC Isoenzymes in PBMC of the Family and Healthy Controls
Seasons | PKC | Father | Mother | Daughter SLE | Daughter SLE treated | Controls (n = 8) |
---|---|---|---|---|---|---|
Summer 1 | α | 1.00 | 0.00 | 0.27 | 0.90 | 1.11 |
β | 1.00 | 0.00 | 0.07 | 0.50 | 1.11 | |
δ | 1.00 | 0.00 | 0.66 | 0.98 | 0.88 | |
η | 1.00 | 0.35 | 0.12 | 0.21 | 0.79 | |
ε | 1.00 | 0.20 | 0.61 | 2.20 | 1.51 | |
θ | 1.00 | 0.00 | 0.29 | 0.58 | 0.84 | |
Average ± SD | „A” 1.00 | „B″ 0.09 ± 0.23 | „C″ 0.33 ± 0.27 | „D” 0.89 ± 0.64 | „E” 1.04 ± 0.27 | |
Winter | α | 2.60 | 2.80 | 1.11 | ||
β | 1.44 | 1.20 | 1.11 | |||
δ | 1.70 | 1.63 | 0.88 | |||
η | 1.54 | 2.10 | 1.51 | |||
ε | 1.05 | 0.66 | 0.79 | |||
θ | 0.98 | 0.50 | 0.84 | |||
Average ± SD | „F″ 1.56 ± 0.59 | „G” 1.48 ± 0.88 | „E” 1.04 ± 0.27 | |||
Summer 2 | α | 0.63 | 0.85 | 1.11 | ||
β | 0.13 | 0.16 | 1.11 | |||
δ | 0.90 | 1.34 | 0.88 | |||
η | 0.72 | 0.74 | 1.51 | |||
ε | 0.09 | 0.30 | 0.79 | |||
θ | 0.11 | 0.09 | 0.84 | |||
Average ± SD | „H″ 0.43 ± 0.36 | „I″ 0.58 ± 0.48 | „E” 1.04 ± 0.27 |
Changes in SLEDAI Values, Serum Levels of Thyroid Hormones along with the MP Treatment of SLE Patient during the Study
Tests/Treatments | July I | September | December | July II |
---|---|---|---|---|
SLEDAI | 14 | 5 | 8 | 3 |
TSH [mU/l] | n.t. | n.t. | 3.6 | 2.3 |
FT4 [pmol/l] | n.t. | n.t. | 17.2 | 14.2 |
FT3 [pmol/l] | n.t. | n.t. | 6.7 | 5.5 |
MP [mg] + other treatments | none | 8 + HC | 8 + HC + AZA | 8 + HC |