Erschienen in:
01.08.2012 | Clinical Research
Serum Insulin-Like Growth Factor-1 Concentrations Are Reduced in Severely Obese Women and Raise After Weight Loss Induced by Laparoscopic Adjustable Gastric Banding
verfasst von:
Giulia Galli, Aldo Pinchera, Paolo Piaggi, Paola Fierabracci, Monica Giannetti, Giorgia Querci, Giovanni Scartabelli, Luca Manetti, Giovanni Ceccarini, Silvia Martinelli, Claudio Di Salvo, Marco Anselmino, Fausto Bogazzi, Alberto Landi, Paolo Vitti, Margherita Maffei, Ferruccio Santini
Erschienen in:
Obesity Surgery
|
Ausgabe 8/2012
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Abstract
Background
Obesity is associated with abnormalities of the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis. The role of serum IGF-1 measurement for recognition of hypothalamic–pituitary diseases in obesity is still a matter of debate.
Methods
This study evaluated the serum levels of IGF-1 in a population of severely obese women before and after long-term weight loss obtained by laparoscopic adjustable gastric banding (LAGB). Eighty obese women with body mass index (BMI) of more than 34 kg/m2 and 80 unrelated age-matched lean controls were enrolled. IGF-1 serum levels were measured together with BMI, liver volume, and intra-abdominal fat thickness assessed by ultrasound. Evaluation was repeated 2 years after LAGB.
Results
Our results showed that mean IGF-1 levels in obese subjects before LAGB were significantly lower (p < 0.001) than that observed in age-matched controls. Age and BMI were independent predictors of serum IGF-1 values, overall accounting for 39 % of IGF-1 variability. The mean IGF-1 concentration significantly increased 2 years after LAGB. BMI reduction was independently associated with IGF-1 increase (r = −0.29, p < 0.001). For each point of BMI reduction, the mean increase of serum IGF-1 was 4.39 ng/mL.
Conclusions
(1) Severely obese women have low IGF-1 serum levels with respect to normal weight age-matched controls; (2) the extent of IGF-1 deficiency is proportional to increased BMI; (3) after LAGB a spontaneous raise of serum IGF-1 occurs, proportional to the extent of weight reduction; and (4) serum IGF-1 in severely obese subjects may have a limited value for detection of hypothalamic–pituitary diseases.