Erschienen in:
01.08.2017 | Editorial
Sex difference in cardiac metabolism in nonischemic heart failure: Insight for prognostic value of altered cardiac metabolism
verfasst von:
Hyung-Jun Im, MD, PhD, Gi Jeong Cheon, MD, PhD
Erschienen in:
Journal of Nuclear Cardiology
|
Ausgabe 4/2017
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Excerpt
Heart has the highest metabolic demands than any other organs. To maintain contractile function of the heart, constant and rapid production of adenosine triphosphate (ATP) is needed. Fatty acid (FA) and glucose are the main fuels for production of the ATPs by mitochondrial oxidative phosphorylation. In normal condition, 60% to 90% of total ATP is made from FA and the other from glucose or lactate. In a failing heart, cardiac metabolism is profoundly altered, and majority of the studies suggest that FA metabolism decreases. However, it is not clear and still in controversy whether the alteration in cardiac metabolism in a failing heart is an adaptation or maladaptation.
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