nach oben

Clinical Rheumatology

Erschienen in:

09.01.2018 | Original Article

Severity of symptoms persists for decades in fibromyalgia—a 26-year follow-up study

verfasst von: Risto Isomeri, Marja Mikkelsson, Markku Partinen, Markku J. Kauppi

Erschienen in: Clinical Rheumatology | Ausgabe 5/2018

Einloggen, um Zugang zu erhalten

Abstract

The aim of this study is to find out the outcome of 28 patients who got the diagnosis of primary fibromyalgia (pFM) 26 years ago. In 1986, 56 patients with widespread pain were examined and filled in a base questionnaire (BQ). Of them, 42 fulfilled the Yunus criteria for pFM. Twenty-six years later, addresses of 38 patients were found, and an extensive follow-up questionnaire (FupQ) was mailed to them. Of them, 28 (74%) answered the FupQ. This included nine identical questions with the BQ and questions concerning changes in their symptoms and quality of life (Qol). Three patients (11%) had healed from fibromyalgia (FM), and 23% reported having one or several symptomless periods lasting at least 1 year. In others (n = 25), all but pain and ache showed slight deterioration. Despite the aging and FM, the level of functional ability evaluated by Stanford Health Assessment Questionnaire (HAQ) remained at the same level (BQ 0.41 vs. Fup 0.44, p = 0.82). The sum score of reported symptoms (n = 21) did not change significantly (10.8 (SD 2.9) vs. 11.1 (SD 4.1), p = 0.75). Experienced sleeplessness increased most significantly (27 vs. 65%, p = 0.0034). Exercising did not have a significant influence on the changes of the measured parameters. However, the three healed patients exercised regularly. Symptoms of FM have persisted in most patients for decades without significant deterioration of self-reported functional ability. About one fourth of patients had experienced long symptomless periods during their illness. Three patients (11%) reported that they have healed from FM.

Yunus MB (2015) Editorial review: an update on central sensitivity syndromes and the issues of nosology and psychobiology. Curr Rheumatol Ref 11(2):70–85. https://doi.org/10.2174/157339711102150702112236 CrossRef

Boomershine CS (2015) Fibromyalgia: the prototypical central sensitivity syndrome. Curr Rheumatol Rev 11(2):131–145. https://doi.org/10.2174/1573397111666150619095007 CrossRefPubMed

Bengtsson A, Bäckman E, Lindblom B, Skogh T (1994) Long term follow-up of fibromyalgia patients: clinical symptoms, muscular function, laboratory tests – an eight year comparison study. J Musculoskeletal Pain 2(2):67–80CrossRef

Kennedy M, Fleson DT (1996) A prospective long-term study of fibromyalgia syndrome. Arthritis Rheum 39(4):682–685. https://doi.org/10.1002/art.1780390422 CrossRefPubMed

Wolfe F, Anderson J, Harkness D, Bennett RM, Caro XJ, Goldenberg DL, Russell IJ, Yunus MB (1997) Health status and disease severity in fibromyalgia: results of a six-center longitudinal study. Arthritis Rheum 40(9):1571–1579. https://doi.org/10.1002/art.1780400905 CrossRefPubMed

Mengshoel AM, Haugen M (2001) Health status in fibromyalgia—a followup study. Rheumatol 28:2085–2089

Baumgartner E, Finckh A, Cedrashi C, Visher TL (2002) A six year prospective study of a cohort of patients with fibromyalgia. Ann Rheum Dis 61(7):644–645. https://doi.org/10.1136/ard.61.7.644 CrossRefPubMedPubMedCentral

White DH, Faull K, Jones PB (2009) An exploratory study of long-term health outcomes following an in-patient multidisciplinary program for people with fibromyalgia syndrome. Int J Rheum Dis 12(1):52–56. https://doi.org/10.1111/j.1756-185X.2009.01380.x CrossRefPubMed

Walitt B, Fitzcharles MA, Hassett AL, Katz RS, Häuser W, Wolfe F (2011) The longitudinal outcome of fibromyalgia: a study of 1555 patients. J Rheumatol 38(10):2238–2246. https://doi.org/10.3899/jrheum.110026 CrossRefPubMed

10.

Kashikar-Zuck S et al (2014) Long term outcomes of adolescents with juvenile-onset fibromyalgia in early adulthood. Pediatrics 133(3):592–600CrossRef

11.

Markkula R, Kalso E, Huunan-Seppälä A, Koskenvuo M, Koskenvuo K, Leino-Arjas P, Kaprio J (2011) The burden of symptoms predicts early retirement: a twin cohort study on fibromyalgia-associated symptoms. Eur J Pain 15(7):741–747. https://doi.org/10.1016/j.ejpain.2011.01.004 CrossRefPubMed

12.

Wolfe F, Hasset AL, Wallit B, Michaud K (2011) Mortality in fibromyalgia: a study of 8,186 patients over thirty-five years. Arthritis Care Res (Hoboken) 63(1):95–101CrossRef

13.

Yunus MF, Masi AT, Calabro JJ, Miller KA, Feigenbaum SL (1981) Primary fibromyalgia (fibrositis). Clinical study of 50 patients with matched normal controls. Semin Arthritis Rheum 11(1):151–171. https://doi.org/10.1016/0049-0172(81)90096-2 CrossRefPubMed

14.

Fries JF, Spitz PW, Kraines RG (1980) Measurement of patient outcome in arthritis. Arthritis Rheum 23(2):137–145. https://doi.org/10.1002/art.1780230202 CrossRefPubMed

15.

Keltikangas-Järvinen L, Rimon R (1987) Rimon’s brief depression scale, a rapid method for screening depression. Psychol Rep 60(1):111–119. https://doi.org/10.2466/pr0.1987.60.1.111 CrossRefPubMed

16.

Gauffin J, Hankama T, Kautiainen H, Arkela-Kautiainen M, Hannonen P, Haanpää M (2012) Validation of a Finnish version of the Fibromyalgia Impact Questionnaire (Finn- FIQ). Scand J Pain 3:15–20CrossRef

17.

Vainiola T, Pettilä V, Roine RP, Räsänen P, Rissanen AM, Sintonen H (2010) Comparison of two utility instruments, the EQ-5D and the 15D, in the critical care setting. Intensive Care Med 36(12):2090–2093. https://doi.org/10.1007/s00134-010-1979-1 CrossRefPubMedPubMedCentral

18.

Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P, Fam AG, Farber SJ, Fiechtner JJ, Michael Franklin C, Gatter RA, Hamaty D, Lessard J, Lichtbroun AS, Masi AT, Mccain GA, John Reynolds W, Romano TJ, Jon Russell I, Sheon RP (1990) The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 33(2):160–172. https://doi.org/10.1002/art.1780330203 CrossRefPubMed

19.

Granges G, Zilko P, Littlejohn GO (1994) Fibromyalgia syndrome: assessment of the severity of the condition 2 years after diagnosis. J Rheumatol 21(3):523–529PubMed

20.

Henriksson CM (1994) Longterm effects of fibromyalgia on everyday life. A study of 56 patients. Scand J Rheumatol 23(1):36–41. https://doi.org/10.3109/03009749409102133 CrossRefPubMed

21.

Fitzcharles MA, Costa DD, Pöyhiä R (2003) A study of standard care in fibromyalgia syndrome: a favorable outcome. J Rheumatol 30(1):154–159PubMed

22.

Viola-Saltzman M, Watson NF, Bogart A, Goldberg J, Buchwald D (2010) High prevalence on restless legs syndrome among patients with fibromyalgia: a controlled cross-sectional study. J Clin Sleep Med 15:423–427

23.

Bjorvatn B, Leissner L, Ulfberg J et al (2005) Prevalence, severity and risk factors of restless legs syndrome in the general adult population in two Scandinavian countries. Sleep Med 6(4):307–312. https://doi.org/10.1016/j.sleep.2005.03.008 CrossRefPubMed

24.

Guedji D, Weinberger A (1990) Effect of weather conditions on rheumatic patients. Ann Rheum Dis 49(3):158–159. https://doi.org/10.1136/ard.49.3.158 CrossRef

25.

Miranda LS et al (2007) Perceived pain and weather changes in rheumatic patients. Acta Reumatol Port 32(4):351–361PubMed

26.

Smedslund G, Eide H, Kristjansdottir OB, Nes AA, Sexton H, Fors EA (2014) Do weather changes influence pain levels in women with fibromyalgia, and can psychosocial variables moderate these influences? Int J Biometeorol 58(7):1451–1457. https://doi.org/10.1007/s00484-013-0747-7 CrossRefPubMed

27.

Fors EA, Sexton H (2002) Weather and the pain in fibromyalgia: are they related? Ann Rheum Dis 61(3):247–250. https://doi.org/10.1136/ard.61.3.247 CrossRefPubMedPubMedCentral

28.

Isomäki H (1988) The sauna and rheumatic diseases. Ann Clin Res 20(4):271–275PubMed

29.

Hasset AL, Clauw D (2010) The role of stress in rheumatic diseases. Arthritis Res Ther 12(3):123. https://doi.org/10.1186/ar3024 CrossRef

30.

Bidonde J, Busch AJ, Bath B, Milosavljevic S (2014) Exercise for adults with fibromyalgia: an umbrella systematic review with synthesis of best evidence. Curr Rheumatol Rev 10(1):45–79. https://doi.org/10.2174/1573403X10666140914155304 CrossRefPubMed

31.

Ellingson LD, Stegner AJ, Schwabacher IJ, Koltyn KF, Cook DB (2016) Exercise strengthens central nervous system modulation of pain in fibromyalgia. Brain Sci 6(1). https://doi.org/10.3390/brainsci6010008

Titel: Severity of symptoms persists for decades in fibromyalgia—a 26-year follow-up study
verfasst von: Risto Isomeri
Marja Mikkelsson
Markku Partinen
Markku J. Kauppi
Publikationsdatum: 09.01.2018
Verlag: Springer London
Erschienen in: Clinical Rheumatology / Ausgabe 5/2018
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-017-3967-0

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Severity of symptoms persists for decades in fibromyalgia—a 26-year follow-up study

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Proximale Humerusfraktur: Auch 100-Jährige operieren?

Die „Zehn Gebote“ des Endokarditis-Managements

Strenge Blutdruckeinstellung lohnt auch im Alter noch

Dihydropyridin-Kalziumantagonisten können auf die Nieren gehen

Update Innere Medizin

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2018

Secretory sphingomyelinase (S-SMase) activity is elevated in patients with rheumatoid arthritis

Regional differences in baseline disease activity and remission rates following golimumab treatment for RA: results from the GO-MORE trial

Anti-adalimumab antibodies in a cohort of patients with juvenile idiopathic arthritis: incidence and clinical correlations

Demographic and clinical characteristics of patients with serum sickness-like reaction

Unexplained cough: it is time to rule out Sjogren’s syndrome

Long-term disease and patient-reported outcomes of a continuous treat-to-target approach in patients with early rheumatoid arthritis in daily clinical practice

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Proximale Humerusfraktur: Auch 100-Jährige operieren?

Die „Zehn Gebote“ des Endokarditis-Managements

Strenge Blutdruckeinstellung lohnt auch im Alter noch

Dihydropyridin-Kalziumantagonisten können auf die Nieren gehen

Update Innere Medizin