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Inflammation Research

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27.04.2020 | Original Researh Article

SIKIAT1/miR-96/FOXA1 axis regulates sepsis-induced kidney injury through induction of apoptosis

verfasst von: Shijun Lu, Haibin Wu, Jianhua Xu, Zhaofeng He, Haiyan Li, Chao Ning

Erschienen in: Inflammation Research | Ausgabe 7/2020

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Abstract

Objective and design

Nowadays, sepsis-induced acute kidney injury (AKI) has gradually become a global problem for its high incidence and increasing mortality. Previous study has reported lncRNA ENST00000452391.1 in sepsis patients. However, its potential biological function and downstream molecular mechanism are still mysterious.

Methods and results

Our study found that it was upregulated in sepsis-induced AKI patients, so it was identified as “sepsis-induced kidney injury associated transcript 1 (SIKIAT1)”. We used lipopolysaccharide (LPS) stimulated HK-2 cells as an in vitro model to demonstrated that SIKIAT1 acts as a ceRNA for miR-96-3p to enhance FOXA1 expression and promote HK-2 cell apoptosis.

Conclusion

Therefore, it could be a potential biomarker and therapeutic target for sepsis-induced AKI in the development of disease.

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Titel: SIKIAT1/miR-96/FOXA1 axis regulates sepsis-induced kidney injury through induction of apoptosis
verfasst von: Shijun Lu
Haibin Wu
Jianhua Xu
Zhaofeng He
Haiyan Li
Chao Ning
Publikationsdatum: 27.04.2020
Verlag: Springer International Publishing
Erschienen in: Inflammation Research / Ausgabe 7/2020
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-020-01350-0

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SIKIAT1/miR-96/FOXA1 axis regulates sepsis-induced kidney injury through induction of apoptosis

Abstract

Objective and design

Methods and results

Conclusion

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