Erschienen in:
21.08.2018 | Letter to the Editor
Serum or Plasma Matrix Metalloproteinase (MMP)-9 Levels and Cardiovascular Diseases
verfasst von:
Indiara V. Santana, Jose E. Tanus-Santos
Erschienen in:
Journal of Cardiovascular Translational Research
|
Ausgabe 6/2018
Einloggen, um Zugang zu erhalten
Excerpt
Matrix metalloproteinases (MMP) are a group of zinc-dependent enzymes that are critically involved in degrading components of the extracellular matrix during physiological and pathological processes. Of particular importance, altered expression or activity of MMP-9 has been reported in a variety of pathological conditions including cardiovascular diseases [
1]. In this respect, the circulating concentration of MMP-9 has been consistently suggested as a biomarker of disease with diagnostic and prognostic value. In addition, the circulating levels of endogenous inhibitors of MMPs, the tissue inhibitors of MMPs (TIMPs) have also been assessed to provide improved information regarding tissue or circulating MMP activity in disease conditions [
1]. However, some pre-analytical pitfalls of blood sampling may limit the utility of this approach. …