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Osteoporosis International

Erschienen in:

01.05.2008 | Short Communication

Seasonal variation of serum α- and β-cryptoxanthin and 25-OH-vitamin D₃ in women with osteoporosis

verfasst von: F. Granado-Lorencio, B. Olmedilla-Alonso, C. Herrero-Barbudo, I. Blanco-Navarro, B. Pérez-Sacristán

Erschienen in: Osteoporosis International | Ausgabe 5/2008

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Abstract

Summary

β-Cryptoxanthin displays a unique anabolic effect on bone calcification. In women with osteoporosis, serum β-cryptoxanthin and 25-OH-vitamin D₃ showed a weak but significant correlation and exhibited a complementary seasonal distribution. The potential role of β-cryptoxanthin as a nutritional approach to improving bone health deserves further evaluation.

Introduction

Dietary intake and serum levels of β-cryptoxanthin have been inversely related to different bone and joint disorders and in vitro and animal studies have shown that β-cryptoxanthin displays a unique anabolic effect on bone calcification. Due to the emerging role of β-cryptoxanthin in bone biology, we aimed to assess the serum distribution and variability of β-cryptoxanthin and their potential relation to 25-OH-vitamin D₃ in women with osteoporosis.

Methods

Serum concentrations of α- and β-cryptoxanthin and 25-OH- D₃ in women with osteoporosis (N = 644) were analyzed using a quality-controlled high-performance liquid chromatography (HPLC) method.

Results

Overall, significant seasonal variations were found for the three analytes and inter-individual variation was also high (60–73%). β-cryptoxanthin and 25-OH-vitamin D₃ exhibited a marked complementary seasonal distribution in serum, with vitamin D displaying the highest values in summer and β-cryptoxanthin in winter.

Conclusions

Given the anabolic effect of β-cryptoxanthin on bone calcification and its complementary seasonal distribution with respect to 25-OH-vitamin D₃, the potential role of β-cryptoxanthin as a sustainable nutritional approach to improving bone health deserves to be further evaluated.

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Titel: Seasonal variation of serum α- and β-cryptoxanthin and 25-OH-vitamin D3 in women with osteoporosis
verfasst von: F. Granado-Lorencio
B. Olmedilla-Alonso
C. Herrero-Barbudo
I. Blanco-Navarro
B. Pérez-Sacristán
Publikationsdatum: 01.05.2008
Verlag: Springer-Verlag
Erschienen in: Osteoporosis International / Ausgabe 5/2008
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-007-0470-5

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Seasonal variation of serum α- and β-cryptoxanthin and 25-OH-vitamin D₃ in women with osteoporosis