nach oben

European Journal of Trauma and Emergency Surgery

Erschienen in:

01.06.2013 | Original Article

Serum cleaved tau protein and traumatic mild head injury: a preliminary study in the Thai population

verfasst von: P. Wuthisuthimethawee, S. Saeheng, T. Oearsakul

Erschienen in: European Journal of Trauma and Emergency Surgery | Ausgabe 3/2013

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To determine the correlation between serum cleaved tau protein and traumatic mild head injury (MHI) (GCS 13–15).

Methods

A prospective observational study was conducted. Blood specimens from 12 healthy persons and 44 adult patients with traumatic MHI were collected in the emergency department to measure the cleaved tau protein level using a Human Tau phosphoSerine 396 ELISA kit. A brain computed tomography (CT) scan was done in all patients. The serum cleaved tau protein level was considered positive at a cut-off point of 0.1 pg/ml. An intracranial lesion was defined as any abnormality detected by brain CT scan.

Results

The mean age of the traumatic MHI patients was 34.9 ± 15.6 years (range 15–74). The median GCS was 15. The median time from injury to arrival at the emergency department was 30 min. There were 11 intracranial lesions detected by brain CT scan (25.0 %). Serum cleaved tau protein was not detected in either healthy or traumatic MHI patients.

Conclusion

As it was uncorrelated with traumatic MHI, serum cleaved tau protein proved to be an unreliable biomarker to use in the early detection of and decision-making for traumatic MHI patients at the emergency department.

Shaw GJ, Jauch EC, Zemlan FP. Serum cleave tau protein levels and clinical outcome in adult patients with closed head injury. Ann Emerg Med. 2002;39:254–7.PubMedCrossRef

Li J, Li XY, Feng DF, Pan DC. Biomarkers associated with diffuse traumatic axonal injury: exploring pathogenesis, early diagnosis, and prognosis. J Trauma. 2010;69:1610–8.PubMedCrossRef

Compagnone C, d’Avella D, Servadei F, Angileri FF, Brambilla G, Conti C, et al. Patients with moderate head injury: a prospective multicenter study of 315 patients. Neurosurgery. 2009;64:690–6.PubMedCrossRef

Haydel MJ, Preston CA, Mills TJ, Luber S, Blaudeau E, Deblieux PMC. Indications for computed tomography in patients with minor head injury. N Eng J Med. 2000;343:100–5.CrossRef

Stiell IG, Wells GA, Vandemheen K, Clement C, Lesiuk H, Laupacis A, et al. The Canadian CT Head Rule for patients with minor head injury. Lancet. 2001;357:1391–6.

Sultan HY, Boyle A, Pereira M, Antoun N, Maimaris C. Application of the Canadian CT head rules in managing minor head injuries in a UK emergency department: implications for the implementation of the NICE guidelines. Emerg Med J. 2004;21:420–5.PubMedCrossRef

Haman SE, Pickering A, Pandor A, Goodacre SW. Clinical decision rules for adults with minor head injury: a systematic review. J Trauma. 2011;71:245–51.CrossRef

Ingebrigtsen T, Waterloo K, Marup-Jensen S, Attner E, Romner B. Quantification of post-concussion symptoms 3 months after minor head injury in 100 consecutive patients. J Neurol. 1998;245:609–12.PubMedCrossRef

Woertgen C, Rothoerl RD, Metz C, Brawanski A. Comparison of clinical, radiologic, and serum marker as prognostic factors after severe head injury. J Trauma. 1999;47:1126–30.PubMedCrossRef

10.

Jönsson H, Johnsson P, Alling C, Bäckström M, Bergh C, Blomquist S. S100beta after coronary artery surgery: release pattern, source of contamination, and relation to neuropsychological outcome. Ann Thorac Surg. 1999;68:2202–8.

11.

Raabe A, Orolms C, Seifert V. Serum markers of brain damage and outcome predictor in patients after severe head injury. Br J Neurosurg. 1999;13(1):56–9.PubMedCrossRef

12.

Herrmann M, Jost S, Kutz S, Ebert AD, Kratz T, Wunderlich MT, et al. Temporal profile of release of neurobiochemical markers of brain damage after traumatic brain injury is associated with intracranial pathology as demonstrated in cranial computerized head tomography. J Neurotrauma. 2000;17:113–22.PubMedCrossRef

13.

Zemlan FP, Rosenberg WS, Luebbe PA, Campbell TA, Dean GE, Weiner NE, et al. Quantification of axonal damage in traumatic brain injury: affinity purification and characterization of cerebrospinal fluid tau protein. J Neurochem. 1999;72:741–50.PubMedCrossRef

14.

Lang E, Otvos L. A serine → proline change in the Alzheimer’s disease-associated epitope tau 2 results in altered secondary structure, but phosphorylation overcomes the conformational GAP. Biochem Biophys Res Commun. 1992;88(1):162–9.

15.

Gabbita SP, Scheff SW, Menard RM, Roberts K, Fugaccia I, Zemlan FP. Cleaved-tau: a biomarker of neuronal damage after traumatic brain injury. J Neurotrauma. 2005;22:83–94.PubMedCrossRef

16.

Zemlan FP, Jauch EC, Mulchahey JJ, Gabbita SP, Rosenberg WS, Speciale SG, et al. C-tau biomarkers of neuronal damage in severe brain injured patients: association with elevated intracranial pressure and clinical outcome. Brain Res. 2002;947:131–9.

17.

Shiiya N, Kunihara T, Miyatake T, Maysuzaki K, Yasuda K. Tau protein in the cerebrospinal fluid in a marker of brain injury after aortic surgery. Ann Thorac Surg. 2004;77:2034–8.PubMedCrossRef

18.

Liliang PC, Liang CL, Lu K, Wang KW, Weng HC, Hsieh CH, et al. Relationship between injury severity and serum tau protein levels in traumatic brain injured rats. Resuscitation. 2010;81:1205–8.PubMedCrossRef

19.

Ost M, Nylen K, Csajbok L, Ohrfelt AO, Tullberg M, Wikkelso C, et al. Initial CSF total tau correlates with 1-year outcome in patients with traumatic brain injury. Neurology. 2006;67:1600–4.PubMedCrossRef

20.

Bulut M, Koksal O, Dogan S, Bolca N, Ozguc H, Korfali E, et al. Tau protein as a serum marker of brain damage in mild traumatic brain injury: preliminary results. Adv Ther. 2006;23:12–22.PubMedCrossRef

21.

Kavalci C, Pekdemir M, Durukan P, Lihan N, Yildiz M, Serhatlioglu S, et al. The value of serum taum protein for the diagnosis of intracranial injury in minor head trauma. Am J Emerg Med. 2007;25:391–5.PubMedCrossRef

22.

Guzel A, Karasalihoglu S, Aylanc H, Temizoz O, Hicdonmez T. Validity of serum tau protein levels in pediatric patients with minor head trauma. Am J Emerg Med. 2010;28:399–403.PubMedCrossRef

23.

Liliang PC, Liang CL, Weng HC, Lu K, Wang KW, Chen HC, et al. Tau proteins in serum predict outcome after severe traumatic brain injury. J Surg Res. 2010;160:302–7.PubMedCrossRef

24.

Ma M, Lindsell CJ, Rosenberry CM, Shaw GJ, Zemlan FP. Serum cleaved tau does not predict postconcussion syndrome after mild traumatic brain injury. Am J Emerg Med. 2008;26:763–8.PubMedCrossRef

25.

Bazarian JJ, Zemlan FP, Mookerjee S, Stigbrand T. Serum S-100B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury. Brain Inj. 2006;20:759–65.PubMedCrossRef

26.

Begaz T, Kyriacou DN, Segal J, Bazarian JJ. Serum biochemical markers for post-concussion syndrome in patients with mild traumatic brain injury. J Neurotrauma. 2006;23:1201–10.PubMedCrossRef

Titel: Serum cleaved tau protein and traumatic mild head injury: a preliminary study in the Thai population
verfasst von: P. Wuthisuthimethawee
S. Saeheng
T. Oearsakul
Publikationsdatum: 01.06.2013
Verlag: Springer-Verlag
Erschienen in: European Journal of Trauma and Emergency Surgery / Ausgabe 3/2013
Print ISSN: 1863-9933
Elektronische ISSN: 1863-9941
DOI: https://doi.org/10.1007/s00068-013-0263-9

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen.
» Jetzt entdecken

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Arthroskopie kann Knieprothese nicht hinauszögern

25.04.2024 Gonarthrose Nachrichten

Ein arthroskopischer Eingriff bei Kniearthrose macht im Hinblick darauf, ob und wann ein Gelenkersatz fällig wird, offenbar keinen Unterschied.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Ärztliche Empathie hilft gegen Rückenschmerzen

23.04.2024 Leitsymptom Rückenschmerzen Nachrichten

Personen mit chronischen Rückenschmerzen, die von einfühlsamen Ärzten und Ärztinnen betreut werden, berichten über weniger Beschwerden und eine bessere Lebensqualität.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2013

Influence of implant design on the method of failure for three implants designed for use in the treatment of intertrochanteric fractures: the dynamic hip screw (DHS), DHS blade and X-BOLT

Feed the gut, feed early and with the right stuff, but do not forget total parenteral nutrition

Severe trauma of the chest wall: surgical rib stabilisation versus non-operative treatment

Does the ratio and thickness of prevertebral soft tissue provide benefit in blunt cervical spine injury?

Gastrointestinal tract access for enteral nutrition in critically ill and trauma patients: indications, techniques, and complications

Nutritional support in patients following damage control laparotomy with an open abdomen