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Annals of Surgical Oncology
Erschienen in: Annals of Surgical Oncology 1/2021

19.06.2020 | Hepatobiliary Tumors

Significance of Frailty in Prognosis After Hepatectomy for Elderly Patients with Hepatocellular Carcinoma

verfasst von: Shinichiro Yamada, MD, PhD, FACS, Mitsuo Shimada, MD, PhD, FACS, Yuji Morine, MD, PhD, FACS, Satoru Imura, MD, PhD, FACS, Tetsuya Ikemoto, MD, PhD, FACS, Yusuke Arakawa, MD, PhD, FACS, Yu Saito, MD, PhD, FACS, Masato Yoshikawa, MD, PhD, Katsuki Miyazaki, MD

Erschienen in: Annals of Surgical Oncology | Ausgabe 1/2021

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Abstract

Background

The concept of frailty becomes important for patients who undergo surgery in this recent aging society. The aim of this study is to investigate the frailty as a prognostic factor in elderly patients with hepatocellular carcinoma (HCC) who underwent hepatectomy.

Patients and Methods

A total of 92 patients over 75 years old who underwent hepatectomy were enrolled in this study. Frailty was defined as clinical frailty scale (CFS) ≥ 4. Patients were divided into two groups, i.e., frailty group (n = 21) and no-frailty group (n = 71), and clinicopathological features were compared between them.

Results

The frailty group showed significant higher PIVKA-II level and larger tumor diameter (p < 0.05). CRP level and modified Glasgow prognostic score were significantly higher in the frailty group (p < 0.05). The frailty group showed higher rate of postoperative complications of Clavien–Dindo III (p = 0.06) and longer postoperative stay (p = 0.08). Cancer-specific, overall, and disease-free survival rates were significantly worse in the frailty group (p < 0.05). Frailty was detected as an independent prognostic factor on multivariate analysis of cancer-specific survival.

Conclusion

Frailty can estimate the prognosis of HCC patients who underwent hepatectomy.
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Metadaten
Titel
Significance of Frailty in Prognosis After Hepatectomy for Elderly Patients with Hepatocellular Carcinoma
verfasst von
Shinichiro Yamada, MD, PhD, FACS
Mitsuo Shimada, MD, PhD, FACS
Yuji Morine, MD, PhD, FACS
Satoru Imura, MD, PhD, FACS
Tetsuya Ikemoto, MD, PhD, FACS
Yusuke Arakawa, MD, PhD, FACS
Yu Saito, MD, PhD, FACS
Masato Yoshikawa, MD, PhD
Katsuki Miyazaki, MD
Publikationsdatum
19.06.2020
Verlag
Springer International Publishing
Erschienen in
Annals of Surgical Oncology / Ausgabe 1/2021
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-020-08742-w

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