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12.01.2023 | Original Article

Sex differences in estimates of cardiac autonomic function using heart rate variability: effects of dietary capsaicin

verfasst von: Kendall S. Zaleski, Abena O. Gyampo, Brian Lora, Tawn Tomasi, Meaghan Lynch, Gaia Giuriato, Emma Basso, Emma Finegan, Jack Schickler, Massimo Venturelli, Justin DeBlauw, Stephen J. Ives

Erschienen in: European Journal of Applied Physiology | Ausgabe 5/2023

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Abstract

Purpose

Heart rate variability (HRV) estimates the autonomic nervous system (ANS) influence on the heart and appears sex-specific. Sensory afferents exhibit sex-specificity; although, it is unknown if Capsaicin, an agonist for transient receptor potential vanilloid channel-1 (TRPV₁), alters cardiac ANS activity in a sex-dependent manner, which could be important given the predictive nature of HRV on risk of developing hypertension. Thus, we explored if there was sex-specificity in the effect of capsaicin on estimated cardiac ANS activity.

Methods

HRV was measured in 38 young males (M: n = 25) and females (F: n = 13), in a blinded-crossover design, after acute ingestion of placebo or capsaicin. Resting HR, RR-interval, root-mean-square of successive differences (RMSSD), natural log-transformed RMSSD (LnRMSSD), standard deviation of n–n intervals (SDNN), number of pairs of successive n–n intervals differing by > 50 ms (NN50), and percent NN50 (PNN50) were obtained using standard techniques.

Results

Significant sex differences were observed in mean HR (M: 59 ± 9.3 vs. F: 65 ± 12 beats/min, p = 0.036, η² = 0.098), minimum HR (M: 47 ± 8.3 vs. F: 56 ± 12 beats/min, p = 0.014, η² = 0.124), and NN50 (M: 177 ± 143 vs. F: 29 ± 17, p < 0.001, η² = 0.249). There was a significant interaction of sex*treatment (p = 0.02, η² = 0.027) for RMSSD, where males increased (78 ± 55 vs. 91 ± 64 ms), and females decreased (105 ± 83 vs. 76 ± 43 ms), placebo vs. capsaicin.

Conclusion

This controlled study recapitulates sex differences in HR and HRV, but revealed a sexual dimorphism in the parasympathetic response to capsaicin, perhaps due to differing TRPV₁-afferent sensitivity, highlighting a potential mechanism for differential regulation of hemodynamics, and CVD risk, and should be considered in future studies.

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Titel: Sex differences in estimates of cardiac autonomic function using heart rate variability: effects of dietary capsaicin
verfasst von: Kendall S. Zaleski
Abena O. Gyampo
Brian Lora
Tawn Tomasi
Meaghan Lynch
Gaia Giuriato
Emma Basso
Emma Finegan
Jack Schickler
Massimo Venturelli
Justin DeBlauw
Stephen J. Ives
Publikationsdatum: 12.01.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 5/2023
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-023-05136-0

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Springer Medizin

Sex differences in estimates of cardiac autonomic function using heart rate variability: effects of dietary capsaicin

Abstract

Purpose

Methods

Results

Conclusion

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Das Geschlechterparadoxon in der gesundheitlich beeinträchtigten Lebenszeit – Ende eines Mythos?

Gesunde Lebenserwartung: Ein kritischer Blick auf Nutzen und Potenziale des demographischen Gesundheitsindikators

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Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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