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Neurological Sciences
Erschienen in: Neurological Sciences 1/2014

01.05.2014 | ORAL COMMUNICATIONS

Sex-related differences in migraine

verfasst von: Cinzia Finocchi, Laura Strada

Erschienen in: Neurological Sciences | Sonderheft 1/2014

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Abstract

This paper reviews sex-related differences in migraine epidemiology, symptoms, natural history and co-morbid disorders. Migraine is more than twice as common in females as in males, and women experience more frequent, longer lasting and more painful attacks, have more disability and a risk of transition from episodic to chronic migraine greater than men, but the mechanisms behind these differences are still poorly understood. The role of sex hormones, genes, and the differences in brain function and structure are discussed. Finally, we evaluate the many gender-related questions about treatment of migraine in women. In future research data should be analyzed separately for men and women to ensure that differences between the sexes could be identified.
Literatur
1.
Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL 3rd (2009) Sex, gender, pain: a review of recent clinical and experimental findings. J Pain 10:447–485PubMedCentralPubMedCrossRef
2.
Stewart WF, Wood C, Reed ML, Roy J, Lipton RB (2008) Cumulative lifetime migraine incidence in women and men. Cephalalgia 28:1170–1178PubMedCrossRef
3.
Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M (2001) Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 41:646–657PubMedCrossRef
4.
FerranteT Castellini P, Abrignani G, Latte L, Russo M, Camarda C, Veronesi L, Pasquarella C, Manzoni GC, Torelli P (2012) The PACE study: past-year prevalence of migraine in Parma’s adult general population. Cephalalgia 32(5):358–365CrossRef
5.
Bille B (1962) Migraine in school children. Acta Paediatr Scand 51:1–151CrossRef
6.
MacGregor EA, Rosenberg JD, Tobias Kurth T (2011) Sex-related differences in epidemiological and clinic-based headache studies. Headache 51:843–859PubMedCrossRef
7.
Lipton RB, Bigal ME, Diamond M, Freitag F, Reed ML, Stewart WF (2007) Migraine prevalence, disease burden, and the need for preventive therapy. Neurology 68:343–349PubMedCrossRef
8.
Stewart WF, Linet MS, Celentano DD, Van Natta M, Ziegler D (1991) Age- and sex-specific incidence rates of migraine with and without visual aura. Am J Epidemiol 134:1111–1120PubMed
9.
Hu XH, Markson LE, Lipton RB, Stewart WF, Berger M (1999) Burden of migraine in the United States: disability and economic costs. Arch Intern Med 159:813–818PubMedCrossRef
10.
Boardman HF, Thomas E, Croft PR, Millson DS (2003) Epidemiology of headache in an English district. Cephalalgia 23:129–137PubMedCrossRef
11.
Granella F, Sances G, Allais G, Nappi RE, Tirelli A, Benedetto C et al (2004) Characteristics of menstrual and nonmenstrual attacks in women with menstrually related migraine referred to headache centres. Cephalalgia 24:707–716PubMedCrossRef
12.
Burstein R, Cutrer MF, Yarnitsky D (2001) The development of cutaneous allodynia during a migraine attack clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine. Brain 23:1703–1709
13.
D’Agostino VC, Francia E, Licursi V, Cerbo R (2010) Clinical and personality features of allodynic migraine. Neurol Sci 31(Suppl 1):S159–S161PubMedCrossRef
14.
Burstein R, Jakubowski M (2004) Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization. Ann Neurol 55:27–36PubMedCrossRef
15.
Bigal ME, Lipton RB (2006) Modifiable risk factors for migraine progression. Headache 46:1334–1343PubMedCrossRef
16.
Kurth T, Gaziano JM, Cook NR, Logroscino G, Diener H-C, Buring JE (2006) Migraine and risk of cardiovascular disease in women. J Am Med Assoc 296:283–291CrossRef
17.
Carolei A, Marini C, De Matteis G (1996) History of migraine and risk of cerebral ischaemia in young adults. The Italian national research council study group on stroke in the young. Lancet 347(9014):1503–1506PubMedCrossRef
18.
Schurks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T (2009) Migraine and cardiovascular disease: systematic review and meta-analysis. Br Med J 339:b3914CrossRef
19.
Gillum LA, Mamidipudi SK, Johnston SC (2000) Ischemic stroke risk with oral contraceptives: a meta-analysis. J Am Med Assoc 284:72–78CrossRef
20.
MacClellan LR, Giles W, Cole J, Wozniak M, Stern B, Mitchell BD, Kittner SJ (2007) Probable migraine with visual aura and risk of ischemic stroke: the stroke prevention in young women study. Stroke 38:2438–2445PubMedCrossRef
21.
Kruit MC, van Buchem MA, Launer LJ, Terwindt GM, Ferrari MD (2010) Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: the population-based MRI camera study. Cephalalgia 30:129–136PubMedCentralPubMed
22.
Laurell K, Artto V, Bendtsen L, Hagen K, Kallela M, Meyer EL, Putaala J, Tronvik E, Zwart JA, Linde M (2011) Migrainous infarction: a nordic multicenter study. Eur J Neurol 18:1220–1226PubMedCrossRef
23.
Sacco S, Ornello R, Ripa P, Pistoia F, Carolei A (2013) Migraine and hemorrhagic stroke: a meta-analysis. Stroke 44:3032–3038PubMedCrossRef
24.
Jette N, Patten S, Williams J, Becker W, Wiebe S (2008) Comorbidity of migraine and psychiatric disorders a national population-based study. Headache 48:501–516PubMedCrossRef
25.
Buse DC, Loder EW, Gorman JA, Stewart WF, Reed ML, Fanning KM, Serrano D, Lipton RB (2013) Sex differences in the prevalence, symptoms, and associated features of migraine, probable migraine and other severe headache: results of the American migraine prevalence and prevention (AMPP) study. Headache 53:1278–1299PubMedCrossRef
26.
Scher AI, Stewart WF, Ricci JA, Lipton RB (2003) Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain 106:81–89PubMedCrossRef
27.
Peterlin BL, Rosso AL, Williams MA et al (2013) Episodic migraine and obesity and the influence of age, race, and sex. Neurology 81:1314–1321PubMedCrossRef
28.
Pringsheim T, Gooren L (2004) Migraine prevalence in male to female transsexuals on hormone therapy. Neurology 63:593–594PubMedCrossRef
29.
Bolay H, Berman NEJ, Akcali D (2011) Sex-related differences in animal models of migraine. Headache 51:891–904PubMedCrossRef
30.
Finocchi C, Ferrari M (2011) Female reproductive steroids and neuronal excitability. Neurol Sci 32(Suppl 1):S31–S35PubMedCrossRef
31.
Shyti R, de Vries B, van den Maagdenberg A (2011) Migraine genes and the relation to gender. Headache 51:880–890PubMedCrossRef
32.
Bresolin N, Martinelli P, Barbiroli B et al (1991) Muscle mitochondrial DNA deletion and 31P-NMR spectroscopy alterations in a migraine patient. J Neurol Sci 104:182–189PubMedCrossRef
33.
Nyhoh DR, Curtain RP, Grifiths LR (2000) Familial typical migraine: significant linkage and localization of a gene to Xq24-28. Hum Genet 107:18–23
34.
Wang XP, Liu JM, Zhao YB (2008) Migraine: sex-influenced trait model? Med Hypotheses 71:14–21PubMedCrossRef
35.
Low NC, Cui L, Merikangas KR (2007) Sex differences in the transmission of migraine. Cephalalgia 27:935–942PubMedCrossRef
36.
Rodriguez-Acevedo AJ, Maher BH, Lea RA, Benton M, Griffiths LR (2013) Association of oestrogen-receptor gene (ESR1) polymorphisms with migraine in the large Norfolk Island pedigree. Cephalalgia 33(14):1139–1147PubMedCrossRef
37.
38.
Paulson PE, Minoshima S, Morrow TJ, Casey KL (1998) Gender differences in pain perception and patterns of cerebral activation during noxious heat stimulation in humans. Pain 76:223–229PubMedCentralPubMedCrossRef
39.
Kong J, Loggia ML, Zyloney C, Tu P, Laviolette P, Gollub RL (2010) Exploring the brain in pain: activations, deactivations and their relation. Pain 148:257–267PubMedCentralPubMedCrossRef
40.
Maleki N, Linnman C, Brawn J, Burstein R, Becerra L, Borsook D (2012) Her versus his migraine: multiple sex differences in brain function and structure. Brain 135:2546–2559PubMedCentralPubMedCrossRef
41.
Straube T, Schmidt S, Weiss T, Mentzel HJ, Miltner WH (2009) Sex differences in brain activation to anticipated and experienced pain in the medial prefrontal cortex. Hum Brain Mapp 30:689–698PubMedCrossRef
42.
Liu J, Qin W, Nan J, Li J, Yuan K, Zhao L et al (2011) Gender-related differences in the dysfunctional resting networks of migraine suffers. PLoS One 6:e27049PubMedCentralPubMedCrossRef
43.
Gong G, Rosa-Neto P, Carbonell F, Chen ZJ, He Y et al (2009) Age-and gender-related differences in the cortical anatomical network. J Neurosci 29:15684–15693PubMedCentralPubMedCrossRef
44.
Allais G, Tullo V, Omboni S, Benedetto C, Sances G, Zava D, Ferrari MD, Bussone G (2012) Efficacy of frovatriptan versus other triptans in the acute treatment of menstrual migraine: pooled analysis of three double-blind, randomized, crossover, multicenter studies. Neurol Sci 33(Suppl 1):S65–S69PubMedCrossRef
45.
Silberstein SD, Elkind AH, Schreiber C, Keywood C (2004) A randomized trial of frovatriptan for the intermittent prevention of menstrual migraine. Neurology 63:261–269PubMedCrossRef
46.
Coffee AL, Sulak PJ, Hill AJ, Hansen DJ, Kuehl TJ, Clark JW (2014) Extended cycle combined oral contraceptives and prophylactic frovatriptan during the hormone-free interval in women with menstrual-related migraines. J Women Health 22 Jan 2014[Epub ahead of print]
47.
Maggioni F, Alessi C, Maggino T, Zanchin G (1997) Headache during pregnancy. Cephalalgia 17:765–769PubMedCrossRef
48.
49.
50.
Loder E (2003) Safety of sumatriptan in pregnancy: a review of the data so far. CNS Drugs 17(1):1–7PubMedCrossRef
51.
Olesen C et al (2000) Pregnancy outcome following prescription for sumatriptan. Headache 40(1):20–24PubMedCrossRef
52.
Evers S et al (2006) EFNS guideline on the drug treatment of migraine—report of an EFNS task force. Eur J Neurol 13(6):560–572PubMedCrossRef
53.
Marcus DA, Scharff L, Turk DC (1995) Nonpharmacological management of headaches during pregnancy. Psychosom Med 57(6):527–535PubMedCrossRef
54.
Glasera B, Dimitrakakisc C, Trimblee N, Martinf V (2012) Testosterone pellet implants and migraine headaches: a pilot study. Maturitas 71:385–388CrossRef
55.
Shuster LT, Faubion SS, Sood R, Casey PM (2011) Hormonal manipulation strategies in the management of menstrual migraine and other hormonally related headaches. Curr Neurol Neurosci Rep 11(2):131–138PubMedCrossRef
56.
Almén-Christensson A, Hammar M, Lindh-Åstrand L et al (2011) Prevention of menstrual migraine with perimenstrual transdermal 17-β-estradiol: a randomized, placebo-controlled, double-blind crossover study. Fertil Steril 96:498–500PubMedCrossRef
57.
Nappi RE, Sances G, Detaddei S et al (2009) Hormonal management of migraine at menopause. Menopause Int 15:82–86PubMedCrossRef
58.
Bushnell C, McCullough LD, Awad IA, Chireau MV, Fedder WE, Furie KL, Howard VJ, Lichtman JH, Lisabeth LD, Piña IL, Reeves MJ, Rexrode KR, Saposnik G, Singh V, Towfighi A, Vaccarino V and Walters MR (2014) Guidelines for the prevention of stroke in women: a statement for healthcare professionals from the American heart association/American stroke association. Stroke: (published online 6 February 2014)
59.
Bousser MG, Conard J, Kittner S, de Lignieres B, MacGregor EA, Massiou H, Silberstein SD, Tzourio C (2000) International headache society task force on combined oral contraceptives & hormone replacement therapy. Recommendations on the risk of ischaemic stroke associated with use of combined oral contraceptives and hormone replacement therapy in women with migraine. Cephalalgia 20:155–156PubMedCrossRef
Metadaten
Titel
Sex-related differences in migraine
verfasst von
Cinzia Finocchi
Laura Strada
Publikationsdatum
01.05.2014
Verlag
Springer Milan
Erschienen in
Neurological Sciences / Ausgabe Sonderheft 1/2014
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-014-1772-y

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