Background
Methods
Selection of patients
Characteristics |
N
| Median (range) | Z |
P
|
---|---|---|---|---|
Sex | 0.936 | 0.349 | ||
Male | 97 | 15.76 (0.11-182.58) | ||
Female | 35 | 21.28 (1.86-171.31) | ||
Age(years) | 0.691 | 0.489 | ||
≥60 | 75 | 15.21 (0.11-182.58) | ||
<60 | 57 | 18.28 (2.59-170.77) | ||
Tumor location | 1.363 | 0.506 | ||
Gastric cardia | 21 | 25.26 (2.47-121.96) | ||
Gastric body | 54 | 14.97 (1.35-182.58) | ||
Gastric antrum | 57 | 17.82 (0.11-158.60) | ||
Tumor size | 3.12 | 0.002 | ||
<5 cm | 85 | 13.96 (0.11-158.60) | ||
≥5 cm | 47 | 28.47 (1.35-182.58) | ||
Lymph node metastasis | 3.392 | 0.001 | ||
Negative | 50 | 10.92 (0.11-144.97) | ||
Positive | 82 | 21.32 (1.35-182.58) | ||
Depth of tumor invasion | 2.039 | 0.041 | ||
pT1-T2 | 35 | 12.22 (1.51-109.66) | ||
pT3-T4 | 97 | 19.65 (0.11-182.58) | ||
Histology differentiation | 1.045 | 0.296 | ||
Differentiated | 67 | 18.28 (1.35-171.31) | ||
Poorly differentiated | 65 | 15.16 (0.11-182.58) | ||
Stage | 3.524 | <0.001 | ||
I + II | 69 | 12.22 (0.11-144.97) | ||
III + IV | 63 | 22.72 (1.35-182.58) |
Sandwich ELISA detection for sB7-H4
Statistical analysis
Results
Analysis of sB7-H4 in gastric cancer patients versus healthy controls
Relationship between sB7-H4 expression and clinicopathological factors in patients with gastric cancer
Relationship between sB7-H4 expression and prognosis
Clinicopathological parameters | Comparison/reference | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|---|
Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
sB7-H4 expression | High/Low | 2.677(1.452-4.934) | 0.002 | 1.925(1.033-3.857) | 0.039 |
Gender | Male/Female | 1.153(0.618-2.148) | 0.655 | 1.194(0.772-1.873) | 0.497 |
Age | <60/≥60 | 0.988(0.962-1.015) | 0.393 | 1.014(0.529-1.384) | 0.859 |
Tumor size | <5 cm/≥5 cm | 2.714(1.536-4.794) | 0.001 | 1.008(0.284-1.637) | 0.359 |
Lymph node metastasis | Positive/Negative | 5.792(2.458-13.644) | <0.001 | 1.623(0.633-2.365) | 0.195 |
Depth of tumor invasion | pT3-T4/pT1-T2 | 2.714(1.536-4.794) | 0.001 | 1.842(0.825-1.972) | 0.156 |
TNM stage | III,IV/I,II | 5.966(2.962-12.013) | <0.001 | 5.184(2.544-10.563) | <0.001 |