Background
Methods
Ethical approval
Statistical analyses
Results
Distribution by register, sex and TKA | DTR | DKR | |
Number | 92,748 | 51,775 | |
Females | 46,171 | 32,076 | |
Males | 46,577 | 19,699 | |
Record in DKR | 674a (85) | 41,645 (81) | |
Females | 349 (61) | 26,719 (62) | |
Males | 227 | 15,111 | |
Mean age (years) | 67.1 (39–94) | 67.6 (17–100) | |
Females | 67.7 (40–94) | 68.3 (17–100) | |
Males | 66.3 (39–88) | 66.3 (21–96) | |
Distribution by zygosity, sex and TKA | Males | Females | Total by sex |
MZ with TKA | 39 | 82 (68) | 121 |
MZ without TKA | 9,739 | 10,135 (51) | 19,874 |
DZ with TKA | 103 | 157 (60) | 260 |
DZ without TKA | 17,727 | 16,691 (48) | 34,418 |
OS with TKA | 85 | 110 (56) | 195 |
OS without TKA | 18,884 | 18,996 (50) | 37,880 |
Total | 46,577 | 46,171 (50) | 92,748 |
Tetrachoric correlations
Zygosity | Concordant TKA due to OA pairs (n) | Discordant TKA due to OA pairs (n) | Concordant pairs without OA pairs (n) | Tetrachoric correlation (rho) (p valuea) |
---|---|---|---|---|
MZ males | 1 | 29 | 4509 | 0.45 (0.05) |
DZ males | 4 | 72 | 8176 | 0.51 (<0.0001) |
MZ females | 10 | 52 | 4701 | 0.73 (<0.0001) |
DZ females | 6 | 122 | 7575 | 0.42 (<0.0001) |
OS-DZ | 3 | 158 | 17,490 | 0.36 (0.004) |
Cumulative incidence function
Proband-wise concordance rates on age
Prevalences, tetrachoric correlations and case-wise concordance rates
Model in males | MZ prevalence | DZ prevalence | MZ rho | DZ rho | MZ cwc | DZ cwc | H | Variance component estimates | Chi-square test statistics | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A | D | C | E | LL | –2ln | df |
p value | AIC | ||||||||
Sat | 0.02 (0.01–0.02) | 0.02 (0.01–0.02) | 0.66 (0.03–0.92) | 0.71 (0.39–0.87) | 0.26 (0.05–0.70) | 0.30 (0.13–0.55) | 0 (0.00–0.89) | – | – | – | – | –3387.1 | 0.021 | 1 | Compare CE, p = 0.65 | 6780.14 |
ACE | 0.02 (0.01–0.02) | 0.02 (0.01–0.02) | 0.7 (0.42–0.85) | 0.7 (0.42–0.85) | 0.29 (0.14–0.51) | 0.29 (0.14–0.51) | 0 | 0 | – | 0.69 (0.48–0.90) | 0.31 (0.1–0.52) | –3387.2 | 25.8 | 1 | Compared AE, p <0.0001 | 6780.35 |
ADE | 0.02 (0.01–0.02) | 0.02 (0.01–0.02) | 0.79 (0.45–0.93) | 0.39 (0.28–0.50) | 0.39 (0.18–0.66) | 0.10 (0.07–0.16) | 0.79 (0.57–1.0) | 0.79 (0.57–1.0) | 0 | – | 0.21 (0.0–0.43) | –3400.1 | 0 | 1 | Compare DE, p = 1.0 | 6806.14 |
AE | 0.02 (0.01–0.02) | 0.02 (0.01–0.02) | 0.79 (0.45–0.93) | 0.39 (0.28–0.50) | 0.39 (0.18–0.66) | 0.10 (0.07–0.16) | 0.79 (0.57–1.0) | 0.79 (0.57–1.0) | – | – | 0.21 (0.0–0.43) | –3400.1 | 25.8 | 1 | Compare Sat, p <0.0001 | 6804.14 |
CE
|
0.02 (0.01–0.02)
|
0.02 (0.01–0.02)
|
0.69 (0.42–0.85)
|
0.69 (0.42–0.85)
|
0.29 (0.14–0.51)
|
0.29 (0.14–0.51)
|
–
|
–
|
_
|
0.69 (0.48–0.90)
|
0.31 (0.1–0.52)
|
–3387.2
|
0
|
1
|
Compare ACE,
p
= 1.0
|
6778.35
|
DE | 0.02 (0.01–0.02) | 0.02 (0.01–0.02) | 0.76 (0.38–0.92) | 0.19 (0.13–0.25) | 0.36 (0.14–0.66) | 0.04 (0.03–0.06) | 0.76 (0.51–1.0) | – | 0.76 (0.51–1.0) | – | 0.24 (0.00–0.49) | –3414.6 | 29.1 | 1 | Compare ADE, P <0.0001 | 6833.24 |
Model in females | MZ prevalence | DZ prevalence | MZ rho | DZ rho | MZ cwc | DZ cwc | H | Variance component estimates | Chi-square test statistics | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A | D | C | E | LL | –2ln | df |
p value | AIC | ||||||||
Sat | 0.03 (0.03–0.04) | 0.03 (0.03–0.04) | 0.77 (0.53–0.90) | 0.74 (0.48–0.88) | 0.42 (0.25–0.62) | 0.39 (0.22–0.60) | 0.06 (0.0–0.58) | – | – | – | – | –5877.6 | 34.2 | 1 | Compare AE, p <0.0001 | 11,552.2 |
ACE
|
0.03 (0.03–0.04)
|
0.03 (0.03–0.04)
|
0.77 (0.53–0.90)
|
0.74 (0.48–0.88)
|
0.42 (0.25–0.62)
|
0.39 (0.22–0.60)
|
0.06 (0.0–0.58)
|
0.06 (0.0–0.58)
|
–
|
0.71 (0.29–1.00)
|
0.23 (0.06–0.41)
|
–5877.6
|
34.2
|
1
|
Compare AE,
p
<0.0001
|
11,552.2
|
ADE | 0.03 (0.03–0.04) | 0.03 (0.03–0.04) | 0.80 (0.62–0.91) | 0.40 (0.33–0.47) | 0.46 (0.30–0.63) | 0.15 (0.12–0.19) | 0.80 (0.67–0.94) | 0.80 (0.67–0.94) | 0 | – | 0.20 (0.06–0.33) | –5894.8 | 0 | 1 | Compare AE, p = 1.0 | 11,575.6 |
AE | 0.03 (0.03–0.04) | 0.03 (0.03–0.04) | 0.80 (0.62–0.91) | 0.40 (0.33–0.47) | 0.46 (0.30–0.63) | 0.15 (0.12–0.19) | 0.80 (0.67–0.94) | 0.80 (0.67–0.94) | – | – | 0.20 (0.06–0.33) | –5894.8 | 23.3 | 1 | Compare Sat, p <0.0001 | 11,573.6 |
CE | 0.03 (0.03–0.04) | 0.03 (0.03–0.04) | 0.76 (0.60–0.86) | 0.76 (0.60–0.86) | 0.41 (0.28–0.55) | 0.41 (0.28–0.55) | – | – | _ | 0.76 (0.63–0.88) | 0.24 (0.12–0.37) | –5877.7 | 0.26 | 1 | Compare ACE, p = 0.61 | 11,553.5 |
DE | 0.03 (0.03–0.04) | 0.03 (0.03–0.04) | 0.79 (0.59–0.90) | 0.20 (0.16–0.24) | 0.45 (0.38–0.63) | 0.08 (0.06–0.09) | 0.79 (0.64–0.94) | – | 0.79 (0.64–0.94) | – | 0.19 (0.05–0.33) | –5912.5 | 35.5 | 1 | Compare ADE, p <0.0001 | 11,606.5 |
Model | MZ prevalence | DZ prevalence | MZ rho | DZ rho | MZ cwc | DZ cwc | H | Variance component estimates | Chi-square test statistics | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A | D | C | E | LL | –2ln | df |
p value | AIC | ||||||||
Sat | 0.03 (0.03–0.04) | 0.03 (0.03–0.04) | 0.79 (0.59–0.90) | 0.70 (0.50–0.83) | 0.44 (0.28–0.62) | 0.35 (0.22–0.51) | 0.18 (0.00–0.62) | – | – | – | – | –10014.6 | 3.87 | 1 | Compare CE, p = 0.05 | 20,037.10 |
ACE
|
0.03 (0.03–0.04)
|
0.03 (0.03–0.04)
|
0.79 (0.59–0.90)
|
0.70 (0.50–0.83)
|
0.44 (0.28–0.62)
|
0.35 (0.22–0.51)
|
0.18 (0.0–0.62)
|
0.18 (0.0–0.62)
|
–
|
0.61 (0.25–0.97)
|
0.21 (0.06–0.36)
|
–10014.5
|
44.6
|
1
|
Compare AE,
p
<0.0001
|
20,037.10
|
ADE | 0.03 (0.03–0.04) | 0.03 (0.03–0.04) | 0.83 (0.68–0.91) | 0.41 (0.36–0.47) | 0.49 (0.35–0.64) | 0.16 (0.13–0.19) | 0.83 (0.72–0.94) | 0.83 (0.72–0.94) | 0 | – | 0.17 (0.06–0.28) | –10036.8 | 0 | 1 | Compare AE, p = 1.0 | 20,081.66 |
AE | 0.03 (0.03–0.04) | 0.03 (0.03–0.04) | 0.83 (0.68–0.91) | 0.41 (0.36–0.47) | 0.49 (0.35–0.64) | 0.16 (0.13–0.19) | 0.83 (0.72–0.94) | 0.83 (0.72–0.94) | – | – | 0.17 (0.06–0.28) | –10036.8 | 34.3 | 1 | Compared ACE, p <0.0001 | 20,079.66 |
CE | 0.03 (0.03–0.04) | 0.03 (0.03–0.04) | 0.74 (0.61–0.83) | 0.74 (0.61–0.83) | 0.39 (0.29–0.51) | 0.39 (0.29–0.51) | – | – | – | 0.74 (0.63–0.85) | 0.26 (0.15–0.37) | –10016.5 | 3.87 | 1 | Compare ACE, p = 0.05 | 20,038.97 |
DE | 0.03 (0.03–0.04) | 0.03 (0.03–0.04) | 0.82 (0.66–0.91) | 0.20 (0.17–0.23) | 0.48 (0.33–0.63) | 0.08 (0.07–0.09) | 0.81 (0.70–0.94) | – | 0.82 (0.70–0.94) | – | 0.18 (0.06–0.30) | –10067.7 | 61.7 | 1 | Compare ADE, p <0.0001 | 20,141.35 |