Erschienen in:
01.01.2007 | Case Report
Seronegative Sjögren syndrome with asymptomatic autoimmune sclerosing pancreatitis
verfasst von:
Masayuki Matsuda, Hideaki Hamano, Takuhiro Yoshida, Takahisa Gono, Takeshi Uehara, Shigeyuki Kawa, Shu-ichi Ikeda
Erschienen in:
Clinical Rheumatology
|
Ausgabe 1/2007
Einloggen, um Zugang zu erhalten
Abstract
We report two elderly patients with seronegative Sjögren syndrome who showed benign swelling of the pancreas on computed tomography. Immunostaining of the biopsied lip tissue or serum examination confirmed an increase in production of IgG4, leading to a diagnosis of autoimmune sclerosing pancreatitis (ASP) as a cause of the asymptomatic swelling of the pancreas. Sicca symptoms and ASP spontaneously improved in one patient, and the other responded well to oral prednisolone. Seronegative Sjögren syndrome and ASP can concurrently occur as a clinical manifestation of the IgG4-related systemic disorder, particularly in elderly subjects, and, in such a case, corticosteroid may be a potent therapeutic option.